Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

The Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank Investigators; COVID Human Genetic Effort; CONSTANCES cohort; 3C-Dijon Study; Cerba HealthCare; Etablissement du Sang study group; HGID Lab; COVID Clinicians; COVID-STORM Clinicians; NIAID Immune Response to COVID Group; NH-COVAIR Study Group; Danish CHGE; Danish Blood Donor Study; St. James’s Hospital SARS CoV2 Interest group; French COVID Cohort Study Group; Imagine COVID Group; Paul Bastard; Adrian Gervais; Tom Le Voyer; Mikko R. J. Seppänen

doi:10.1126/sciimmunol.abl4340

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

The Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank Investigators, COVID Human Genetic Effort, CONSTANCES cohort, 3C-Dijon Study, Cerba HealthCare, Etablissement du Sang study group, HGID Lab, COVID Clinicians, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, St. James’s Hospital SARS CoV2 Interest group, French COVID Cohort Study Group, Imagine COVID Group, Paul Bastard, Adrian GervaisTom Le Voyer, Mikko R. J. Seppänen

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	4340
Journal	Science immunology
Volume	6
Issue number	62
Number of pages	26
DOIs	https://doi.org/10.1126/sciimmunol.abl4340
Publication status	Published - 19 Aug 2021
MoE publication type	A1 Journal article-refereed

Bibliographical note

Publisher Copyright:
© 2021 The Authors, some rights reserved.

Fields of Science

3121 General medicine, internal medicine and other clinical medicine
MYASTHENIA-GRAVIS PATIENTS
DISTINCT FUNCTIONS
ANTIBODIES
INTERFERON
ALPHA
AUTOIMMUNITY
ANTINUCLEAR
IMMUNITY
PATIENT

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10.1126/sciimmunol.abl4340

sciimmunol.abl4340Final published version, 4.34 MBLicence: CC BY

Cite this

The Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank Investigators, COVID Human Genetic Effort, CONSTANCES cohort, 3C-Dijon Study, Cerba HealthCare, Etablissement du Sang study group, HGID Lab, COVID Clinicians, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, St. James’s Hospital SARS CoV2 Interest group, French COVID Cohort Study Group, Imagine COVID Group, Bastard, P., ... Seppänen, M. R. J. (2021). Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. Science immunology, 6(62), Article 4340. https://doi.org/10.1126/sciimmunol.abl4340

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title = "Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths",

keywords = "3121 General medicine, internal medicine and other clinical medicine, MYASTHENIA-GRAVIS PATIENTS, DISTINCT FUNCTIONS, ANTIBODIES, INTERFERON, ALPHA, AUTOIMMUNITY, ANTINUCLEAR, IMMUNITY, PATIENT",

author = "{The Milieu Int{\'e}rieur Consortium} and {CoV-Contact Cohort} and {Amsterdam UMC Covid-19 Biobank Investigators} and {COVID Human Genetic Effort} and {CONSTANCES cohort} and {3C-Dijon Study} and {Cerba HealthCare} and {Etablissement du Sang study group} and {HGID Lab} and {COVID Clinicians} and {COVID-STORM Clinicians} and {NIAID Immune Response to COVID Group} and {NH-COVAIR Study Group} and {Danish CHGE} and {Danish Blood Donor Study} and {St. James{\textquoteright}s Hospital SARS CoV2 Interest group} and {French COVID Cohort Study Group} and {Imagine COVID Group} and Paul Bastard and Adrian Gervais and {Le Voyer}, Tom and J{\'e}r{\'e}mie Rosain and Quentin Philippot and J{\'e}r{\'e}my Manry and Eleftherios Michailidis and Hoffmann, {Hans Heinrich} and Shohei Eto and Marina Garcia-Prat and Lucy Bizien and Alba Parra-Mart{\'i}nez and Rui Yang and Liis Haljasm{\"a}gi and M{\'e}lanie Migaud and Karita S{\"a}rekannu and Julia Maslovskaja and Prost, {Nicolas de} and Yacine Tandjaoui-Lambiotte and Luyt, {Charles Edouard} and Blanca Amador-Borrero and Alexandre Gaudet and Julien Poissy and Pascal Morel and Pascale Richard and Fabrice Cognasse and Jesus Troya and Sophie Trouillet-Assant and Alexandre Belot and Kahina Saker and Pierre Gar{\c c}on and Rivi{\`e}re, {Jacques G.} and Lagier, {Jean Christophe} and St{\'e}phanie Gentile and Rosen, {Lindsey B.} and Elana Shaw and Tomohiro Morio and Junko Tanaka and David Dalmau and Tharaux, {Pierre Louis} and Damien Sene and Alain Stepanian and Bruno Megarbane and Vasiliki Triantafyllia and Arnaud Fekkar and Heath, {James R.} and Franco, {Jos{\'e} Luis} and Anaya, {Juan Manuel} and Jordi Sol{\'e}-Viol{\'a}n and Luisa Imberti and Sepp{\"a}nen, {Mikko R. J.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors, some rights reserved.",

year = "2021",

month = aug,

day = "19",

doi = "10.1126/sciimmunol.abl4340",

language = "English",

volume = "6",

journal = "Science immunology",

issn = "2470-9468",

publisher = "American association for the advancement of science",

number = "62",

}

The Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank Investigators, COVID Human Genetic Effort, CONSTANCES cohort, 3C-Dijon Study, Cerba HealthCare, Etablissement du Sang study group, HGID Lab, COVID Clinicians, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, St. James’s Hospital SARS CoV2 Interest group, French COVID Cohort Study Group, Imagine COVID Group, Bastard, P, Gervais, A, Le Voyer, T & Seppänen, MRJ 2021, 'Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths', Science immunology, vol. 6, no. 62, 4340. https://doi.org/10.1126/sciimmunol.abl4340

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. / The Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank Investigators et al.
In: Science immunology, Vol. 6, No. 62, 4340, 19.08.2021.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

AU - The Milieu Intérieur Consortium

AU - CoV-Contact Cohort

AU - Amsterdam UMC Covid-19 Biobank Investigators

AU - COVID Human Genetic Effort

AU - CONSTANCES cohort

AU - 3C-Dijon Study

AU - Cerba HealthCare

AU - Etablissement du Sang study group

AU - HGID Lab

AU - COVID Clinicians

AU - COVID-STORM Clinicians

AU - NIAID Immune Response to COVID Group

AU - NH-COVAIR Study Group

AU - Danish CHGE

AU - Danish Blood Donor Study

AU - St. James’s Hospital SARS CoV2 Interest group

AU - French COVID Cohort Study Group

AU - Imagine COVID Group

AU - Bastard, Paul

AU - Gervais, Adrian

AU - Le Voyer, Tom

AU - Rosain, Jérémie

AU - Philippot, Quentin

AU - Manry, Jérémy

AU - Michailidis, Eleftherios

AU - Hoffmann, Hans Heinrich

AU - Eto, Shohei

AU - Garcia-Prat, Marina

AU - Bizien, Lucy

AU - Parra-Martínez, Alba

AU - Yang, Rui

AU - Haljasmägi, Liis

AU - Migaud, Mélanie

AU - Särekannu, Karita

AU - Maslovskaja, Julia

AU - Prost, Nicolas de

AU - Tandjaoui-Lambiotte, Yacine

AU - Luyt, Charles Edouard

AU - Amador-Borrero, Blanca

AU - Gaudet, Alexandre

AU - Poissy, Julien

AU - Morel, Pascal

AU - Richard, Pascale

AU - Cognasse, Fabrice

AU - Troya, Jesus

AU - Trouillet-Assant, Sophie

AU - Belot, Alexandre

AU - Saker, Kahina

AU - Garçon, Pierre

AU - Rivière, Jacques G.

AU - Lagier, Jean Christophe

AU - Gentile, Stéphanie

AU - Rosen, Lindsey B.

AU - Shaw, Elana

AU - Morio, Tomohiro

AU - Tanaka, Junko

AU - Dalmau, David

AU - Tharaux, Pierre Louis

AU - Sene, Damien

AU - Stepanian, Alain

AU - Megarbane, Bruno

AU - Triantafyllia, Vasiliki

AU - Fekkar, Arnaud

AU - Heath, James R.

AU - Franco, José Luis

AU - Anaya, Juan Manuel

AU - Solé-Violán, Jordi

AU - Imberti, Luisa

AU - Seppänen, Mikko R. J.

PY - 2021/8/19

Y1 - 2021/8/19

KW - 3121 General medicine, internal medicine and other clinical medicine

KW - MYASTHENIA-GRAVIS PATIENTS

KW - DISTINCT FUNCTIONS

KW - ANTIBODIES

KW - INTERFERON

KW - ALPHA

KW - AUTOIMMUNITY

KW - ANTINUCLEAR

KW - IMMUNITY

KW - PATIENT

U2 - 10.1126/sciimmunol.abl4340

DO - 10.1126/sciimmunol.abl4340

M3 - Article

C2 - 34413139

AN - SCOPUS:85113517428

SN - 2470-9468

VL - 6

JO - Science immunology

JF - Science immunology

IS - 62

M1 - 4340

ER -

The Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank Investigators, COVID Human Genetic Effort, CONSTANCES cohort, 3C-Dijon Study et al. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. Science immunology. 2021 Aug 19;6(62):4340. doi: 10.1126/sciimmunol.abl4340