Characterization of Solid-State Complexities in Pharmaceutical Materials via Stimulated Raman Scattering Microscopy

Elina A. Harju; Teemu Tomberg; Lea Wurr; Anneleen van Rijckeghem; Alba M. Arbiol Enguita; Vladimir Dordovic; Niklas G. Johansson; Heikki Räikkönen; Antti Isomäki; Jukka K. S. Saarinen; Keith C. Gordon; Bert van Veen; Clare J. Strachan

doi:10.1021/acs.analchem.4c03163

Characterization of Solid-State Complexities in Pharmaceutical Materials via Stimulated Raman Scattering Microscopy

Elina A. Harju, Teemu Tomberg, Lea Wurr, Anneleen van Rijckeghem, Alba M. Arbiol Enguita, Vladimir Dordovic, Niklas G. Johansson, Heikki Räikkönen, Antti Isomäki, Jukka K. S. Saarinen, Keith C. Gordon, Bert van Veen, Clare J. Strachan

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Analytical Chemistry
Pages (from-to)	9627-9637
Number of pages	11
ISSN	0003-2700
DOIs	https://doi.org/10.1021/acs.analchem.4c03163
Publication status	Published - 30 Apr 2025
MoE publication type	A1 Journal article-refereed

Fields of Science

Alpha-lactose monohydrate
X-ray-diffraction
Spectroscopy
Spray
Crystallization
Crystallinity
Forms
317 Pharmacy

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10.1021/acs.analchem.4c03163Licence: CC BY

harju-et-al-2025-characterization-of-solid-state-complexities-in-pharmaceutical-materials-via-stimulated-ramanFinal published version, 9.98 MBLicence: CC BY

Molecular Spectroscopy Kumpula (LS-RIA/ LifeSpec)
Vainio, M. (Manager)
Faculty of Science
Facility/equipment: Core Facility
Molecular Spectroscopy Viikki (LS-RIA/ LifeSpec)
Strachan, C. (Manager)
Faculty of Pharmacy
Facility/equipment: Core Facility

Cite this

Harju, E. A., Tomberg, T., Wurr, L., van Rijckeghem, A., Enguita, A. M. A., Dordovic, V., Johansson, N. G., Räikkönen, H., Isomäki, A., Saarinen, J. K. S., Gordon, K. C., van Veen, B., & Strachan, C. J. (2025). Characterization of Solid-State Complexities in Pharmaceutical Materials via Stimulated Raman Scattering Microscopy. Analytical Chemistry, 9627-9637. https://doi.org/10.1021/acs.analchem.4c03163

@article{4844618d350b4297ad1bebe8f35aad86,

title = "Characterization of Solid-State Complexities in Pharmaceutical Materials via Stimulated Raman Scattering Microscopy",

keywords = "Alpha-lactose monohydrate, X-ray-diffraction, Spectroscopy, Spray, Crystallization, Crystallinity, Forms, 317 Pharmacy",

author = "Harju, {Elina A.} and Teemu Tomberg and Lea Wurr and {van Rijckeghem}, Anneleen and Enguita, {Alba M. Arbiol} and Vladimir Dordovic and Johansson, {Niklas G.} and Heikki R{\"a}ikk{\"o}nen and Antti Isom{\"a}ki and Saarinen, {Jukka K. S.} and Gordon, {Keith C.} and {van Veen}, Bert and Strachan, {Clare J.}",

year = "2025",

month = apr,

day = "30",

doi = "10.1021/acs.analchem.4c03163",

language = "English",

pages = "9627--9637",

journal = "Analytical Chemistry",

issn = "0003-2700",

publisher = "American Chemical Society",

}

Harju, EA , Tomberg, T , Wurr, L, van Rijckeghem, A, Enguita, AMA, Dordovic, V, Johansson, NG , Räikkönen, H , Isomäki, A , Saarinen, JKS, Gordon, KC, van Veen, B & Strachan, CJ 2025, 'Characterization of Solid-State Complexities in Pharmaceutical Materials via Stimulated Raman Scattering Microscopy', Analytical Chemistry, pp. 9627-9637. https://doi.org/10.1021/acs.analchem.4c03163

TY - JOUR

T1 - Characterization of Solid-State Complexities in Pharmaceutical Materials via Stimulated Raman Scattering Microscopy

AU - Harju, Elina A.

AU - Tomberg, Teemu

AU - Wurr, Lea

AU - van Rijckeghem, Anneleen

AU - Enguita, Alba M. Arbiol

AU - Dordovic, Vladimir

AU - Johansson, Niklas G.

AU - Räikkönen, Heikki

AU - Isomäki, Antti

AU - Saarinen, Jukka K. S.

AU - Gordon, Keith C.

AU - van Veen, Bert

AU - Strachan, Clare J.

PY - 2025/4/30

Y1 - 2025/4/30

KW - Alpha-lactose monohydrate

KW - X-ray-diffraction

KW - Spectroscopy

KW - Spray

KW - Crystallization

KW - Crystallinity

KW - Forms

KW - 317 Pharmacy

U2 - 10.1021/acs.analchem.4c03163

DO - 10.1021/acs.analchem.4c03163

M3 - Article

C2 - 40302121

SN - 0003-2700

SP - 9627

EP - 9637

JO - Analytical Chemistry

JF - Analytical Chemistry

ER -

Characterization of Solid-State Complexities in Pharmaceutical Materials via Stimulated Raman Scattering Microscopy

Fields of Science

Access to Document

Equipment

Molecular Spectroscopy Kumpula (LS-RIA/ LifeSpec)

Molecular Spectroscopy Viikki (LS-RIA/ LifeSpec)

Cite this