Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

Nhlbi Trans-Omics Precision Med To; Pradeep Natarajan; Akhil Pampana; Sarah E. Graham; Sanni E. Ruotsalainen; James A. Perry; Paul S. de Vries; Jai G. Broome; Aarno Palotie; Samuli Ripatti; Mark Daly; Jaakko Kaprio; Kari Pulkki; Samuli Ripatti; Johannes Kettunen; Reijo Laaksonen; Juha Rinne; Sampsa Pikkarainen; Kari Eklund; Paula Kauppi; Juha Sinisalo; Marja-Riitta Taskinen; Tiinamaija Tuomi; Heikki Joensuu; Tuomo Meretoja; Lauri Aaltonen; Joni Turunen; Sanna Seitsonen; Katariina Hannula-Jouppi; Anu Jalanko; Risto Kajanne; Ulrike Lyhs; Mari Kaunisto; Mitja Kurki; Juha Karjalainen; Aki Havulinna; Priit Palta; Pietro Della Briotta Parolo; Jarmo Harju; Arto Lehisto; Andrea Ganna; Vincent Llorens; Miika Koskinen; Sami Heikkinen; Anu Loukola; Kati Donner; Javier Nunez-Fontarnau; Georg Brein; Hannele Laivuori; Tuomo Kiiskinen

doi:10.1038/s41467-021-22339-1

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

Nhlbi Trans-Omics Precision Med To, Pradeep Natarajan, Akhil Pampana, Sarah E. Graham, Sanni E. Ruotsalainen, James A. Perry, Paul S. de Vries, Jai G. Broome, Aarno Palotie, Samuli Ripatti, Mark Daly, Jaakko Kaprio, Kari Pulkki, Samuli Ripatti, Johannes Kettunen, Reijo Laaksonen, Juha Rinne, Sampsa Pikkarainen, Kari Eklund, Paula KauppiJuha Sinisalo, Marja-Riitta Taskinen, Tiinamaija Tuomi, Heikki Joensuu, Tuomo Meretoja, Lauri Aaltonen, Joni Turunen, Sanna Seitsonen, Katariina Hannula-Jouppi, Anu Jalanko, Risto Kajanne, Ulrike Lyhs, Mari Kaunisto, Mitja Kurki, Juha Karjalainen, Aki Havulinna, Priit Palta, Pietro Della Briotta Parolo, Jarmo Harju, Arto Lehisto, Andrea Ganna, Vincent Llorens, Miika Koskinen, Sami Heikkinen, Anu Loukola, Kati Donner, Javier Nunez-Fontarnau, Georg Brein, Hannele Laivuori, Tuomo Kiiskinen

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	2182
Journal	Nature Communications
Volume	12
Issue number	1
Number of pages	14
ISSN	2041-1723
DOIs	https://doi.org/10.1038/s41467-021-22339-1
Publication status	Published - 12 Apr 2021
MoE publication type	A1 Journal article-refereed

Fields of Science

DENSITY-LIPOPROTEIN-CHOLESTEROL
CHOLESTEROL/APOLIPOPROTEIN-B RATIO
GENOME-WIDE ASSOCIATION
CORONARY-ARTERY-DISEASE
APOLIPOPROTEIN-B
X-CHROMOSOME
GENETIC-VARIANTS
FAT DISTRIBUTION
RISK
PCSK9
1184 Genetics, developmental biology, physiology

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10.1038/s41467-021-22339-1

s41467-021-22339-1Final published version, 1.72 MBLicence: CC BY

Cite this

Nhlbi Trans-Omics Precision Med To, Natarajan, P., Pampana, A., Graham, S. E., Ruotsalainen, S. E., Perry, J. A., de Vries, P. S., Broome, J. G., Palotie, A., Ripatti, S., Daly, M., Kaprio, J., Pulkki, K., Ripatti, S., Kettunen, J., Laaksonen, R., Rinne, J., Pikkarainen, S., Eklund, K., ... Kiiskinen, T. (2021). Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices. Nature Communications, 12(1), Article 2182. https://doi.org/10.1038/s41467-021-22339-1

@article{52b6d395f2094ea3b7fc760f437b2014,

title = "Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices",

keywords = "DENSITY-LIPOPROTEIN-CHOLESTEROL, CHOLESTEROL/APOLIPOPROTEIN-B RATIO, GENOME-WIDE ASSOCIATION, CORONARY-ARTERY-DISEASE, APOLIPOPROTEIN-B, X-CHROMOSOME, GENETIC-VARIANTS, FAT DISTRIBUTION, RISK, PCSK9, 1184 Genetics, developmental biology, physiology",

author = "{Nhlbi Trans-Omics Precision Med To} and Pradeep Natarajan and Akhil Pampana and Graham, {Sarah E.} and Ruotsalainen, {Sanni E.} and Perry, {James A.} and {de Vries}, {Paul S.} and Broome, {Jai G.} and Aarno Palotie and Samuli Ripatti and Mark Daly and Jaakko Kaprio and Kari Pulkki and Samuli Ripatti and Johannes Kettunen and Reijo Laaksonen and Juha Rinne and Sampsa Pikkarainen and Kari Eklund and Paula Kauppi and Juha Sinisalo and Marja-Riitta Taskinen and Tiinamaija Tuomi and Heikki Joensuu and Tuomo Meretoja and Lauri Aaltonen and Joni Turunen and Sanna Seitsonen and Katariina Hannula-Jouppi and Anu Jalanko and Risto Kajanne and Ulrike Lyhs and Mari Kaunisto and Mitja Kurki and Juha Karjalainen and Aki Havulinna and Priit Palta and Parolo, {Pietro Della Briotta} and Jarmo Harju and Arto Lehisto and Andrea Ganna and Vincent Llorens and Miika Koskinen and Sami Heikkinen and Anu Loukola and Kati Donner and Javier Nunez-Fontarnau and Georg Brein and Hannele Laivuori and Tuomo Kiiskinen",

year = "2021",

month = apr,

day = "12",

doi = "10.1038/s41467-021-22339-1",

language = "English",

volume = "12",

journal = "Nature Communications",

issn = "2041-1723",

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Nhlbi Trans-Omics Precision Med To, Natarajan, P, Pampana, A, Graham, SE, Ruotsalainen, SE, Perry, JA, de Vries, PS, Broome, JG, Palotie, A , Ripatti, S , Daly, M , Kaprio, J , Pulkki, K , Ripatti, S, Kettunen, J, Laaksonen, R, Rinne, J, Pikkarainen, S, Eklund, K , Kauppi, P , Sinisalo, J , Taskinen, M-R , Tuomi, T , Joensuu, H , Meretoja, T , Aaltonen, L, Turunen, J, Seitsonen, S, Hannula-Jouppi, K , Jalanko, A , Kajanne, R, Lyhs, U, Kaunisto, M, Kurki, M, Karjalainen, J , Havulinna, A , Palta, P , Parolo, PDB, Harju, J, Lehisto, A , Ganna, A , Llorens, V , Koskinen, M, Heikkinen, S, Loukola, A , Donner, K , Nunez-Fontarnau, J, Brein, G, Laivuori, H & Kiiskinen, T 2021, 'Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices', Nature Communications, vol. 12, no. 1, 2182. https://doi.org/10.1038/s41467-021-22339-1

TY - JOUR

T1 - Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

AU - Nhlbi Trans-Omics Precision Med To

AU - Natarajan, Pradeep

AU - Pampana, Akhil

AU - Graham, Sarah E.

AU - Ruotsalainen, Sanni E.

AU - Perry, James A.

AU - de Vries, Paul S.

AU - Broome, Jai G.

AU - Palotie, Aarno

AU - Ripatti, Samuli

AU - Daly, Mark

AU - Kaprio, Jaakko

AU - Pulkki, Kari

AU - Ripatti, Samuli

AU - Kettunen, Johannes

AU - Laaksonen, Reijo

AU - Rinne, Juha

AU - Pikkarainen, Sampsa

AU - Eklund, Kari

AU - Kauppi, Paula

AU - Sinisalo, Juha

AU - Taskinen, Marja-Riitta

AU - Tuomi, Tiinamaija

AU - Joensuu, Heikki

AU - Meretoja, Tuomo

AU - Aaltonen, Lauri

AU - Turunen, Joni

AU - Seitsonen, Sanna

AU - Hannula-Jouppi, Katariina

AU - Jalanko, Anu

AU - Kajanne, Risto

AU - Lyhs, Ulrike

AU - Kaunisto, Mari

AU - Kurki, Mitja

AU - Karjalainen, Juha

AU - Havulinna, Aki

AU - Palta, Priit

AU - Parolo, Pietro Della Briotta

AU - Harju, Jarmo

AU - Lehisto, Arto

AU - Ganna, Andrea

AU - Llorens, Vincent

AU - Koskinen, Miika

AU - Heikkinen, Sami

AU - Loukola, Anu

AU - Donner, Kati

AU - Nunez-Fontarnau, Javier

AU - Brein, Georg

AU - Laivuori, Hannele

AU - Kiiskinen, Tuomo

PY - 2021/4/12

Y1 - 2021/4/12

KW - DENSITY-LIPOPROTEIN-CHOLESTEROL

KW - CHOLESTEROL/APOLIPOPROTEIN-B RATIO

KW - GENOME-WIDE ASSOCIATION

KW - CORONARY-ARTERY-DISEASE

KW - APOLIPOPROTEIN-B

KW - X-CHROMOSOME

KW - GENETIC-VARIANTS

KW - FAT DISTRIBUTION

KW - RISK

KW - PCSK9

KW - 1184 Genetics, developmental biology, physiology

U2 - 10.1038/s41467-021-22339-1

DO - 10.1038/s41467-021-22339-1

M3 - Article

SN - 2041-1723

VL - 12

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 2182

ER -