Challenges of Using In Vitro Data for Modeling P-Glycoprotein Efflux in the Blood-Brain Barrier

Noora Sjöstedt; Hanna-Sisko Kortejärvi; Heidi Kidron; Kati-Sisko Vellonen; Arto Urtti; Marjo Yliperttula

doi:10.1007/s11095-013-1124-2

Challenges of Using In Vitro Data for Modeling P-Glycoprotein Efflux in the Blood-Brain Barrier

Noora Sjöstedt, Hanna-Sisko Kortejärvi, Heidi Kidron, Kati-Sisko Vellonen, Arto Urtti, Marjo Yliperttula

Research output: Contribution to journal › Review Article › peer-review

Original language	English
Journal	Pharmaceutical Research
Volume	31
Issue number	1
Pages (from-to)	1-19
Number of pages	19
ISSN	0724-8741
DOIs	https://doi.org/10.1007/s11095-013-1124-2
Publication status	Published - 2014
MoE publication type	A2 Review article in a scientific journal

Fields of Science

blood-brain barrier
efflux transport
in vitro-in vivo extrapolation
p-glycoprotein
physiologically based pharmacokinetic modeling
CENTRAL-NERVOUS-SYSTEM
PHYSIOLOGICALLY-BASED PHARMACOKINETICS
TARGETED ABSOLUTE PROTEOMICS
CARRIER-MEDIATED PROCESSES
CACO-2 CELL MONOLAYERS
PLASMA-PROTEIN BINDING
DRUG TRANSPORT
ATPASE ACTIVITY
ENDOTHELIAL-CELLS
TISSUE BINDING
317 Pharmacy

Access to Document

10.1007/s11095-013-1124-2

Cite this

@article{25e7819668b84693badd77ce31a3f383,

title = "Challenges of Using In Vitro Data for Modeling P-Glycoprotein Efflux in the Blood-Brain Barrier",

keywords = "blood-brain barrier, efflux transport, in vitro-in vivo extrapolation, p-glycoprotein, physiologically based pharmacokinetic modeling, CENTRAL-NERVOUS-SYSTEM, PHYSIOLOGICALLY-BASED PHARMACOKINETICS, TARGETED ABSOLUTE PROTEOMICS, CARRIER-MEDIATED PROCESSES, CACO-2 CELL MONOLAYERS, PLASMA-PROTEIN BINDING, DRUG TRANSPORT, ATPASE ACTIVITY, ENDOTHELIAL-CELLS, TISSUE BINDING, 317 Pharmacy",

author = "Noora Sj{\"o}stedt and Hanna-Sisko Kortej{\"a}rvi and Heidi Kidron and Kati-Sisko Vellonen and Arto Urtti and Marjo Yliperttula",

year = "2014",

doi = "10.1007/s11095-013-1124-2",

language = "English",

volume = "31",

pages = "1--19",

journal = "Pharmaceutical Research",

issn = "0724-8741",

publisher = "SPRINGER/PLENUM PUBLISHERS",

number = "1",

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TY - JOUR

T1 - Challenges of Using In Vitro Data for Modeling P-Glycoprotein Efflux in the Blood-Brain Barrier

AU - Sjöstedt, Noora

AU - Kortejärvi, Hanna-Sisko

AU - Kidron, Heidi

AU - Vellonen, Kati-Sisko

AU - Urtti, Arto

AU - Yliperttula, Marjo

PY - 2014

Y1 - 2014

KW - blood-brain barrier

KW - efflux transport

KW - in vitro-in vivo extrapolation

KW - p-glycoprotein

KW - physiologically based pharmacokinetic modeling

KW - CENTRAL-NERVOUS-SYSTEM

KW - PHYSIOLOGICALLY-BASED PHARMACOKINETICS

KW - TARGETED ABSOLUTE PROTEOMICS

KW - CARRIER-MEDIATED PROCESSES

KW - CACO-2 CELL MONOLAYERS

KW - PLASMA-PROTEIN BINDING

KW - DRUG TRANSPORT

KW - ATPASE ACTIVITY

KW - ENDOTHELIAL-CELLS

KW - TISSUE BINDING

KW - 317 Pharmacy

U2 - 10.1007/s11095-013-1124-2

DO - 10.1007/s11095-013-1124-2

M3 - Review Article

VL - 31

SP - 1

EP - 19

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 1

ER -