Characterization of Expanded Gamma Delta T Cells from Atypical X-SCID Patient Reveals Preserved Function and IL2RG-Mediated Signaling

Elina A. Tuovinen; Sakari Pöysti; Firas Hamdan; Kim My Le; Salla Keskitalo; Tanja Turunen; Lea Minier; Nanni Mamia; Kaarina Heiskanen; Markku Varjosalo; Vincenzo Cerullo; Juha Kere; Mikko R. J. Seppänen; Arno Hänninen; Juha Grönholm

doi:10.1007/s10875-022-01375-6

Characterization of Expanded Gamma Delta T Cells from Atypical X-SCID Patient Reveals Preserved Function and IL2RG-Mediated Signaling

Elina A. Tuovinen, Sakari Pöysti, Firas Hamdan, Kim My Le, Salla Keskitalo, Tanja Turunen, Lea Minier, Nanni Mamia, Kaarina Heiskanen, Markku Varjosalo, Vincenzo Cerullo, Juha Kere, Mikko R. J. Seppänen, Arno Hänninen, Juha Grönholm

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Journal of Clinical Immunology
Volume	43
Issue number	2
Pages (from-to)	358–370
Number of pages	13
ISSN	0271-9142
DOIs	https://doi.org/10.1007/s10875-022-01375-6
Publication status	Published - Feb 2023
MoE publication type	A1 Journal article-refereed

Fields of Science

X-linked combined immunodeficiency
Severe combined immunodeficiency, atypical
Interleukin receptor common subunit gamma
IL2RG
Gamma-delta T-cell receptor
SEVERE COMBINED IMMUNODEFICIENCY
COMBINED IMMUNE-DEFICIENCY
MISSENSE MUTATION
CHAIN
LYMPHOCYTES
ACTIVATION
ANTIGEN
1182 Biochemistry, cell and molecular biology

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Cite this

Tuovinen, E. A., Pöysti, S., Hamdan, F., Le, K. M., Keskitalo, S., Turunen, T., Minier, L., Mamia, N., Heiskanen, K., Varjosalo, M., Cerullo, V., Kere, J., Seppänen, M. R. J., Hänninen, A., & Grönholm, J. (2023). Characterization of Expanded Gamma Delta T Cells from Atypical X-SCID Patient Reveals Preserved Function and IL2RG-Mediated Signaling. Journal of Clinical Immunology, 43(2), 358–370. https://doi.org/10.1007/s10875-022-01375-6

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title = "Characterization of Expanded Gamma Delta T Cells from Atypical X-SCID Patient Reveals Preserved Function and IL2RG-Mediated Signaling",

keywords = "X-linked combined immunodeficiency, Severe combined immunodeficiency, atypical, Interleukin receptor common subunit gamma, IL2RG, Gamma-delta T-cell receptor, SEVERE COMBINED IMMUNODEFICIENCY, COMBINED IMMUNE-DEFICIENCY, MISSENSE MUTATION, CHAIN, LYMPHOCYTES, ACTIVATION, ANTIGEN, 1182 Biochemistry, cell and molecular biology",

author = "Tuovinen, {Elina A.} and Sakari P{\"o}ysti and Firas Hamdan and Le, {Kim My} and Salla Keskitalo and Tanja Turunen and Lea Minier and Nanni Mamia and Kaarina Heiskanen and Markku Varjosalo and Vincenzo Cerullo and Juha Kere and Sepp{\"a}nen, {Mikko R. J.} and Arno H{\"a}nninen and Juha Gr{\"o}nholm",

year = "2023",

month = feb,

doi = "10.1007/s10875-022-01375-6",

language = "English",

volume = "43",

pages = "358–370",

journal = "Journal of Clinical Immunology",

issn = "0271-9142",

publisher = "Springer",

number = "2",

}

Tuovinen, EA, Pöysti, S, Hamdan, F , Le, KM , Keskitalo, S, Turunen, T, Minier, L, Mamia, N, Heiskanen, K, Varjosalo, M , Cerullo, V , Kere, J , Seppänen, MRJ, Hänninen, A & Grönholm, J 2023, 'Characterization of Expanded Gamma Delta T Cells from Atypical X-SCID Patient Reveals Preserved Function and IL2RG-Mediated Signaling', Journal of Clinical Immunology, vol. 43, no. 2, pp. 358–370. https://doi.org/10.1007/s10875-022-01375-6

TY - JOUR

T1 - Characterization of Expanded Gamma Delta T Cells from Atypical X-SCID Patient Reveals Preserved Function and IL2RG-Mediated Signaling

AU - Tuovinen, Elina A.

AU - Pöysti, Sakari

AU - Hamdan, Firas

AU - Le, Kim My

AU - Keskitalo, Salla

AU - Turunen, Tanja

AU - Minier, Lea

AU - Mamia, Nanni

AU - Heiskanen, Kaarina

AU - Varjosalo, Markku

AU - Cerullo, Vincenzo

AU - Kere, Juha

AU - Seppänen, Mikko R. J.

AU - Hänninen, Arno

AU - Grönholm, Juha

PY - 2023/2

Y1 - 2023/2

KW - X-linked combined immunodeficiency

KW - Severe combined immunodeficiency, atypical

KW - Interleukin receptor common subunit gamma

KW - IL2RG

KW - Gamma-delta T-cell receptor

KW - SEVERE COMBINED IMMUNODEFICIENCY

KW - COMBINED IMMUNE-DEFICIENCY

KW - MISSENSE MUTATION

KW - CHAIN

KW - LYMPHOCYTES

KW - ACTIVATION

KW - ANTIGEN

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1007/s10875-022-01375-6

DO - 10.1007/s10875-022-01375-6

M3 - Article

SN - 0271-9142

VL - 43

SP - 358

EP - 370

JO - Journal of Clinical Immunology

JF - Journal of Clinical Immunology

IS - 2

ER -