Chemoradiotherapy of anal cancer is feasible in elderly patients: treatment results of mitomycin-5-FU combined with radiotherapy at Helsinki University Central Hospital 1992-2003

Kauko Saarilahti, Päivi Arponen, Leila Vaalavirta, Mikko Tenhunen, Carl Blomqvist

    Research output: Contribution to journalArticleScientificpeer-review

    Abstract

    The number of elderly patients with cancer is steadily increasing in developed countries and their treatment is a growing challenge for oncological departments. Anal cancer is the first tumour in which chemoradiotherapy with the intent of organ preservation has largely replaced surgery and is an interesting model of modern multimodal oncological treatment. At the Department of Oncology of the Helsinki University Central Hospital we have treated all patients irrespective of age following the same guidelines if there have been no specific contraindications on the basis of intercurrent diseases. The results suggest that the chemoradiotherapy protocol used in the treatment of anal cancer is reasonably well tolerated in elderly patients and the tumour control is comparable to those achieved in younger patients. After successful cancer therapy the life expectancy in these patients can be very long.
    Original languageEnglish
    JournalActa Oncologica
    Volume45
    Issue number6
    Pages (from-to)736-742
    Number of pages7
    ISSN0284-186X
    DOIs
    Publication statusPublished - 2006
    MoE publication typeA1 Journal article-refereed

    Cite this

    @article{789fb2f201054e52808126b7ff908cf8,
    title = "Chemoradiotherapy of anal cancer is feasible in elderly patients: treatment results of mitomycin-5-FU combined with radiotherapy at Helsinki University Central Hospital 1992-2003",
    abstract = "The number of elderly patients with cancer is steadily increasing in developed countries and their treatment is a growing challenge for oncological departments. Anal cancer is the first tumour in which chemoradiotherapy with the intent of organ preservation has largely replaced surgery and is an interesting model of modern multimodal oncological treatment. At the Department of Oncology of the Helsinki University Central Hospital we have treated all patients irrespective of age following the same guidelines if there have been no specific contraindications on the basis of intercurrent diseases. The results suggest that the chemoradiotherapy protocol used in the treatment of anal cancer is reasonably well tolerated in elderly patients and the tumour control is comparable to those achieved in younger patients. After successful cancer therapy the life expectancy in these patients can be very long.",
    author = "Kauko Saarilahti and P{\"a}ivi Arponen and Leila Vaalavirta and Mikko Tenhunen and Carl Blomqvist",
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    number = "6",

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    Chemoradiotherapy of anal cancer is feasible in elderly patients : treatment results of mitomycin-5-FU combined with radiotherapy at Helsinki University Central Hospital 1992-2003. / Saarilahti, Kauko; Arponen, Päivi; Vaalavirta, Leila; Tenhunen, Mikko; Blomqvist, Carl.

    In: Acta Oncologica, Vol. 45, No. 6, 2006, p. 736-742.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

    T1 - Chemoradiotherapy of anal cancer is feasible in elderly patients

    T2 - treatment results of mitomycin-5-FU combined with radiotherapy at Helsinki University Central Hospital 1992-2003

    AU - Saarilahti, Kauko

    AU - Arponen, Päivi

    AU - Vaalavirta, Leila

    AU - Tenhunen, Mikko

    AU - Blomqvist, Carl

    PY - 2006

    Y1 - 2006

    N2 - The number of elderly patients with cancer is steadily increasing in developed countries and their treatment is a growing challenge for oncological departments. Anal cancer is the first tumour in which chemoradiotherapy with the intent of organ preservation has largely replaced surgery and is an interesting model of modern multimodal oncological treatment. At the Department of Oncology of the Helsinki University Central Hospital we have treated all patients irrespective of age following the same guidelines if there have been no specific contraindications on the basis of intercurrent diseases. The results suggest that the chemoradiotherapy protocol used in the treatment of anal cancer is reasonably well tolerated in elderly patients and the tumour control is comparable to those achieved in younger patients. After successful cancer therapy the life expectancy in these patients can be very long.

    AB - The number of elderly patients with cancer is steadily increasing in developed countries and their treatment is a growing challenge for oncological departments. Anal cancer is the first tumour in which chemoradiotherapy with the intent of organ preservation has largely replaced surgery and is an interesting model of modern multimodal oncological treatment. At the Department of Oncology of the Helsinki University Central Hospital we have treated all patients irrespective of age following the same guidelines if there have been no specific contraindications on the basis of intercurrent diseases. The results suggest that the chemoradiotherapy protocol used in the treatment of anal cancer is reasonably well tolerated in elderly patients and the tumour control is comparable to those achieved in younger patients. After successful cancer therapy the life expectancy in these patients can be very long.

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    JF - Acta Oncologica

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