Cellular sterol trafficking and metabolism: spotlight on structure

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Cholesterol is the main but not the only sterol in cell membranes of higher eukaryotes. Currently, there is an increasing interest toward structurally different sterols, because their membrane partitioning, trafficking, and metabolic properties may differ considerably from those of cholesterol. There is also growing information on specific sterol-protein interactions and their functional consequences, as exemplified by NPC proteins and select ABC-transporters. Several aspects of sterol trafficking and homeostasis are conserved between eukaryotes, and novel, unanticipated findings in this area have recently been made, particularly from genetic screens in yeast. This includes a novel, reversible modification of the sterol structure that affects the choice of transport route.
Original languageEnglish
JournalCurrent Opinion in Cell Biology
Volume20
Pages (from-to)371-377
Number of pages7
ISSN0955-0674
DOIs
Publication statusPublished - 2008
MoE publication typeA1 Journal article-refereed

Cite this

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title = "Cellular sterol trafficking and metabolism: spotlight on structure",
abstract = "Cholesterol is the main but not the only sterol in cell membranes of higher eukaryotes. Currently, there is an increasing interest toward structurally different sterols, because their membrane partitioning, trafficking, and metabolic properties may differ considerably from those of cholesterol. There is also growing information on specific sterol-protein interactions and their functional consequences, as exemplified by NPC proteins and select ABC-transporters. Several aspects of sterol trafficking and homeostasis are conserved between eukaryotes, and novel, unanticipated findings in this area have recently been made, particularly from genetic screens in yeast. This includes a novel, reversible modification of the sterol structure that affects the choice of transport route.",
author = "Elina Ikonen and Maurice Jansen",
year = "2008",
doi = "10.1016/j.ceb.2008.03.017",
language = "English",
volume = "20",
pages = "371--377",
journal = "Current Opinion in Cell Biology",
issn = "0955-0674",
publisher = "Current Biology",

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Cellular sterol trafficking and metabolism : spotlight on structure. / Ikonen, Elina; Jansen, Maurice.

In: Current Opinion in Cell Biology, Vol. 20, 2008, p. 371-377.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Cellular sterol trafficking and metabolism

T2 - spotlight on structure

AU - Ikonen, Elina

AU - Jansen, Maurice

PY - 2008

Y1 - 2008

N2 - Cholesterol is the main but not the only sterol in cell membranes of higher eukaryotes. Currently, there is an increasing interest toward structurally different sterols, because their membrane partitioning, trafficking, and metabolic properties may differ considerably from those of cholesterol. There is also growing information on specific sterol-protein interactions and their functional consequences, as exemplified by NPC proteins and select ABC-transporters. Several aspects of sterol trafficking and homeostasis are conserved between eukaryotes, and novel, unanticipated findings in this area have recently been made, particularly from genetic screens in yeast. This includes a novel, reversible modification of the sterol structure that affects the choice of transport route.

AB - Cholesterol is the main but not the only sterol in cell membranes of higher eukaryotes. Currently, there is an increasing interest toward structurally different sterols, because their membrane partitioning, trafficking, and metabolic properties may differ considerably from those of cholesterol. There is also growing information on specific sterol-protein interactions and their functional consequences, as exemplified by NPC proteins and select ABC-transporters. Several aspects of sterol trafficking and homeostasis are conserved between eukaryotes, and novel, unanticipated findings in this area have recently been made, particularly from genetic screens in yeast. This includes a novel, reversible modification of the sterol structure that affects the choice of transport route.

U2 - 10.1016/j.ceb.2008.03.017

DO - 10.1016/j.ceb.2008.03.017

M3 - Article

VL - 20

SP - 371

EP - 377

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

ER -