Association of human bocavirus 1 infection with respiratory disease in childhood follow-up study, Finland

Mira Meriluoto, Lea Anneli Hedman, Laura Tanner, Ville Simell, Marjaana Mäkinen, Satu Simell, Juha Mykkänen, Jan Korpelainen, Olli Ruuskanen, Jorma Ilonen, Mikael Knip, Olli Simell, Klaus Hedman, Maria Söderlund-Venermo

Research output: Contribution to journalArticleScientificpeer-review


Human bocavirus 1 (HBoV1) DNA is frequently detected
in the upper airways of young children with respiratory
symptoms. Because of its persistence and frequent codetection
with other viruses, however, its etiologic role
has remained controversial. During 2009–2011, using
HBoV1 IgM, IgG, and IgG-avidity enzyme immunoassays
and quantitative PCR, we examined 1,952 serum samples
collected consecutively at 3- to 6-month intervals from
109 constitutionally healthy children from infancy to early
adolescence. Primary HBoV1 infection, as indicated by
seroconversion, appeared in 102 (94%) of 109 children at
a mean age of 2.3 years; the remaining 7 children were
IgG antibody positive from birth. Subsequent secondary
infections or IgG antibody increases were evident in 38
children and IgG reversions in 10. Comparison of the
seroconversion interval with the next sampling interval
for clinical events indicated that HBoV1 primary infection,
but not secondary immune response, was signifi cantly
associated with acute otitis media and respiratory illness.
Original languageEnglish
JournalEmerging Infectious Diseases
Issue number2
Pages (from-to)264-271
Number of pages8
Publication statusPublished - 2012
MoE publication typeA1 Journal article-refereed

Bibliographical note

Erratum: Volume 22, Issue 9, Page 1695. Doi 10.3201/eid2209.C12209

Fields of Science

  • 3111 Biomedicine

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