Bilateral hemodynamic responses to auditory stimulation in newborn infants

Kalle Kotilahti, Ilkka Nissilä, Minna Huotilainen, Riikka Mäkelä, Nasia Gavrielides, Tommi Noponen, Patrick Björkman, Vineta Fellman, Toivo Katila

Research output: Contribution to journalArticleScientificpeer-review

Abstract

We studied hemodynamic auditory evoked responses of 20 healthy full-term neonates with near-infrared spectroscopy. The instrument used allows the measurements to be performed simultaneously above both auditory cortices. The stimulation consisted of 5-s trains of sound (700-ms interstimulus interval) with a 25-s silent interval. In response to the stimulation, a significant increase in concentration of oxygenated hemoglobin was detected in 14 out of 21 measurements. The mean latency of the largest response was 9.63 +/- 2.20s (mean +/- SD) and the mean amplitude was 1.02 +/- 0.53 mu M. The response amplitude was significantly larger in active (1.28 +/- 0.59 mu M) than in quiet sleep (0.76 +/- 0.32 mu M). The latency of the oxygenated hemoglobin concentration response was significantly shorter (r=-0.70 and p=0.0023) for infants with higher gestational age.
Original languageEnglish
JournalNeuroReport
Volume16
Issue number12
Pages (from-to)1373-1377
Number of pages5
ISSN0959-4965
Publication statusPublished - 2005
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 311 Basic medicine
  • 312 Clinical medicine
  • 318 Medical biotechnology
  • 515 Psychology

Cite this

Kotilahti, K., Nissilä, I., Huotilainen, M., Mäkelä, R., Gavrielides, N., Noponen, T., ... Katila, T. (2005). Bilateral hemodynamic responses to auditory stimulation in newborn infants. NeuroReport, 16(12), 1373-1377.
Kotilahti, Kalle ; Nissilä, Ilkka ; Huotilainen, Minna ; Mäkelä, Riikka ; Gavrielides, Nasia ; Noponen, Tommi ; Björkman, Patrick ; Fellman, Vineta ; Katila, Toivo. / Bilateral hemodynamic responses to auditory stimulation in newborn infants. In: NeuroReport. 2005 ; Vol. 16, No. 12. pp. 1373-1377.
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abstract = "We studied hemodynamic auditory evoked responses of 20 healthy full-term neonates with near-infrared spectroscopy. The instrument used allows the measurements to be performed simultaneously above both auditory cortices. The stimulation consisted of 5-s trains of sound (700-ms interstimulus interval) with a 25-s silent interval. In response to the stimulation, a significant increase in concentration of oxygenated hemoglobin was detected in 14 out of 21 measurements. The mean latency of the largest response was 9.63 +/- 2.20s (mean +/- SD) and the mean amplitude was 1.02 +/- 0.53 mu M. The response amplitude was significantly larger in active (1.28 +/- 0.59 mu M) than in quiet sleep (0.76 +/- 0.32 mu M). The latency of the oxygenated hemoglobin concentration response was significantly shorter (r=-0.70 and p=0.0023) for infants with higher gestational age.",
keywords = "311 Basic medicine, 312 Clinical medicine, 318 Medical biotechnology, 515 Psychology",
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Kotilahti, K, Nissilä, I, Huotilainen, M, Mäkelä, R, Gavrielides, N, Noponen, T, Björkman, P, Fellman, V & Katila, T 2005, 'Bilateral hemodynamic responses to auditory stimulation in newborn infants' NeuroReport, vol. 16, no. 12, pp. 1373-1377.

Bilateral hemodynamic responses to auditory stimulation in newborn infants. / Kotilahti, Kalle; Nissilä, Ilkka; Huotilainen, Minna; Mäkelä, Riikka; Gavrielides, Nasia; Noponen, Tommi; Björkman, Patrick; Fellman, Vineta; Katila, Toivo.

In: NeuroReport, Vol. 16, No. 12, 2005, p. 1373-1377.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Bilateral hemodynamic responses to auditory stimulation in newborn infants

AU - Kotilahti, Kalle

AU - Nissilä, Ilkka

AU - Huotilainen, Minna

AU - Mäkelä, Riikka

AU - Gavrielides, Nasia

AU - Noponen, Tommi

AU - Björkman, Patrick

AU - Fellman, Vineta

AU - Katila, Toivo

PY - 2005

Y1 - 2005

N2 - We studied hemodynamic auditory evoked responses of 20 healthy full-term neonates with near-infrared spectroscopy. The instrument used allows the measurements to be performed simultaneously above both auditory cortices. The stimulation consisted of 5-s trains of sound (700-ms interstimulus interval) with a 25-s silent interval. In response to the stimulation, a significant increase in concentration of oxygenated hemoglobin was detected in 14 out of 21 measurements. The mean latency of the largest response was 9.63 +/- 2.20s (mean +/- SD) and the mean amplitude was 1.02 +/- 0.53 mu M. The response amplitude was significantly larger in active (1.28 +/- 0.59 mu M) than in quiet sleep (0.76 +/- 0.32 mu M). The latency of the oxygenated hemoglobin concentration response was significantly shorter (r=-0.70 and p=0.0023) for infants with higher gestational age.

AB - We studied hemodynamic auditory evoked responses of 20 healthy full-term neonates with near-infrared spectroscopy. The instrument used allows the measurements to be performed simultaneously above both auditory cortices. The stimulation consisted of 5-s trains of sound (700-ms interstimulus interval) with a 25-s silent interval. In response to the stimulation, a significant increase in concentration of oxygenated hemoglobin was detected in 14 out of 21 measurements. The mean latency of the largest response was 9.63 +/- 2.20s (mean +/- SD) and the mean amplitude was 1.02 +/- 0.53 mu M. The response amplitude was significantly larger in active (1.28 +/- 0.59 mu M) than in quiet sleep (0.76 +/- 0.32 mu M). The latency of the oxygenated hemoglobin concentration response was significantly shorter (r=-0.70 and p=0.0023) for infants with higher gestational age.

KW - 311 Basic medicine

KW - 312 Clinical medicine

KW - 318 Medical biotechnology

KW - 515 Psychology

M3 - Article

VL - 16

SP - 1373

EP - 1377

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

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ER -

Kotilahti K, Nissilä I, Huotilainen M, Mäkelä R, Gavrielides N, Noponen T et al. Bilateral hemodynamic responses to auditory stimulation in newborn infants. NeuroReport. 2005;16(12):1373-1377.