Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans

E. K. Tarkiainen, M. T. Holmberg, A. Tornio, M. Neuvonen, P. J. Neuvonen, J. T. Backman, M. Niemi

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalClinical Pharmacology and Therapeutics
Volume97
Issue number6
Pages (from-to)650-658
Number of pages9
ISSN0009-9236
DOIs
Publication statusPublished - Jun 2015
MoE publication typeA1 Journal article-refereed

Fields of Science

  • IMPLEMENTATION CONSORTIUM GUIDELINES
  • CARDIOVASCULAR EVENTS
  • MYOCARDIAL-INFARCTION
  • RESPONSE VARIABILITY
  • GENETIC-DETERMINANTS
  • PLATELET INHIBITION
  • CYP2C19 GENOTYPE
  • INCREASED RISK
  • CYP2C19-ASTERISK-17
  • ACTIVATION
  • 317 Pharmacy
  • 3111 Biomedicine

Cite this

@article{af9266f6cb5d4050a3e4bd011950dada,
title = "Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans",
keywords = "IMPLEMENTATION CONSORTIUM GUIDELINES, CARDIOVASCULAR EVENTS, MYOCARDIAL-INFARCTION, RESPONSE VARIABILITY, GENETIC-DETERMINANTS, PLATELET INHIBITION, CYP2C19 GENOTYPE, INCREASED RISK, CYP2C19-ASTERISK-17, ACTIVATION, 317 Pharmacy, 3111 Biomedicine",
author = "Tarkiainen, {E. K.} and Holmberg, {M. T.} and A. Tornio and M. Neuvonen and Neuvonen, {P. J.} and Backman, {J. T.} and M. Niemi",
year = "2015",
month = "6",
doi = "10.1002/cpt.101",
language = "English",
volume = "97",
pages = "650--658",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Wiley",
number = "6",

}

Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans. / Tarkiainen, E. K.; Holmberg, M. T.; Tornio, A.; Neuvonen, M.; Neuvonen, P. J.; Backman, J. T.; Niemi, M.

In: Clinical Pharmacology and Therapeutics, Vol. 97, No. 6, 06.2015, p. 650-658.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans

AU - Tarkiainen, E. K.

AU - Holmberg, M. T.

AU - Tornio, A.

AU - Neuvonen, M.

AU - Neuvonen, P. J.

AU - Backman, J. T.

AU - Niemi, M.

PY - 2015/6

Y1 - 2015/6

KW - IMPLEMENTATION CONSORTIUM GUIDELINES

KW - CARDIOVASCULAR EVENTS

KW - MYOCARDIAL-INFARCTION

KW - RESPONSE VARIABILITY

KW - GENETIC-DETERMINANTS

KW - PLATELET INHIBITION

KW - CYP2C19 GENOTYPE

KW - INCREASED RISK

KW - CYP2C19-ASTERISK-17

KW - ACTIVATION

KW - 317 Pharmacy

KW - 3111 Biomedicine

U2 - 10.1002/cpt.101

DO - 10.1002/cpt.101

M3 - Article

VL - 97

SP - 650

EP - 658

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 6

ER -