BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine

Yuexi Gu, Mikko Helenius, Kristiina Vaananen, Daria Bulanova, Jani Saarela, Anna Sokolenko, John Martens, Evgeny Imyanitov, Sergey Kuznetsov

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
Article number28217
JournalScientific Reports
Volume6
Number of pages9
ISSN2045-2322
DOIs
Publication statusPublished - 17 Jun 2016
MoE publication typeA1 Journal article-refereed

Fields of Science

  • DNA-DAMAGE RESPONSE
  • EMBRYONIC LETHALITY
  • UBIQUITIN LIGASE
  • MISMATCH REPAIR
  • BRCA1
  • MICE
  • IDENTIFICATION
  • TUMORIGENESIS
  • ARRY-142886
  • INSTABILITY
  • 3111 Biomedicine

Cite this

Gu, Yuexi ; Helenius, Mikko ; Vaananen, Kristiina ; Bulanova, Daria ; Saarela, Jani ; Sokolenko, Anna ; Martens, John ; Imyanitov, Evgeny ; Kuznetsov, Sergey. / BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine. In: Scientific Reports. 2016 ; Vol. 6.
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title = "BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine",
keywords = "DNA-DAMAGE RESPONSE, EMBRYONIC LETHALITY, UBIQUITIN LIGASE, MISMATCH REPAIR, BRCA1, MICE, IDENTIFICATION, TUMORIGENESIS, ARRY-142886, INSTABILITY, 3111 Biomedicine",
author = "Yuexi Gu and Mikko Helenius and Kristiina Vaananen and Daria Bulanova and Jani Saarela and Anna Sokolenko and John Martens and Evgeny Imyanitov and Sergey Kuznetsov",
year = "2016",
month = "6",
day = "17",
doi = "10.1038/srep28217",
language = "English",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine. / Gu, Yuexi; Helenius, Mikko; Vaananen, Kristiina; Bulanova, Daria; Saarela, Jani; Sokolenko, Anna; Martens, John; Imyanitov, Evgeny; Kuznetsov, Sergey.

In: Scientific Reports, Vol. 6, 28217, 17.06.2016.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - BRCA1-deficient breast cancer cell lines are resistant to MEK inhibitors and show distinct sensitivities to 6-thioguanine

AU - Gu, Yuexi

AU - Helenius, Mikko

AU - Vaananen, Kristiina

AU - Bulanova, Daria

AU - Saarela, Jani

AU - Sokolenko, Anna

AU - Martens, John

AU - Imyanitov, Evgeny

AU - Kuznetsov, Sergey

PY - 2016/6/17

Y1 - 2016/6/17

KW - DNA-DAMAGE RESPONSE

KW - EMBRYONIC LETHALITY

KW - UBIQUITIN LIGASE

KW - MISMATCH REPAIR

KW - BRCA1

KW - MICE

KW - IDENTIFICATION

KW - TUMORIGENESIS

KW - ARRY-142886

KW - INSTABILITY

KW - 3111 Biomedicine

U2 - 10.1038/srep28217

DO - 10.1038/srep28217

M3 - Article

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 28217

ER -