Chapter 16: Biofunctionalized mesoporous silica nanomaterials for targeted drug delivery (Book Chapter)

Antti Rahikkala, Jessica M. Rosenholm, Helder Almeida Santos

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Abstract

Pharmaceutical nanocarriers are rapidly developing toward “magic bullets” with highly specified target cells and tissues, as well as controlled release of therapeutic agents. However, several challenges remain unanswered, such as the premature release of the drugs, the adverse side effects, and the toxic degradation products or nanoparticle accumulation in the organs. As one of the most interesting nanoplatforms, mesoporous silica nanoparticles (MSNs) feature as promising drug delivery platforms with a great capability to highly specialized functionalization and tunability. The diameter and shape of the particles, in tandem with the size and connectivity of the mesopores, can be controlled in a precise fashion during the fabrication process. The surface chemistry can also be tuned to allow for conjugation of functional molecules, such as prodrugs, targeting molecules, or responsive polymers for controlled drug release, as well as for controlling the surface charge according to the requirements of the application. High surface area allows loading diverse amounts of drugs, while the expandable pore size facilitates also the loading of larger therapeutic agents, such as proteins and DNA. Furthermore, silica biodegrades into silicic acid, which is nontoxic and is rapidly excreted via the urinary pathway. MSNs have been demonstrated to have potential applications as multifunctional delivery platforms with targeted delivery, controlled release, and theranostics, a few of which will be highlighted in this review.
Original languageEnglish
Title of host publicationBiomedical Applications of Functionalized Nanomaterials : Concepts, Development and Clinical Translation
EditorsBruno Sarmento, José das Neves
Number of pages32
Place of PublicationSaint Louis
PublisherElsevier Scientific Publ. Co
Publication date15 Mar 2018
Pages489–520
ISBN (Print) 978-0-323-50878-0
DOIs
Publication statusPublished - 15 Mar 2018
MoE publication typeA3 Book chapter

Publication series

NameMicro and Nano Technologies

Fields of Science

  • 317 Pharmacy
  • 216 Materials engineering
  • 221 Nano-technology

Cite this

Rahikkala, A., Rosenholm, J. M., & Almeida Santos, H. (2018). Chapter 16: Biofunctionalized mesoporous silica nanomaterials for targeted drug delivery (Book Chapter). In B. Sarmento, & J. das Neves (Eds.), Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation (pp. 489–520). (Micro and Nano Technologies). Saint Louis: Elsevier Scientific Publ. Co. https://doi.org/10.1016/B978-0-323-50878-0.00016-1
Rahikkala, Antti ; Rosenholm, Jessica M. ; Almeida Santos, Helder. / Chapter 16: Biofunctionalized mesoporous silica nanomaterials for targeted drug delivery (Book Chapter). Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation. editor / Bruno Sarmento ; José das Neves. Saint Louis : Elsevier Scientific Publ. Co, 2018. pp. 489–520 (Micro and Nano Technologies).
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Rahikkala, A, Rosenholm, JM & Almeida Santos, H 2018, Chapter 16: Biofunctionalized mesoporous silica nanomaterials for targeted drug delivery (Book Chapter). in B Sarmento & J das Neves (eds), Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation. Micro and Nano Technologies, Elsevier Scientific Publ. Co, Saint Louis, pp. 489–520. https://doi.org/10.1016/B978-0-323-50878-0.00016-1

Chapter 16: Biofunctionalized mesoporous silica nanomaterials for targeted drug delivery (Book Chapter). / Rahikkala, Antti ; Rosenholm, Jessica M.; Almeida Santos, Helder.

Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation. ed. / Bruno Sarmento; José das Neves. Saint Louis : Elsevier Scientific Publ. Co, 2018. p. 489–520 (Micro and Nano Technologies).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

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AB - Pharmaceutical nanocarriers are rapidly developing toward “magic bullets” with highly specified target cells and tissues, as well as controlled release of therapeutic agents. However, several challenges remain unanswered, such as the premature release of the drugs, the adverse side effects, and the toxic degradation products or nanoparticle accumulation in the organs. As one of the most interesting nanoplatforms, mesoporous silica nanoparticles (MSNs) feature as promising drug delivery platforms with a great capability to highly specialized functionalization and tunability. The diameter and shape of the particles, in tandem with the size and connectivity of the mesopores, can be controlled in a precise fashion during the fabrication process. The surface chemistry can also be tuned to allow for conjugation of functional molecules, such as prodrugs, targeting molecules, or responsive polymers for controlled drug release, as well as for controlling the surface charge according to the requirements of the application. High surface area allows loading diverse amounts of drugs, while the expandable pore size facilitates also the loading of larger therapeutic agents, such as proteins and DNA. Furthermore, silica biodegrades into silicic acid, which is nontoxic and is rapidly excreted via the urinary pathway. MSNs have been demonstrated to have potential applications as multifunctional delivery platforms with targeted delivery, controlled release, and theranostics, a few of which will be highlighted in this review.

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BT - Biomedical Applications of Functionalized Nanomaterials

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CY - Saint Louis

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Rahikkala A, Rosenholm JM, Almeida Santos H. Chapter 16: Biofunctionalized mesoporous silica nanomaterials for targeted drug delivery (Book Chapter). In Sarmento B, das Neves J, editors, Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation. Saint Louis: Elsevier Scientific Publ. Co. 2018. p. 489–520. (Micro and Nano Technologies). https://doi.org/10.1016/B978-0-323-50878-0.00016-1