Chronic Alcohol Causes Alteration of Lipidome Profiling in Brain

Liang Wang, Menglu Li, Qian Bu, Hongchun Li, Wei Xu, Chunqi Liu, Hui Gu, Jiamei Zhang, Xuemei Wan, Yinglan Zhao, Xiaobo Cen

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Much efforts have been tried to clarify the molecular mechanism of alcohol-induced brain damage from the perspective of genome and protein; however, the effect of chronic alcohol exposure on global lipid profiling of brain is unclear. In the present study, by using Q-TOF/MS-based lipidomics approach, we investigated the comprehensive lipidome profiling of brain from the rats orally administrated with alcohol daily, continuously for one year. Through systematically analysis of all lipids in prefrontal cortex (PFC) and striatum region, we found that long-term alcohol exposure profoundly modified brain lipidome profiling. Notably, three kinds of lipid classes, glycerophospholipid (GP), glycerolipid (GL) and fatty acyls (FA), were significantly increased in these two brain regions. Interestingly, most of the modified lipids were involved in synthetic pathways of endoplasmic reticulum (ER), which may result in ER stress-related metabolic disruption. Moreover, alcohol-modified lipid species displayed long length of carbon chain with high degree of unsaturation. Taken together, our results firstly present that chronic alcohol exposure markedly modifies brain lipidomic profiling, which may activate ER stress and eventually result in neurotoxicity. These findings provide a new insight into the mechanism of alcohol-related brain damage.
Original languageEnglish
JournalToxicology Letters
ISSN0378-4274
DOIs
Publication statusPublished - 11 May 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Alcohol abuse
  • Lipidome profiling
  • ER stress
  • 3111 Biomedicine

Cite this

Wang, Liang ; Li, Menglu ; Bu, Qian ; Li, Hongchun ; Xu, Wei ; Liu, Chunqi ; Gu, Hui ; Zhang, Jiamei ; Wan, Xuemei ; Zhao, Yinglan ; Cen, Xiaobo. / Chronic Alcohol Causes Alteration of Lipidome Profiling in Brain. In: Toxicology Letters. 2019.
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title = "Chronic Alcohol Causes Alteration of Lipidome Profiling in Brain",
abstract = "Much efforts have been tried to clarify the molecular mechanism of alcohol-induced brain damage from the perspective of genome and protein; however, the effect of chronic alcohol exposure on global lipid profiling of brain is unclear. In the present study, by using Q-TOF/MS-based lipidomics approach, we investigated the comprehensive lipidome profiling of brain from the rats orally administrated with alcohol daily, continuously for one year. Through systematically analysis of all lipids in prefrontal cortex (PFC) and striatum region, we found that long-term alcohol exposure profoundly modified brain lipidome profiling. Notably, three kinds of lipid classes, glycerophospholipid (GP), glycerolipid (GL) and fatty acyls (FA), were significantly increased in these two brain regions. Interestingly, most of the modified lipids were involved in synthetic pathways of endoplasmic reticulum (ER), which may result in ER stress-related metabolic disruption. Moreover, alcohol-modified lipid species displayed long length of carbon chain with high degree of unsaturation. Taken together, our results firstly present that chronic alcohol exposure markedly modifies brain lipidomic profiling, which may activate ER stress and eventually result in neurotoxicity. These findings provide a new insight into the mechanism of alcohol-related brain damage.",
keywords = "Alcohol abuse, Lipidome profiling, ER stress, 3111 Biomedicine",
author = "Liang Wang and Menglu Li and Qian Bu and Hongchun Li and Wei Xu and Chunqi Liu and Hui Gu and Jiamei Zhang and Xuemei Wan and Yinglan Zhao and Xiaobo Cen",
year = "2019",
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Wang, L, Li, M, Bu, Q, Li, H, Xu, W, Liu, C, Gu, H, Zhang, J, Wan, X, Zhao, Y & Cen, X 2019, 'Chronic Alcohol Causes Alteration of Lipidome Profiling in Brain' Toxicology Letters. https://doi.org/10.1016/j.toxlet.2019.05.010

Chronic Alcohol Causes Alteration of Lipidome Profiling in Brain. / Wang, Liang; Li, Menglu; Bu, Qian; Li, Hongchun; Xu, Wei; Liu, Chunqi; Gu, Hui; Zhang, Jiamei; Wan, Xuemei; Zhao, Yinglan; Cen, Xiaobo.

In: Toxicology Letters, 11.05.2019.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Chronic Alcohol Causes Alteration of Lipidome Profiling in Brain

AU - Wang, Liang

AU - Li, Menglu

AU - Bu, Qian

AU - Li, Hongchun

AU - Xu, Wei

AU - Liu, Chunqi

AU - Gu, Hui

AU - Zhang, Jiamei

AU - Wan, Xuemei

AU - Zhao, Yinglan

AU - Cen, Xiaobo

PY - 2019/5/11

Y1 - 2019/5/11

N2 - Much efforts have been tried to clarify the molecular mechanism of alcohol-induced brain damage from the perspective of genome and protein; however, the effect of chronic alcohol exposure on global lipid profiling of brain is unclear. In the present study, by using Q-TOF/MS-based lipidomics approach, we investigated the comprehensive lipidome profiling of brain from the rats orally administrated with alcohol daily, continuously for one year. Through systematically analysis of all lipids in prefrontal cortex (PFC) and striatum region, we found that long-term alcohol exposure profoundly modified brain lipidome profiling. Notably, three kinds of lipid classes, glycerophospholipid (GP), glycerolipid (GL) and fatty acyls (FA), were significantly increased in these two brain regions. Interestingly, most of the modified lipids were involved in synthetic pathways of endoplasmic reticulum (ER), which may result in ER stress-related metabolic disruption. Moreover, alcohol-modified lipid species displayed long length of carbon chain with high degree of unsaturation. Taken together, our results firstly present that chronic alcohol exposure markedly modifies brain lipidomic profiling, which may activate ER stress and eventually result in neurotoxicity. These findings provide a new insight into the mechanism of alcohol-related brain damage.

AB - Much efforts have been tried to clarify the molecular mechanism of alcohol-induced brain damage from the perspective of genome and protein; however, the effect of chronic alcohol exposure on global lipid profiling of brain is unclear. In the present study, by using Q-TOF/MS-based lipidomics approach, we investigated the comprehensive lipidome profiling of brain from the rats orally administrated with alcohol daily, continuously for one year. Through systematically analysis of all lipids in prefrontal cortex (PFC) and striatum region, we found that long-term alcohol exposure profoundly modified brain lipidome profiling. Notably, three kinds of lipid classes, glycerophospholipid (GP), glycerolipid (GL) and fatty acyls (FA), were significantly increased in these two brain regions. Interestingly, most of the modified lipids were involved in synthetic pathways of endoplasmic reticulum (ER), which may result in ER stress-related metabolic disruption. Moreover, alcohol-modified lipid species displayed long length of carbon chain with high degree of unsaturation. Taken together, our results firstly present that chronic alcohol exposure markedly modifies brain lipidomic profiling, which may activate ER stress and eventually result in neurotoxicity. These findings provide a new insight into the mechanism of alcohol-related brain damage.

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KW - Lipidome profiling

KW - ER stress

KW - 3111 Biomedicine

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