Characterization of the bulk properties of pharmaceutical solids using nonlinear optics: a review

Chris Lee, Clare Strachan, Peter Manson, Thomas Rades

    Research output: Contribution to journalReview ArticleScientificpeer-review

    Abstract

    With the development of stable, compact and reliable pulsed laser sources the field of characterizing materials through their nonlinear optical response has bloomed. Second harmonic generation by non-centrosymmetric crystal structures has provided a new spectroscopic tool of potentially great utility in the pharmaceutical field. The nonlinear optical response of various materials provides a very sensitive technique for the characterization of pharmaceutically interesting bulk compounds and dispersions, and determining their concentrations. This work has potential application for in-line monitoring and quality control of pharmaceutical manufacturing. In this article we have presented an extensive review of the spectroscopic techniques that make use of the nonlinear optical response of solid media. Also, we have presented the results of our own work in this field.
    Original languageEnglish
    JournalJournal of Pharmacy and Pharmacology
    Volume59
    Issue number2
    Pages (from-to)241-250
    Number of pages10
    ISSN0022-3573
    DOIs
    Publication statusPublished - 2007
    MoE publication typeA2 Review article in a scientific journal

    Cite this

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    title = "Characterization of the bulk properties of pharmaceutical solids using nonlinear optics: a review",
    abstract = "With the development of stable, compact and reliable pulsed laser sources the field of characterizing materials through their nonlinear optical response has bloomed. Second harmonic generation by non-centrosymmetric crystal structures has provided a new spectroscopic tool of potentially great utility in the pharmaceutical field. The nonlinear optical response of various materials provides a very sensitive technique for the characterization of pharmaceutically interesting bulk compounds and dispersions, and determining their concentrations. This work has potential application for in-line monitoring and quality control of pharmaceutical manufacturing. In this article we have presented an extensive review of the spectroscopic techniques that make use of the nonlinear optical response of solid media. Also, we have presented the results of our own work in this field.",
    author = "Chris Lee and Clare Strachan and Peter Manson and Thomas Rades",
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    Characterization of the bulk properties of pharmaceutical solids using nonlinear optics : a review. / Lee, Chris; Strachan, Clare; Manson, Peter; Rades, Thomas.

    In: Journal of Pharmacy and Pharmacology, Vol. 59, No. 2, 2007, p. 241-250.

    Research output: Contribution to journalReview ArticleScientificpeer-review

    TY - JOUR

    T1 - Characterization of the bulk properties of pharmaceutical solids using nonlinear optics

    T2 - a review

    AU - Lee, Chris

    AU - Strachan, Clare

    AU - Manson, Peter

    AU - Rades, Thomas

    PY - 2007

    Y1 - 2007

    N2 - With the development of stable, compact and reliable pulsed laser sources the field of characterizing materials through their nonlinear optical response has bloomed. Second harmonic generation by non-centrosymmetric crystal structures has provided a new spectroscopic tool of potentially great utility in the pharmaceutical field. The nonlinear optical response of various materials provides a very sensitive technique for the characterization of pharmaceutically interesting bulk compounds and dispersions, and determining their concentrations. This work has potential application for in-line monitoring and quality control of pharmaceutical manufacturing. In this article we have presented an extensive review of the spectroscopic techniques that make use of the nonlinear optical response of solid media. Also, we have presented the results of our own work in this field.

    AB - With the development of stable, compact and reliable pulsed laser sources the field of characterizing materials through their nonlinear optical response has bloomed. Second harmonic generation by non-centrosymmetric crystal structures has provided a new spectroscopic tool of potentially great utility in the pharmaceutical field. The nonlinear optical response of various materials provides a very sensitive technique for the characterization of pharmaceutically interesting bulk compounds and dispersions, and determining their concentrations. This work has potential application for in-line monitoring and quality control of pharmaceutical manufacturing. In this article we have presented an extensive review of the spectroscopic techniques that make use of the nonlinear optical response of solid media. Also, we have presented the results of our own work in this field.

    U2 - 10.1211/jpp.59.2.0010

    DO - 10.1211/jpp.59.2.0010

    M3 - Review Article

    VL - 59

    SP - 241

    EP - 250

    JO - Journal of Pharmacy and Pharmacology

    JF - Journal of Pharmacy and Pharmacology

    SN - 0022-3573

    IS - 2

    ER -