Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children

Marja Roslund; Riikka Puhakka; Mira Grönroos; Noora Nurminen; Sami Oikarinen; Ahmad M. Gazali; Ondrej Cinek; Lenka Kramna; Nathan Siter; Heli Vari; Laura Soininen; Anirudra Parajuli; Juho Rajaniemi; Tuure Kinnunen; Olli H. Laitinen; Heikki Hyöty; Aki Sinkkonen; The ADELE Research Group

doi:10.1126/sciadv.aba2578

Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children

Marja Roslund, Riikka Puhakka, Mira Grönroos, Noora Nurminen, Sami Oikarinen, Ahmad M. Gazali, Ondrej Cinek, Lenka Kramna, Nathan Siter, Heli Vari, Laura Soininen, Anirudra Parajuli, Juho Rajaniemi, Tuure Kinnunen, Olli H. Laitinen, Heikki Hyöty, Aki Sinkkonen, The ADELE Research Group

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

As the incidence of immune-mediated diseases has increased rapidly in developed societies, there is an unmet need for novel prophylactic practices to fight against these maladies. This study is the first human intervention trial in which urban environmental biodiversity was manipulated to examine its effects on the commensal microbiome and immunoregulation in children. We analyzed changes in the skin and gut microbiota and blood immune markers of children during a 28-day biodiversity intervention. Children in standard urban and nature-oriented daycare centers were analyzed for comparison. The intervention diversified both the environmental and skin Gammaproteobacterial communities, which, in turn, were associated with increases in plasma TGF-beta 1 levels and the proportion of regulatory T cells. The plasma IL-10:IL-17A ratio increased among intervention children during the trial. Our findings suggest that biodiversity intervention enhances immunoregulatory pathways and provide an incentive for future prophylactic approaches to reduce the risk of immune-mediated diseases in urban societies.

Original language	English
Article number	2578
Journal	Science Advances
Volume	6
Issue number	42
Number of pages	10
ISSN	2375-2548
DOIs	https://doi.org/10.1126/sciadv.aba2578
Publication status	Published - 14 Oct 2020
MoE publication type	A1 Journal article-refereed

Fields of Science

3142 Public health care science, environmental and occupational health
INNATE IMMUNITY
HYPOTHESIS
DIVERSITY
DISEASES

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Roslund, M., Puhakka, R., Grönroos, M., Nurminen, N., Oikarinen, S., Gazali, A. M., Cinek, O., Kramna, L., Siter, N., Vari, H., Soininen, L., Parajuli, A., Rajaniemi, J., Kinnunen, T., Laitinen, O. H., Hyöty, H., Sinkkonen, A., & The ADELE Research Group (2020). Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children. Science Advances, 6(42), Article 2578. https://doi.org/10.1126/sciadv.aba2578

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title = "Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children",

abstract = "As the incidence of immune-mediated diseases has increased rapidly in developed societies, there is an unmet need for novel prophylactic practices to fight against these maladies. This study is the first human intervention trial in which urban environmental biodiversity was manipulated to examine its effects on the commensal microbiome and immunoregulation in children. We analyzed changes in the skin and gut microbiota and blood immune markers of children during a 28-day biodiversity intervention. Children in standard urban and nature-oriented daycare centers were analyzed for comparison. The intervention diversified both the environmental and skin Gammaproteobacterial communities, which, in turn, were associated with increases in plasma TGF-beta 1 levels and the proportion of regulatory T cells. The plasma IL-10:IL-17A ratio increased among intervention children during the trial. Our findings suggest that biodiversity intervention enhances immunoregulatory pathways and provide an incentive for future prophylactic approaches to reduce the risk of immune-mediated diseases in urban societies.",

keywords = "3142 Public health care science, environmental and occupational health, INNATE IMMUNITY, HYPOTHESIS, DIVERSITY, DISEASES",

author = "Marja Roslund and Riikka Puhakka and Mira Gr{\"o}nroos and Noora Nurminen and Sami Oikarinen and Gazali, {Ahmad M.} and Ondrej Cinek and Lenka Kramna and Nathan Siter and Heli Vari and Laura Soininen and Anirudra Parajuli and Juho Rajaniemi and Tuure Kinnunen and Laitinen, {Olli H.} and Heikki Hy{\"o}ty and Aki Sinkkonen and {The ADELE Research Group}",

year = "2020",

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Roslund, M , Puhakka, R , Grönroos, M, Nurminen, N, Oikarinen, S, Gazali, AM, Cinek, O, Kramna, L, Siter, N, Vari, H, Soininen, L, Parajuli, A, Rajaniemi, J, Kinnunen, T, Laitinen, OH, Hyöty, H, Sinkkonen, A & The ADELE Research Group 2020, 'Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children', Science Advances, vol. 6, no. 42, 2578. https://doi.org/10.1126/sciadv.aba2578

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T1 - Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children

AU - Roslund, Marja

AU - Puhakka, Riikka

AU - Grönroos, Mira

AU - Nurminen, Noora

AU - Oikarinen, Sami

AU - Gazali, Ahmad M.

AU - Cinek, Ondrej

AU - Kramna, Lenka

AU - Siter, Nathan

AU - Vari, Heli

AU - Soininen, Laura

AU - Parajuli, Anirudra

AU - Rajaniemi, Juho

AU - Kinnunen, Tuure

AU - Laitinen, Olli H.

AU - Hyöty, Heikki

AU - Sinkkonen, Aki

AU - The ADELE Research Group

PY - 2020/10/14

Y1 - 2020/10/14

N2 - As the incidence of immune-mediated diseases has increased rapidly in developed societies, there is an unmet need for novel prophylactic practices to fight against these maladies. This study is the first human intervention trial in which urban environmental biodiversity was manipulated to examine its effects on the commensal microbiome and immunoregulation in children. We analyzed changes in the skin and gut microbiota and blood immune markers of children during a 28-day biodiversity intervention. Children in standard urban and nature-oriented daycare centers were analyzed for comparison. The intervention diversified both the environmental and skin Gammaproteobacterial communities, which, in turn, were associated with increases in plasma TGF-beta 1 levels and the proportion of regulatory T cells. The plasma IL-10:IL-17A ratio increased among intervention children during the trial. Our findings suggest that biodiversity intervention enhances immunoregulatory pathways and provide an incentive for future prophylactic approaches to reduce the risk of immune-mediated diseases in urban societies.

AB - As the incidence of immune-mediated diseases has increased rapidly in developed societies, there is an unmet need for novel prophylactic practices to fight against these maladies. This study is the first human intervention trial in which urban environmental biodiversity was manipulated to examine its effects on the commensal microbiome and immunoregulation in children. We analyzed changes in the skin and gut microbiota and blood immune markers of children during a 28-day biodiversity intervention. Children in standard urban and nature-oriented daycare centers were analyzed for comparison. The intervention diversified both the environmental and skin Gammaproteobacterial communities, which, in turn, were associated with increases in plasma TGF-beta 1 levels and the proportion of regulatory T cells. The plasma IL-10:IL-17A ratio increased among intervention children during the trial. Our findings suggest that biodiversity intervention enhances immunoregulatory pathways and provide an incentive for future prophylactic approaches to reduce the risk of immune-mediated diseases in urban societies.

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KW - INNATE IMMUNITY

KW - HYPOTHESIS

KW - DIVERSITY

KW - DISEASES

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