Bioengineered Porous Silicon Nanoparticles@Macrophages Cell Membrane as Composite Platforms for Rheumatoid Arthritis

Flavia Fontana, Silvia Albertini, Alexandra Correia, Marianna Leena Kemell, Rici Lindgren, Ermei Mäkilä, Jarno Salonen, Jouni Tapio Hirvonen, Franca Ferrari, Helder Almeida Santos

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Biohybrid nanosystems are at the center of personalized medicine, affording prolonged circulation time and targeting to the disease site, and serving as antigenic sources of vaccines. The optimization and functionality parameters of these nanosystems vary depending on the properties of the core particles. In this work, the effects of the core particles’ surface charge and hydrophobicity are evaluated on the nanosystem coating with vesicles derived from plasma membrane. The measured parameters are the dimensions, surface charge, shape, and stability of the biohybrid nanosystems, both in buffer and in biologically relevant media (plasma and simulated synovial fluid). Moreover, the cytocompatibility properties of the developed nanosystems are evaluated in different cell lines mimicking the target cell
populations and other districts of the body involved in the distribution and elimination of the nanoparticles. Finally, the immunological profile of the particles is investigated, highlighting the absence of immune activation promoted by the nanoplatforms.
Original languageEnglish
Article number1801355
JournalAdvanced Functional Materials
Volume28
Issue number22
Number of pages10
ISSN1616-3028
DOIs
Publication statusPublished - 30 May 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 116 Chemical sciences
  • 317 Pharmacy
  • autoimmune diseases
  • cell membrane
  • macrophages
  • nanoparticles
  • porous silicon
  • POLYMERIC NANOPARTICLES
  • ERYTHROCYTE-MEMBRANE
  • DRUG-DELIVERY
  • PARTICLE-SIZE
  • THERAPY
  • BIODISTRIBUTION
  • AUTOIMMUNITY
  • CIRCULATION
  • INSIGHTS
  • ANTIGEN

Cite this

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title = "Bioengineered Porous Silicon Nanoparticles@Macrophages Cell Membrane as Composite Platforms for Rheumatoid Arthritis",
abstract = "Biohybrid nanosystems are at the center of personalized medicine, affording prolonged circulation time and targeting to the disease site, and serving as antigenic sources of vaccines. The optimization and functionality parameters of these nanosystems vary depending on the properties of the core particles. In this work, the effects of the core particles’ surface charge and hydrophobicity are evaluated on the nanosystem coating with vesicles derived from plasma membrane. The measured parameters are the dimensions, surface charge, shape, and stability of the biohybrid nanosystems, both in buffer and in biologically relevant media (plasma and simulated synovial fluid). Moreover, the cytocompatibility properties of the developed nanosystems are evaluated in different cell lines mimicking the target cell populations and other districts of the body involved in the distribution and elimination of the nanoparticles. Finally, the immunological profile of the particles is investigated, highlighting the absence of immune activation promoted by the nanoplatforms.",
keywords = "116 Chemical sciences, 317 Pharmacy, autoimmune diseases, cell membrane, macrophages, nanoparticles, porous silicon, POLYMERIC NANOPARTICLES, ERYTHROCYTE-MEMBRANE, DRUG-DELIVERY, PARTICLE-SIZE, THERAPY, BIODISTRIBUTION, AUTOIMMUNITY, CIRCULATION, INSIGHTS, ANTIGEN",
author = "Flavia Fontana and Silvia Albertini and Alexandra Correia and Kemell, {Marianna Leena} and Rici Lindgren and Ermei M{\"a}kil{\"a} and Jarno Salonen and Hirvonen, {Jouni Tapio} and Franca Ferrari and {Almeida Santos}, Helder",
year = "2018",
month = "5",
day = "30",
doi = "10.1002/adfm.201801355",
language = "English",
volume = "28",
journal = "Advanced Functional Materials",
issn = "1616-301X",
publisher = "Wiley-VCH",
number = "22",

}

Bioengineered Porous Silicon Nanoparticles@Macrophages Cell Membrane as Composite Platforms for Rheumatoid Arthritis. / Fontana, Flavia; Albertini, Silvia; Correia, Alexandra; Kemell, Marianna Leena; Lindgren, Rici; Mäkilä, Ermei; Salonen, Jarno; Hirvonen, Jouni Tapio; Ferrari, Franca; Almeida Santos, Helder.

In: Advanced Functional Materials, Vol. 28, No. 22, 1801355, 30.05.2018.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Bioengineered Porous Silicon Nanoparticles@Macrophages Cell Membrane as Composite Platforms for Rheumatoid Arthritis

AU - Fontana, Flavia

AU - Albertini, Silvia

AU - Correia, Alexandra

AU - Kemell, Marianna Leena

AU - Lindgren, Rici

AU - Mäkilä, Ermei

AU - Salonen, Jarno

AU - Hirvonen, Jouni Tapio

AU - Ferrari, Franca

AU - Almeida Santos, Helder

PY - 2018/5/30

Y1 - 2018/5/30

N2 - Biohybrid nanosystems are at the center of personalized medicine, affording prolonged circulation time and targeting to the disease site, and serving as antigenic sources of vaccines. The optimization and functionality parameters of these nanosystems vary depending on the properties of the core particles. In this work, the effects of the core particles’ surface charge and hydrophobicity are evaluated on the nanosystem coating with vesicles derived from plasma membrane. The measured parameters are the dimensions, surface charge, shape, and stability of the biohybrid nanosystems, both in buffer and in biologically relevant media (plasma and simulated synovial fluid). Moreover, the cytocompatibility properties of the developed nanosystems are evaluated in different cell lines mimicking the target cell populations and other districts of the body involved in the distribution and elimination of the nanoparticles. Finally, the immunological profile of the particles is investigated, highlighting the absence of immune activation promoted by the nanoplatforms.

AB - Biohybrid nanosystems are at the center of personalized medicine, affording prolonged circulation time and targeting to the disease site, and serving as antigenic sources of vaccines. The optimization and functionality parameters of these nanosystems vary depending on the properties of the core particles. In this work, the effects of the core particles’ surface charge and hydrophobicity are evaluated on the nanosystem coating with vesicles derived from plasma membrane. The measured parameters are the dimensions, surface charge, shape, and stability of the biohybrid nanosystems, both in buffer and in biologically relevant media (plasma and simulated synovial fluid). Moreover, the cytocompatibility properties of the developed nanosystems are evaluated in different cell lines mimicking the target cell populations and other districts of the body involved in the distribution and elimination of the nanoparticles. Finally, the immunological profile of the particles is investigated, highlighting the absence of immune activation promoted by the nanoplatforms.

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KW - DRUG-DELIVERY

KW - PARTICLE-SIZE

KW - THERAPY

KW - BIODISTRIBUTION

KW - AUTOIMMUNITY

KW - CIRCULATION

KW - INSIGHTS

KW - ANTIGEN

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