Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr192 and compromises its cardioprotective activity

Ilona Kareinen, Marc Baumann, Su Duy Nguyen, Katariina Maaninka, Andrey Anisimov, Minoru Tozuka, Matti Jauhiainen, Miriam Lee-Rueckert, Petri T. Kovanen

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Lipid Research
Volume59
Issue number6
Pages (from-to)945-957
Number of pages13
ISSN0022-2275
DOIs
Publication statusPublished - Jun 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • apolipoproteins
  • carboxyl-terminal truncation
  • cardiac ischemia
  • cells and tissues
  • endothelial cells
  • diseases/atherosclerosis
  • high density lipoproteins
  • reconstituted high density lipoprotein
  • mass spectrometry
  • proteolysis
  • APOLIPOPROTEIN-A-I
  • HIGH-DENSITY-LIPOPROTEIN
  • REVERSE CHOLESTEROL TRANSPORT
  • AORTIC INTIMAL FLUID
  • MYOCARDIAL ISCHEMIA/REPERFUSION
  • VASCULAR-PERMEABILITY
  • ENDOTHELIAL REPAIR
  • OXIDATIVE STRESS
  • CORONARY-ARTERY
  • HEART-DISEASE
  • 1182 Biochemistry, cell and molecular biology
  • 3121 Internal medicine

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