Bioactive compounds from medicinal plants: Focus on Piper species

Research output: Contribution to journalReview ArticleScientificpeer-review

Abstract

This article reviews new discoveries related to the phytochemistry and biological activities of bioactive compounds from Piper species. It outlines the anticancer, anti-parasitic, and antimicrobial activities of Piper species in relation to drug discovery. The use of bioactive compounds from medicinal plants as therapeutic agents has been an important area in biomedical and natural product research. Piper species are effective medicinal plants used in folk medicine. They have traditionally been used to treat stomach ache, rheumatoid arthritis, diarrhoea and other general infections, and their efficacy has been attributed to their bioactive compounds. Bioactive compounds and extracts from Piper species have been examined and found to be of clinical importance for both malignant and non-malignant diseases. They have displayed pronounced efficacy as anticancer, antitumour and antimicrobial agents in various pharmacological studies. They have been reported to possess anti-inflammatory, antioxidant, antibacterial, antifungal, and antimalarial activities. The alkaloids piperine, piperlongumine, guineensine, chabamide and pellitorine, which have been isolated from most Piper species, are able to inhibit the growth of cancer cell lines inducing apoptosis and acting as nuclear export inhibitors. These bioactive compounds can improve the effectiveness of chemotherapeutic drugs with minimal systemic toxicity to normal cells in cancer therapy. Pinoresinol, guineensine and other bioactive compounds from this species exhibited strong antimicrobial efficacy against various microorganisms including pathogenic Vibrio strains, which are often involved in host cell invasion during Vibrio cholera infection. The anticancer, antimicrobial and antimalarial properties of Piper species are compiled to support further exploration of their bioactive compounds for drug discovery. Biomedical and pharmacological discoveries concerning their anticancer and antimicrobial properties are highlighted here for further clinical applications, which could pave the way for the proper therapeutic use of bioactive compounds and extracts from this plant species.
Original languageEnglish
JournalSouth African Journal of Botany
Volume112
Pages (from-to)54-69
Number of pages16
ISSN0254-6299
DOIs
Publication statusPublished - 1 Sep 2017
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • 317 Pharmacy

Cite this

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title = "Bioactive compounds from medicinal plants: Focus on Piper species",
abstract = "This article reviews new discoveries related to the phytochemistry and biological activities of bioactive compounds from Piper species. It outlines the anticancer, anti-parasitic, and antimicrobial activities of Piper species in relation to drug discovery. The use of bioactive compounds from medicinal plants as therapeutic agents has been an important area in biomedical and natural product research. Piper species are effective medicinal plants used in folk medicine. They have traditionally been used to treat stomach ache, rheumatoid arthritis, diarrhoea and other general infections, and their efficacy has been attributed to their bioactive compounds. Bioactive compounds and extracts from Piper species have been examined and found to be of clinical importance for both malignant and non-malignant diseases. They have displayed pronounced efficacy as anticancer, antitumour and antimicrobial agents in various pharmacological studies. They have been reported to possess anti-inflammatory, antioxidant, antibacterial, antifungal, and antimalarial activities. The alkaloids piperine, piperlongumine, guineensine, chabamide and pellitorine, which have been isolated from most Piper species, are able to inhibit the growth of cancer cell lines inducing apoptosis and acting as nuclear export inhibitors. These bioactive compounds can improve the effectiveness of chemotherapeutic drugs with minimal systemic toxicity to normal cells in cancer therapy. Pinoresinol, guineensine and other bioactive compounds from this species exhibited strong antimicrobial efficacy against various microorganisms including pathogenic Vibrio strains, which are often involved in host cell invasion during Vibrio cholera infection. The anticancer, antimicrobial and antimalarial properties of Piper species are compiled to support further exploration of their bioactive compounds for drug discovery. Biomedical and pharmacological discoveries concerning their anticancer and antimicrobial properties are highlighted here for further clinical applications, which could pave the way for the proper therapeutic use of bioactive compounds and extracts from this plant species.",
keywords = "317 Pharmacy",
author = "Mgbeahuruike, {Eunice Ego} and Teijo Yrj{\"o}nen and Vuorela, {Heikki Juhani} and Holm, {Yvonne Marianne}",
year = "2017",
month = "9",
day = "1",
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language = "English",
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pages = "54--69",
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Bioactive compounds from medicinal plants : Focus on Piper species. / Mgbeahuruike, Eunice Ego; Yrjönen, Teijo ; Vuorela, Heikki Juhani; Holm, Yvonne Marianne.

In: South African Journal of Botany, Vol. 112, 01.09.2017, p. 54-69.

Research output: Contribution to journalReview ArticleScientificpeer-review

TY - JOUR

T1 - Bioactive compounds from medicinal plants

T2 - Focus on Piper species

AU - Mgbeahuruike, Eunice Ego

AU - Yrjönen, Teijo

AU - Vuorela, Heikki Juhani

AU - Holm, Yvonne Marianne

PY - 2017/9/1

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N2 - This article reviews new discoveries related to the phytochemistry and biological activities of bioactive compounds from Piper species. It outlines the anticancer, anti-parasitic, and antimicrobial activities of Piper species in relation to drug discovery. The use of bioactive compounds from medicinal plants as therapeutic agents has been an important area in biomedical and natural product research. Piper species are effective medicinal plants used in folk medicine. They have traditionally been used to treat stomach ache, rheumatoid arthritis, diarrhoea and other general infections, and their efficacy has been attributed to their bioactive compounds. Bioactive compounds and extracts from Piper species have been examined and found to be of clinical importance for both malignant and non-malignant diseases. They have displayed pronounced efficacy as anticancer, antitumour and antimicrobial agents in various pharmacological studies. They have been reported to possess anti-inflammatory, antioxidant, antibacterial, antifungal, and antimalarial activities. The alkaloids piperine, piperlongumine, guineensine, chabamide and pellitorine, which have been isolated from most Piper species, are able to inhibit the growth of cancer cell lines inducing apoptosis and acting as nuclear export inhibitors. These bioactive compounds can improve the effectiveness of chemotherapeutic drugs with minimal systemic toxicity to normal cells in cancer therapy. Pinoresinol, guineensine and other bioactive compounds from this species exhibited strong antimicrobial efficacy against various microorganisms including pathogenic Vibrio strains, which are often involved in host cell invasion during Vibrio cholera infection. The anticancer, antimicrobial and antimalarial properties of Piper species are compiled to support further exploration of their bioactive compounds for drug discovery. Biomedical and pharmacological discoveries concerning their anticancer and antimicrobial properties are highlighted here for further clinical applications, which could pave the way for the proper therapeutic use of bioactive compounds and extracts from this plant species.

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KW - 317 Pharmacy

U2 - 10.1016/j.sajb.2017.05.007

DO - 10.1016/j.sajb.2017.05.007

M3 - Review Article

VL - 112

SP - 54

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JO - South African Journal of Botany

JF - South African Journal of Botany

SN - 0254-6299

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