Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo

Katrina Albert; Diana P. Raymundo; Anne Panhelainen; Ave Eesmaa; Liana Shvachiy; Gabriela R. Araujo; Piotr Chmielarz; Xu Yan; Aastha Singh; Yraima Cordeiro; Fernando L. Palhano; Debora Foguel; Kelvin C. Luk; Andrii Domanskyi; Merja H. Voutilainen; Henri J. Huttunen; Tiago F. Outeiro; Mart Saarma; Marcius S.  Almeida; Mikko Airavaara

doi:10.1016/j.ymthe.2021.04.035

Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo

Katrina Albert, Diana P. Raymundo, Anne Panhelainen, Ave Eesmaa, Liana Shvachiy, Gabriela R. Araujo, Piotr Chmielarz, Xu Yan, Aastha Singh, Yraima Cordeiro, Fernando L. Palhano, Debora Foguel, Kelvin C. Luk, Andrii Domanskyi, Merja H. Voutilainen, Henri J. Huttunen, Tiago F. Outeiro, Mart Saarma, Marcius S. Almeida, Mikko Airavaara

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Molecular therapy
Volume	29
Issue number	9
Pages (from-to)	2821-2840
Number of pages	20
ISSN	1525-0016
DOIs	https://doi.org/10.1016/j.ymthe.2021.04.035
Publication status	Published - 1 Sept 2021
MoE publication type	A1 Journal article-refereed

Fields of Science

UNFOLDED PROTEIN RESPONSE
TO-NEURON TRANSMISSION
LEWY BODY
PARKINSONS-DISEASE
BRAIN PATHOLOGY
FACTOR CDNF
FIBRILS
OLIGOMERS
SECRETION
TOXICITY
3112 Neurosciences
317 Pharmacy

Access to Document

10.1016/j.ymthe.2021.04.035

1-s2.0-S1525001621002495-mainFinal published version, 3.23 MBLicence: CC BY

Cite this

Albert, K., Raymundo, D. P., Panhelainen, A., Eesmaa, A., Shvachiy, L., Araujo, G. R., Chmielarz, P., Yan, X., Singh, A., Cordeiro, Y., Palhano, F. L., Foguel, D., Luk, K. C., Domanskyi, A., Voutilainen, M. H., Huttunen, H. J., Outeiro, T. F., Saarma, M., Almeida, M. S., & Airavaara, M. (2021). Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo. Molecular therapy, 29(9), 2821-2840. https://doi.org/10.1016/j.ymthe.2021.04.035

@article{b51a571d5d7e4943a90a8332a77e0e91,

title = "Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo",

keywords = "UNFOLDED PROTEIN RESPONSE, TO-NEURON TRANSMISSION, LEWY BODY, PARKINSONS-DISEASE, BRAIN PATHOLOGY, FACTOR CDNF, FIBRILS, OLIGOMERS, SECRETION, TOXICITY, 3112 Neurosciences, 317 Pharmacy",

author = "Katrina Albert and Raymundo, {Diana P.} and Anne Panhelainen and Ave Eesmaa and Liana Shvachiy and Araujo, {Gabriela R.} and Piotr Chmielarz and Xu Yan and Aastha Singh and Yraima Cordeiro and Palhano, {Fernando L.} and Debora Foguel and Luk, {Kelvin C.} and Andrii Domanskyi and Voutilainen, {Merja H.} and Huttunen, {Henri J.} and Outeiro, {Tiago F.} and Mart Saarma and Almeida, {Marcius S.} and Mikko Airavaara",

year = "2021",

month = sep,

day = "1",

doi = "10.1016/j.ymthe.2021.04.035",

language = "English",

volume = "29",

pages = "2821--2840",

journal = "Molecular therapy",

issn = "1525-0016",

publisher = "Cell Press",

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Albert, K, Raymundo, DP, Panhelainen, A, Eesmaa, A, Shvachiy, L, Araujo, GR, Chmielarz, P, Yan, X, Singh, A, Cordeiro, Y, Palhano, FL, Foguel, D, Luk, KC, Domanskyi, A , Voutilainen, MH, Huttunen, HJ, Outeiro, TF, Saarma, M, Almeida, MS & Airavaara, M 2021, 'Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo', Molecular therapy, vol. 29, no. 9, pp. 2821-2840. https://doi.org/10.1016/j.ymthe.2021.04.035

TY - JOUR

T1 - Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo

AU - Albert, Katrina

AU - Raymundo, Diana P.

AU - Panhelainen, Anne

AU - Eesmaa, Ave

AU - Shvachiy, Liana

AU - Araujo, Gabriela R.

AU - Chmielarz, Piotr

AU - Yan, Xu

AU - Singh, Aastha

AU - Cordeiro, Yraima

AU - Palhano, Fernando L.

AU - Foguel, Debora

AU - Luk, Kelvin C.

AU - Domanskyi, Andrii

AU - Voutilainen, Merja H.

AU - Huttunen, Henri J.

AU - Outeiro, Tiago F.

AU - Saarma, Mart

AU - Almeida, Marcius S.

AU - Airavaara, Mikko

PY - 2021/9/1

Y1 - 2021/9/1

KW - UNFOLDED PROTEIN RESPONSE

KW - TO-NEURON TRANSMISSION

KW - LEWY BODY

KW - PARKINSONS-DISEASE

KW - BRAIN PATHOLOGY

KW - FACTOR CDNF

KW - FIBRILS

KW - OLIGOMERS

KW - SECRETION

KW - TOXICITY

KW - 3112 Neurosciences

KW - 317 Pharmacy

U2 - 10.1016/j.ymthe.2021.04.035

DO - 10.1016/j.ymthe.2021.04.035

M3 - Article

SN - 1525-0016

VL - 29

SP - 2821

EP - 2840

JO - Molecular therapy

JF - Molecular therapy

IS - 9

ER -