Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47

Linfeng Gao; Maria Barbara Nowakowska; Katja Selby; Adina Przykopanski; Baohua Chen; Maren Krueger; Francois Paul Douillard; Kwok-ho Lam; Peng Chen; Ting Huang; Nigel Peter Minton; Martin Bernhard Dorner; Brigitte Gertrud Dorner; Andreas Rummel; Miia Lindström; Rongsheng Jin

doi:10.1038/s41594-024-01479-0

Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47

Linfeng Gao, Maria Barbara Nowakowska, Katja Selby, Adina Przykopanski, Baohua Chen, Maren Krueger, Francois Paul Douillard, Kwok-ho Lam, Peng Chen, Ting Huang, Nigel Peter Minton, Martin Bernhard Dorner, Brigitte Gertrud Dorner, Andreas Rummel, Miia Lindström, Rongsheng Jin

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Nature Structural and Molecular Biology
Number of pages	36
ISSN	1545-9993
DOIs	https://doi.org/10.1038/s41594-024-01479-0
Publication status	Published - 21 Jan 2025
MoE publication type	A1 Journal article-refereed

Fields of Science

C progenitor toxin
Nonproteolytic clostridium-botulinum
Crystal-structure
Escherichia-coli
Epithelial-cells
Gene clusters
Binding
Hemagglutinin
Reveals
Protein
1182 Biochemistry, cell and molecular biology

Access to Document

10.1038/s41594-024-01479-0

Cite this

Gao, L., Nowakowska, M. B., Selby, K., Przykopanski, A., Chen, B., Krueger, M., Douillard, F. P., Lam, K., Chen, P., Huang, T., Minton, N. P., Dorner, M. B., Dorner, B. G., Rummel, A., Lindström, M., & Jin, R. (2025). Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47. Nature Structural and Molecular Biology. https://doi.org/10.1038/s41594-024-01479-0

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author = "Linfeng Gao and Nowakowska, {Maria Barbara} and Katja Selby and Adina Przykopanski and Baohua Chen and Maren Krueger and Douillard, {Francois Paul} and Kwok-ho Lam and Peng Chen and Ting Huang and Minton, {Nigel Peter} and Dorner, {Martin Bernhard} and Dorner, {Brigitte Gertrud} and Andreas Rummel and Miia Lindstr{\"o}m and Rongsheng Jin",

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doi = "10.1038/s41594-024-01479-0",

language = "English",

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Gao, L, Nowakowska, MB, Selby, K, Przykopanski, A, Chen, B, Krueger, M, Douillard, FP, Lam, K, Chen, P, Huang, T, Minton, NP, Dorner, MB, Dorner, BG, Rummel, A, Lindström, M & Jin, R 2025, 'Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47', Nature Structural and Molecular Biology. https://doi.org/10.1038/s41594-024-01479-0

TY - JOUR

T1 - Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47

AU - Gao, Linfeng

AU - Nowakowska, Maria Barbara

AU - Selby, Katja

AU - Przykopanski, Adina

AU - Chen, Baohua

AU - Krueger, Maren

AU - Douillard, Francois Paul

AU - Lam, Kwok-ho

AU - Chen, Peng

AU - Huang, Ting

AU - Minton, Nigel Peter

AU - Dorner, Martin Bernhard

AU - Dorner, Brigitte Gertrud

AU - Rummel, Andreas

AU - Lindström, Miia

AU - Jin, Rongsheng

PY - 2025/1/21

Y1 - 2025/1/21

KW - C progenitor toxin

KW - Nonproteolytic clostridium-botulinum

KW - Crystal-structure

KW - Escherichia-coli

KW - Epithelial-cells

KW - Gene clusters

KW - Binding

KW - Hemagglutinin

KW - Reveals

KW - Protein

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1038/s41594-024-01479-0

DO - 10.1038/s41594-024-01479-0

M3 - Article

C2 - 39838108

SN - 1545-9993

JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

ER -