Bevacizumab beyond first diseaase progression in metastatic colorectal cancer: a review of recent clinical trial data

Pia Johanna Österlund, Frank Herrman

Research output: Contribution to journalReview Articlepeer-review


The continuum of care for patients with metastatic colorectal cancer continues to evolve as data from clinical trials evaluating novel agents, treatment combinations or treatment sequencing become available. The concept of continued angiogenesis suppression through multiple lines of therapy has been hypothesized to be beneficial in terms of increased overall survival. This has been evaluated in clinical trials, suggesting that exposure to bevacizumab in the first-line setting and continued beyond first disease progression was associated with statistically significant improvements in survival outcomes. Here, we will discuss the concept of bevacizumab beyond first disease progression in the context of recent clinical trials of bevacizumab, other antiangiogenic agents and other targeted therapies for metastatic colorectal cancer in first- and later-line disease settings.
Original languageEnglish
JournalColorectal cancer
Issue number1
Pages (from-to)13-25
Number of pages13
Publication statusPublished - Jan 2015
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 3122 Cancers

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