Chemical analysis using 3D printed glass microfluidics

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Additive manufacturing (3D printing) is a disruptive technology that is changing production systems globally. In addition, microfluidic devices are increasingly being used for chemical analysis and continuous production of chemicals. Printing of materials such as polymers and metals is already a reality, but additive manufacturing of glass for microfluidic systems has received minor attention. We characterize microfluidic devices (channel cross-section dimensions down to a scale of 100 mm) that have been produced by additive manufacturing of molten soda-lime glass in tens of minutes and report their mass spectrometric and Raman spectroscopic analysis examples. The functionality of a microfluidic glass microreactor is shown with online mass spectrometric analysis of linezolid synthesis. Additionally, the performance of a direct infusion device is demonstrated by mass spectrometric analysis of drugs. Finally, the excellent optical quality of the glass structures is demonstrated with in-line Raman spectroscopic measurements. Our results promise a bright future for additively manufactured glass microdevices in diverse fields of science.

Original languageEnglish
JournalAnalytical Methods
Volume11
Issue number13
Pages (from-to)1802-1810
Number of pages9
ISSN1759-9660
DOIs
Publication statusPublished - 7 Apr 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • CHANNEL
  • CHEMISTRY
  • FABRICATION
  • LASER
  • RAMAN-SPECTROSCOPY
  • TOOL
  • 116 Chemical sciences

Cite this

@article{a486bab7f5364112aaef142c0893b332,
title = "Chemical analysis using 3D printed glass microfluidics",
abstract = "Additive manufacturing (3D printing) is a disruptive technology that is changing production systems globally. In addition, microfluidic devices are increasingly being used for chemical analysis and continuous production of chemicals. Printing of materials such as polymers and metals is already a reality, but additive manufacturing of glass for microfluidic systems has received minor attention. We characterize microfluidic devices (channel cross-section dimensions down to a scale of 100 mm) that have been produced by additive manufacturing of molten soda-lime glass in tens of minutes and report their mass spectrometric and Raman spectroscopic analysis examples. The functionality of a microfluidic glass microreactor is shown with online mass spectrometric analysis of linezolid synthesis. Additionally, the performance of a direct infusion device is demonstrated by mass spectrometric analysis of drugs. Finally, the excellent optical quality of the glass structures is demonstrated with in-line Raman spectroscopic measurements. Our results promise a bright future for additively manufactured glass microdevices in diverse fields of science.",
keywords = "CHANNEL, CHEMISTRY, FABRICATION, LASER, RAMAN-SPECTROSCOPY, TOOL, 116 Chemical sciences",
author = "Eran Gal-Or and Yaniv Gershoni and Gianmario Scotti and Nilsson, {Sofia M{\"a}rta Elisabeth} and Saarinen, {Jukka Kalle Samuel} and Jokinen, {Ville Petteri} and Strachan, {Clare Joanna} and {Boije af Genn{\"a}s}, {Per Gustav} and Yli-Kauhaluoma, {Jari Tapani} and Kotiaho, {Ahti Antti Tapio}",
year = "2019",
month = "4",
day = "7",
doi = "10.1039/C8AY01934G",
language = "English",
volume = "11",
pages = "1802--1810",
journal = "Analytical Methods",
issn = "1759-9660",
publisher = "The Royal Society of Chemistry",
number = "13",

}

Chemical analysis using 3D printed glass microfluidics. / Gal-Or, Eran; Gershoni, Yaniv; Scotti, Gianmario; Nilsson, Sofia Märta Elisabeth; Saarinen, Jukka Kalle Samuel; Jokinen, Ville Petteri; Strachan, Clare Joanna; Boije af Gennäs, Per Gustav; Yli-Kauhaluoma, Jari Tapani; Kotiaho, Ahti Antti Tapio.

In: Analytical Methods, Vol. 11, No. 13, 07.04.2019, p. 1802-1810.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Chemical analysis using 3D printed glass microfluidics

AU - Gal-Or, Eran

AU - Gershoni, Yaniv

AU - Scotti, Gianmario

AU - Nilsson, Sofia Märta Elisabeth

AU - Saarinen, Jukka Kalle Samuel

AU - Jokinen, Ville Petteri

AU - Strachan, Clare Joanna

AU - Boije af Gennäs, Per Gustav

AU - Yli-Kauhaluoma, Jari Tapani

AU - Kotiaho, Ahti Antti Tapio

PY - 2019/4/7

Y1 - 2019/4/7

N2 - Additive manufacturing (3D printing) is a disruptive technology that is changing production systems globally. In addition, microfluidic devices are increasingly being used for chemical analysis and continuous production of chemicals. Printing of materials such as polymers and metals is already a reality, but additive manufacturing of glass for microfluidic systems has received minor attention. We characterize microfluidic devices (channel cross-section dimensions down to a scale of 100 mm) that have been produced by additive manufacturing of molten soda-lime glass in tens of minutes and report their mass spectrometric and Raman spectroscopic analysis examples. The functionality of a microfluidic glass microreactor is shown with online mass spectrometric analysis of linezolid synthesis. Additionally, the performance of a direct infusion device is demonstrated by mass spectrometric analysis of drugs. Finally, the excellent optical quality of the glass structures is demonstrated with in-line Raman spectroscopic measurements. Our results promise a bright future for additively manufactured glass microdevices in diverse fields of science.

AB - Additive manufacturing (3D printing) is a disruptive technology that is changing production systems globally. In addition, microfluidic devices are increasingly being used for chemical analysis and continuous production of chemicals. Printing of materials such as polymers and metals is already a reality, but additive manufacturing of glass for microfluidic systems has received minor attention. We characterize microfluidic devices (channel cross-section dimensions down to a scale of 100 mm) that have been produced by additive manufacturing of molten soda-lime glass in tens of minutes and report their mass spectrometric and Raman spectroscopic analysis examples. The functionality of a microfluidic glass microreactor is shown with online mass spectrometric analysis of linezolid synthesis. Additionally, the performance of a direct infusion device is demonstrated by mass spectrometric analysis of drugs. Finally, the excellent optical quality of the glass structures is demonstrated with in-line Raman spectroscopic measurements. Our results promise a bright future for additively manufactured glass microdevices in diverse fields of science.

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KW - CHEMISTRY

KW - FABRICATION

KW - LASER

KW - RAMAN-SPECTROSCOPY

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