Association of human bocavirus 1 infection with respiratory disease in childhood follow-up study, Finland

Mira Meriluoto; Lea Anneli Hedman; Laura Tanner; Ville Simell; Marjaana Mäkinen; Satu Simell; Juha Mykkänen; Jan Korpelainen; Olli Ruuskanen; Jorma Ilonen; Mikael Knip; Olli Simell; Klaus Hedman; Maria Söderlund-Venermo

doi:10.3201/eid1802.111293

Association of human bocavirus 1 infection with respiratory disease in childhood follow-up study, Finland

Mira Meriluoto, Lea Anneli Hedman, Laura Tanner, Ville Simell, Marjaana Mäkinen, Satu Simell, Juha Mykkänen, Jan Korpelainen, Olli Ruuskanen, Jorma Ilonen, Mikael Knip, Olli Simell, Klaus Hedman, Maria Söderlund-Venermo

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

Human bocavirus 1 (HBoV1) DNA is frequently detected
in the upper airways of young children with respiratory
symptoms. Because of its persistence and frequent codetection
with other viruses, however, its etiologic role
has remained controversial. During 2009–2011, using
HBoV1 IgM, IgG, and IgG-avidity enzyme immunoassays
and quantitative PCR, we examined 1,952 serum samples
collected consecutively at 3- to 6-month intervals from
109 constitutionally healthy children from infancy to early
adolescence. Primary HBoV1 infection, as indicated by
seroconversion, appeared in 102 (94%) of 109 children at
a mean age of 2.3 years; the remaining 7 children were
IgG antibody positive from birth. Subsequent secondary
infections or IgG antibody increases were evident in 38
children and IgG reversions in 10. Comparison of the
seroconversion interval with the next sampling interval
for clinical events indicated that HBoV1 primary infection,
but not secondary immune response, was signifi cantly
associated with acute otitis media and respiratory illness.

Original language	English
Journal	Emerging Infectious Diseases
Volume	18
Issue number	2
Pages (from-to)	264-271
Number of pages	8
ISSN	1080-6040
DOIs	https://doi.org/10.3201/eid1802.111293
Publication status	Published - 2012
MoE publication type	A1 Journal article-refereed

Bibliographical note

Erratum: Volume 22, Issue 9, Page 1695. Doi 10.3201/eid2209.C12209

Fields of Science

3111 Biomedicine

Access to Document

10.3201/eid1802.111293

Cite this

Meriluoto, M., Hedman, L. A., Tanner, L., Simell, V., Mäkinen, M., Simell, S., Mykkänen, J., Korpelainen, J., Ruuskanen, O., Ilonen, J., Knip, M., Simell, O., Hedman, K., & Söderlund-Venermo, M. (2012). Association of human bocavirus 1 infection with respiratory disease in childhood follow-up study, Finland. Emerging Infectious Diseases, 18(2), 264-271. https://doi.org/10.3201/eid1802.111293

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title = "Association of human bocavirus 1 infection with respiratory disease in childhood follow-up study, Finland",

abstract = "Human bocavirus 1 (HBoV1) DNA is frequently detectedin the upper airways of young children with respiratorysymptoms. Because of its persistence and frequent codetectionwith other viruses, however, its etiologic rolehas remained controversial. During 2009–2011, usingHBoV1 IgM, IgG, and IgG-avidity enzyme immunoassaysand quantitative PCR, we examined 1,952 serum samplescollected consecutively at 3- to 6-month intervals from109 constitutionally healthy children from infancy to earlyadolescence. Primary HBoV1 infection, as indicated byseroconversion, appeared in 102 (94%) of 109 children ata mean age of 2.3 years; the remaining 7 children wereIgG antibody positive from birth. Subsequent secondaryinfections or IgG antibody increases were evident in 38children and IgG reversions in 10. Comparison of theseroconversion interval with the next sampling intervalfor clinical events indicated that HBoV1 primary infection,but not secondary immune response, was signifi cantlyassociated with acute otitis media and respiratory illness.",

keywords = "3111 Biomedicine",

author = "Mira Meriluoto and Hedman, {Lea Anneli} and Laura Tanner and Ville Simell and Marjaana M{\"a}kinen and Satu Simell and Juha Mykk{\"a}nen and Jan Korpelainen and Olli Ruuskanen and Jorma Ilonen and Mikael Knip and Olli Simell and Klaus Hedman and Maria S{\"o}derlund-Venermo",

note = "Erratum: Volume 22, Issue 9, Page 1695. Doi 10.3201/eid2209.C12209 ",

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Meriluoto, M, Hedman, LA, Tanner, L, Simell, V, Mäkinen, M, Simell, S, Mykkänen, J, Korpelainen, J, Ruuskanen, O, Ilonen, J, Knip, M, Simell, O, Hedman, K & Söderlund-Venermo, M 2012, 'Association of human bocavirus 1 infection with respiratory disease in childhood follow-up study, Finland', Emerging Infectious Diseases, vol. 18, no. 2, pp. 264-271. https://doi.org/10.3201/eid1802.111293

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T1 - Association of human bocavirus 1 infection with respiratory disease in childhood follow-up study, Finland

AU - Meriluoto, Mira

AU - Hedman, Lea Anneli

AU - Tanner, Laura

AU - Simell, Ville

AU - Mäkinen, Marjaana

AU - Simell, Satu

AU - Mykkänen, Juha

AU - Korpelainen, Jan

AU - Ruuskanen, Olli

AU - Ilonen, Jorma

AU - Knip, Mikael

AU - Simell, Olli

AU - Hedman, Klaus

AU - Söderlund-Venermo, Maria

N1 - Erratum: Volume 22, Issue 9, Page 1695. Doi 10.3201/eid2209.C12209

PY - 2012

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N2 - Human bocavirus 1 (HBoV1) DNA is frequently detectedin the upper airways of young children with respiratorysymptoms. Because of its persistence and frequent codetectionwith other viruses, however, its etiologic rolehas remained controversial. During 2009–2011, usingHBoV1 IgM, IgG, and IgG-avidity enzyme immunoassaysand quantitative PCR, we examined 1,952 serum samplescollected consecutively at 3- to 6-month intervals from109 constitutionally healthy children from infancy to earlyadolescence. Primary HBoV1 infection, as indicated byseroconversion, appeared in 102 (94%) of 109 children ata mean age of 2.3 years; the remaining 7 children wereIgG antibody positive from birth. Subsequent secondaryinfections or IgG antibody increases were evident in 38children and IgG reversions in 10. Comparison of theseroconversion interval with the next sampling intervalfor clinical events indicated that HBoV1 primary infection,but not secondary immune response, was signifi cantlyassociated with acute otitis media and respiratory illness.

AB - Human bocavirus 1 (HBoV1) DNA is frequently detectedin the upper airways of young children with respiratorysymptoms. Because of its persistence and frequent codetectionwith other viruses, however, its etiologic rolehas remained controversial. During 2009–2011, usingHBoV1 IgM, IgG, and IgG-avidity enzyme immunoassaysand quantitative PCR, we examined 1,952 serum samplescollected consecutively at 3- to 6-month intervals from109 constitutionally healthy children from infancy to earlyadolescence. Primary HBoV1 infection, as indicated byseroconversion, appeared in 102 (94%) of 109 children ata mean age of 2.3 years; the remaining 7 children wereIgG antibody positive from birth. Subsequent secondaryinfections or IgG antibody increases were evident in 38children and IgG reversions in 10. Comparison of theseroconversion interval with the next sampling intervalfor clinical events indicated that HBoV1 primary infection,but not secondary immune response, was signifi cantlyassociated with acute otitis media and respiratory illness.

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