Biodegradable Photothermal and pH Responsive Calcium Carbonate@Phospholipid@Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications

Feng Kong, Hongbo Zhang, Xu Zhang, Dongfei Liu, Dong Chen, Weixia Zhang, Liyuan Zhang, Hélder A. Santos, Mingtan Hai

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Biodegradable multifunctional carrier for combination therapy with high efficiency and low side effect is essential for effective cancer treatment and advancing biomedical applications. Therapeutics combination could reduce multidrug resistance and minimize doses through synergism. Here, we develop a biodegradable gold nanodrods@calcium carbonate particles coated with pH-responsive acetalated dextran and phospholipid as advanced platform for incorporation of versatile molecular targeted therapeutics, including hydrophilic and hydrophobic drugs, as well as the model enzyme, green fluorescent protein or antibody. The developed calcium carbonate based hybrid particles show good biocompatibility, stability with photothermal and pH responsiveness, which protected the payloads from premature release, and maintain the enzyme activity. The therapeutics co-loaded CaCO3 based hybrid particles efficiently induces cancer cell death and reduces the multidrug resistance with synergism and has HER2 targeted killing selectivity. The photothermal effects promote ultrafast therapeutics release and induce significant cytotoxicity. Importantly, Anti-HER2 antibody or HER2 targeted therapeutic is more effective on reducing HER2 expression when combined with drug or drugs via synergism. Overall, the cheap and simple manufactured biodegradable hybrid has a great potential for advancing biomedical applications, including targeted photothermal combination therapy by co-delivery of different types of therapeutics, including molecular targeted drugs, antibodies and enzymes.

Original languageEnglish
JournalAdvanced Functional Materials
Volume26
Issue number34
Pages (from-to)6158-6169
Number of pages12
ISSN1616-301X
DOIs
Publication statusPublished - 13 Sep 2016
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 116 Chemical sciences
  • 114 Physical sciences
  • 317 Pharmacy
  • DRUG-DELIVERY
  • POROUS SILICON
  • TRIGGERED RELEASE
  • BREAST-CANCER
  • GOLD NANORODS
  • ORAL DELIVERY
  • NANOPARTICLES
  • ENCAPSULATION
  • FABRICATION
  • DOXORUBICIN

Cite this

@article{ca9fa0ad0f1f42af89fc8fb86a59a5cf,
title = "Biodegradable Photothermal and pH Responsive Calcium Carbonate@Phospholipid@Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications",
abstract = "Biodegradable multifunctional carrier for combination therapy with high efficiency and low side effect is essential for effective cancer treatment and advancing biomedical applications. Therapeutics combination could reduce multidrug resistance and minimize doses through synergism. Here, we develop a biodegradable gold nanodrods@calcium carbonate particles coated with pH-responsive acetalated dextran and phospholipid as advanced platform for incorporation of versatile molecular targeted therapeutics, including hydrophilic and hydrophobic drugs, as well as the model enzyme, green fluorescent protein or antibody. The developed calcium carbonate based hybrid particles show good biocompatibility, stability with photothermal and pH responsiveness, which protected the payloads from premature release, and maintain the enzyme activity. The therapeutics co-loaded CaCO3 based hybrid particles efficiently induces cancer cell death and reduces the multidrug resistance with synergism and has HER2 targeted killing selectivity. The photothermal effects promote ultrafast therapeutics release and induce significant cytotoxicity. Importantly, Anti-HER2 antibody or HER2 targeted therapeutic is more effective on reducing HER2 expression when combined with drug or drugs via synergism. Overall, the cheap and simple manufactured biodegradable hybrid has a great potential for advancing biomedical applications, including targeted photothermal combination therapy by co-delivery of different types of therapeutics, including molecular targeted drugs, antibodies and enzymes.",
keywords = "116 Chemical sciences, 114 Physical sciences, 317 Pharmacy, DRUG-DELIVERY , POROUS SILICON , TRIGGERED RELEASE , BREAST-CANCER , GOLD NANORODS , ORAL DELIVERY , NANOPARTICLES , ENCAPSULATION , FABRICATION , DOXORUBICIN",
author = "Feng Kong and Hongbo Zhang and Xu Zhang and Dongfei Liu and Dong Chen and Weixia Zhang and Liyuan Zhang and Santos, {H{\'e}lder A.} and Mingtan Hai",
year = "2016",
month = "9",
day = "13",
doi = "10.1002/adfm.201602715",
language = "English",
volume = "26",
pages = "6158--6169",
journal = "Advanced Functional Materials",
issn = "1616-301X",
publisher = "Wiley-VCH",
number = "34",

}

Biodegradable Photothermal and pH Responsive Calcium Carbonate@Phospholipid@Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications. / Kong, Feng; Zhang, Hongbo; Zhang, Xu; Liu, Dongfei; Chen, Dong; Zhang, Weixia ; Zhang, Liyuan ; Santos, Hélder A.; Hai, Mingtan.

In: Advanced Functional Materials, Vol. 26, No. 34, 13.09.2016, p. 6158-6169.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Biodegradable Photothermal and pH Responsive Calcium Carbonate@Phospholipid@Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications

AU - Kong, Feng

AU - Zhang, Hongbo

AU - Zhang, Xu

AU - Liu, Dongfei

AU - Chen, Dong

AU - Zhang, Weixia

AU - Zhang, Liyuan

AU - Santos, Hélder A.

AU - Hai, Mingtan

PY - 2016/9/13

Y1 - 2016/9/13

N2 - Biodegradable multifunctional carrier for combination therapy with high efficiency and low side effect is essential for effective cancer treatment and advancing biomedical applications. Therapeutics combination could reduce multidrug resistance and minimize doses through synergism. Here, we develop a biodegradable gold nanodrods@calcium carbonate particles coated with pH-responsive acetalated dextran and phospholipid as advanced platform for incorporation of versatile molecular targeted therapeutics, including hydrophilic and hydrophobic drugs, as well as the model enzyme, green fluorescent protein or antibody. The developed calcium carbonate based hybrid particles show good biocompatibility, stability with photothermal and pH responsiveness, which protected the payloads from premature release, and maintain the enzyme activity. The therapeutics co-loaded CaCO3 based hybrid particles efficiently induces cancer cell death and reduces the multidrug resistance with synergism and has HER2 targeted killing selectivity. The photothermal effects promote ultrafast therapeutics release and induce significant cytotoxicity. Importantly, Anti-HER2 antibody or HER2 targeted therapeutic is more effective on reducing HER2 expression when combined with drug or drugs via synergism. Overall, the cheap and simple manufactured biodegradable hybrid has a great potential for advancing biomedical applications, including targeted photothermal combination therapy by co-delivery of different types of therapeutics, including molecular targeted drugs, antibodies and enzymes.

AB - Biodegradable multifunctional carrier for combination therapy with high efficiency and low side effect is essential for effective cancer treatment and advancing biomedical applications. Therapeutics combination could reduce multidrug resistance and minimize doses through synergism. Here, we develop a biodegradable gold nanodrods@calcium carbonate particles coated with pH-responsive acetalated dextran and phospholipid as advanced platform for incorporation of versatile molecular targeted therapeutics, including hydrophilic and hydrophobic drugs, as well as the model enzyme, green fluorescent protein or antibody. The developed calcium carbonate based hybrid particles show good biocompatibility, stability with photothermal and pH responsiveness, which protected the payloads from premature release, and maintain the enzyme activity. The therapeutics co-loaded CaCO3 based hybrid particles efficiently induces cancer cell death and reduces the multidrug resistance with synergism and has HER2 targeted killing selectivity. The photothermal effects promote ultrafast therapeutics release and induce significant cytotoxicity. Importantly, Anti-HER2 antibody or HER2 targeted therapeutic is more effective on reducing HER2 expression when combined with drug or drugs via synergism. Overall, the cheap and simple manufactured biodegradable hybrid has a great potential for advancing biomedical applications, including targeted photothermal combination therapy by co-delivery of different types of therapeutics, including molecular targeted drugs, antibodies and enzymes.

KW - 116 Chemical sciences

KW - 114 Physical sciences

KW - 317 Pharmacy

KW - DRUG-DELIVERY

KW - POROUS SILICON

KW - TRIGGERED RELEASE

KW - BREAST-CANCER

KW - GOLD NANORODS

KW - ORAL DELIVERY

KW - NANOPARTICLES

KW - ENCAPSULATION

KW - FABRICATION

KW - DOXORUBICIN

UR - http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291616-3028/

U2 - 10.1002/adfm.201602715

DO - 10.1002/adfm.201602715

M3 - Article

VL - 26

SP - 6158

EP - 6169

JO - Advanced Functional Materials

JF - Advanced Functional Materials

SN - 1616-301X

IS - 34

ER -