Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr192 and compromises its cardioprotective activity

Ilona Kareinen, Marc Baumann, Su Duy Nguyen, Katariina Maaninka, Andrey Anisimov, Minoru Tozuka, Matti Jauhiainen, Miriam Lee-Rueckert, Petri T. Kovanen

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Lipid Research
Volume59
Issue number6
Pages (from-to)945-957
Number of pages13
ISSN0022-2275
DOIs
Publication statusPublished - Jun 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • apolipoproteins
  • carboxyl-terminal truncation
  • cardiac ischemia
  • cells and tissues
  • endothelial cells
  • diseases/atherosclerosis
  • high density lipoproteins
  • reconstituted high density lipoprotein
  • mass spectrometry
  • proteolysis
  • APOLIPOPROTEIN-A-I
  • HIGH-DENSITY-LIPOPROTEIN
  • REVERSE CHOLESTEROL TRANSPORT
  • AORTIC INTIMAL FLUID
  • MYOCARDIAL ISCHEMIA/REPERFUSION
  • VASCULAR-PERMEABILITY
  • ENDOTHELIAL REPAIR
  • OXIDATIVE STRESS
  • CORONARY-ARTERY
  • HEART-DISEASE
  • 1182 Biochemistry, cell and molecular biology
  • 3121 Internal medicine

Cite this

@article{252ae48399b043a1bf041d7591106a32,
title = "Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr192 and compromises its cardioprotective activity",
keywords = "apolipoproteins, carboxyl-terminal truncation, cardiac ischemia, cells and tissues, endothelial cells, diseases/atherosclerosis, high density lipoproteins, reconstituted high density lipoprotein, mass spectrometry, proteolysis, APOLIPOPROTEIN-A-I, HIGH-DENSITY-LIPOPROTEIN, REVERSE CHOLESTEROL TRANSPORT, AORTIC INTIMAL FLUID, MYOCARDIAL ISCHEMIA/REPERFUSION, VASCULAR-PERMEABILITY, ENDOTHELIAL REPAIR, OXIDATIVE STRESS, CORONARY-ARTERY, HEART-DISEASE, 1182 Biochemistry, cell and molecular biology, 3121 Internal medicine",
author = "Ilona Kareinen and Marc Baumann and {Su Duy Nguyen} and Katariina Maaninka and Andrey Anisimov and Minoru Tozuka and Matti Jauhiainen and Miriam Lee-Rueckert and Kovanen, {Petri T.}",
year = "2018",
month = "6",
doi = "10.1194/jlr.M077503",
language = "English",
volume = "59",
pages = "945--957",
journal = "Journal of Lipid Research",
issn = "0022-2275",
publisher = "American Society for Biochemistry and Molecular Biology",
number = "6",

}

Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr192 and compromises its cardioprotective activity. / Kareinen, Ilona; Baumann, Marc; Su Duy Nguyen, ; Maaninka, Katariina; Anisimov, Andrey; Tozuka, Minoru; Jauhiainen, Matti; Lee-Rueckert, Miriam; Kovanen, Petri T.

In: Journal of Lipid Research, Vol. 59, No. 6, 06.2018, p. 945-957.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr192 and compromises its cardioprotective activity

AU - Kareinen, Ilona

AU - Baumann, Marc

AU - Su Duy Nguyen, null

AU - Maaninka, Katariina

AU - Anisimov, Andrey

AU - Tozuka, Minoru

AU - Jauhiainen, Matti

AU - Lee-Rueckert, Miriam

AU - Kovanen, Petri T.

PY - 2018/6

Y1 - 2018/6

KW - apolipoproteins

KW - carboxyl-terminal truncation

KW - cardiac ischemia

KW - cells and tissues

KW - endothelial cells

KW - diseases/atherosclerosis

KW - high density lipoproteins

KW - reconstituted high density lipoprotein

KW - mass spectrometry

KW - proteolysis

KW - APOLIPOPROTEIN-A-I

KW - HIGH-DENSITY-LIPOPROTEIN

KW - REVERSE CHOLESTEROL TRANSPORT

KW - AORTIC INTIMAL FLUID

KW - MYOCARDIAL ISCHEMIA/REPERFUSION

KW - VASCULAR-PERMEABILITY

KW - ENDOTHELIAL REPAIR

KW - OXIDATIVE STRESS

KW - CORONARY-ARTERY

KW - HEART-DISEASE

KW - 1182 Biochemistry, cell and molecular biology

KW - 3121 Internal medicine

U2 - 10.1194/jlr.M077503

DO - 10.1194/jlr.M077503

M3 - Article

VL - 59

SP - 945

EP - 957

JO - Journal of Lipid Research

JF - Journal of Lipid Research

SN - 0022-2275

IS - 6

ER -