C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure-activity relationships and biological activities

Virpi Talman; Riccardo Provenzani; Gustav Boije af Gennäs; Raimo K. Tuominen; Jari Yli-Kauhaluoma

doi:10.1042/BST20140181

C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure-activity relationships and biological activities

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Biochemical Society Transactions
Volume	42
Issue number	6
Pages (from-to)	1543-1549
Number of pages	7
ISSN	0300-5127
DOIs	https://doi.org/10.1042/BST20140181
Publication status	Published - Dec 2014
MoE publication type	A1 Journal article-refereed

Fields of Science

Alzheimer's disease
antiproliferative
C1 domain
cancer
isophthalate
neurite growth protein kinase C
CONFORMATIONALLY CONSTRAINED ANALOGS
DIACYLGLYCEROL DAG
PHORBOL ESTER
PKC-ALPHA
NEUROBLASTOMA-CELLS
CATALYTIC DOMAIN
SH-SY5Y CELLS
BINDING
PHOSPHORYLATION
ACTIVATION
317 Pharmacy

Access to Document

10.1042/BST20140181

Talman et al 2014_BiochemSocTrans_C1 domain-targeted isophthalates as protein kinase C modulators_POSTPRINT

Cite this

@article{ad26e48bbbc744fbb99b96e1aaa897f2,

title = "C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure-activity relationships and biological activities",

keywords = "Alzheimer's disease, antiproliferative, C1 domain, cancer, isophthalate, neurite growth protein kinase C, CONFORMATIONALLY CONSTRAINED ANALOGS, DIACYLGLYCEROL DAG, PHORBOL ESTER, PKC-ALPHA, NEUROBLASTOMA-CELLS, CATALYTIC DOMAIN, SH-SY5Y CELLS, BINDING, PHOSPHORYLATION, ACTIVATION, 317 Pharmacy",

author = "Virpi Talman and Riccardo Provenzani and \{af Genn{\"a}s\}, \{Gustav Boije\} and Tuominen, \{Raimo K.\} and Jari Yli-Kauhaluoma",

year = "2014",

month = dec,

doi = "10.1042/BST20140181",

language = "English",

volume = "42",

pages = "1543--1549",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

publisher = "Portland Press Ltd.",

number = "6",

}

C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure-activity relationships and biological activities. / Talman, Virpi ; Provenzani, Riccardo; af Gennäs, Gustav Boije et al.
In: Biochemical Society Transactions, Vol. 42, No. 6, 12.2014, p. 1543-1549.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - C1 domain-targeted isophthalates as protein kinase C modulators

T2 - structure-based design, structure-activity relationships and biological activities

AU - Talman, Virpi

AU - Provenzani, Riccardo

AU - af Gennäs, Gustav Boije

AU - Tuominen, Raimo K.

AU - Yli-Kauhaluoma, Jari

PY - 2014/12

Y1 - 2014/12

KW - Alzheimer's disease

KW - antiproliferative

KW - C1 domain

KW - cancer

KW - isophthalate

KW - neurite growth protein kinase C

KW - CONFORMATIONALLY CONSTRAINED ANALOGS

KW - DIACYLGLYCEROL DAG

KW - PHORBOL ESTER

KW - PKC-ALPHA

KW - NEUROBLASTOMA-CELLS

KW - CATALYTIC DOMAIN

KW - SH-SY5Y CELLS

KW - BINDING

KW - PHOSPHORYLATION

KW - ACTIVATION

KW - 317 Pharmacy

U2 - 10.1042/BST20140181

DO - 10.1042/BST20140181

M3 - Article

SN - 0300-5127

VL - 42

SP - 1543

EP - 1549

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 6

ER -