Atypical KRAS(G12R) Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer

G. Aaron Hobbs, Nicole M. Baker, Anne M. Miermont, Ryan D. Thurman, Mariaelena Pierobon, Timothy H. Tran, Andrew O. Anderson, Andrew M. Waters, J. Nathaniel Diehl, Bjoern Papke, Richard G. Hodge, Jennifer E. Klomp, Craig M. Goodwin, Jonathan M. DeLiberty, Junning Wang, Raymond W. S. Ng, Prson Gautam, Kirsten L. Bryant, Dominic Esposito, Sharon L. CampbellEmanuel F. Petricoin, Dhirendra K. Simanshu, Andrew J. Aguirre, Brian M. Wolpin, Krister Wennerberg, Udo Rudloff, Adrienne D. Cox, Channing J. Der

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalCancer Discovery
Volume10
Issue number1
Pages (from-to)104-123
Number of pages20
ISSN2159-8274
DOIs
Publication statusPublished - Jan 2020
MoE publication typeA1 Journal article-refereed

Fields of Science

  • GUANINE-NUCLEOTIDE EXCHANGE
  • ONCOGENIC KRAS
  • RAS-BINDING
  • ACTIVATION
  • PROTEIN
  • TRANSFORMATION
  • KINASE
  • TUMORIGENESIS
  • DEGRADATION
  • P110-ALPHA
  • 3122 Cancers

Cite this

Hobbs, G. A., Baker, N. M., Miermont, A. M., Thurman, R. D., Pierobon, M., Tran, T. H., ... Der, C. J. (2020). Atypical KRAS(G12R) Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer. Cancer Discovery, 10(1), 104-123. https://doi.org/10.1158/2159-8290.CD-19-1006