Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalDrug Metabolism and Disposition
Volume47
Issue number4
Pages (from-to)377-385
Number of pages9
ISSN0090-9556
DOIs
Publication statusPublished - 1 Apr 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • DRUG-DRUG INTERACTION
  • TRANSPORTING POLYPEPTIDE 1B1
  • PLASMA-CONCENTRATIONS
  • DEPENDENT INHIBITOR
  • MARKEDLY INCREASES
  • UGT2B10 GENOTYPE
  • CYP2C8
  • PHARMACOKINETICS
  • GLUCURONIDATION
  • METABOLISM
  • 317 Pharmacy
  • 3111 Biomedicine

Cite this

@article{c07f551aad5f49618c0842e8f3efe377,
title = "Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans",
keywords = "DRUG-DRUG INTERACTION, TRANSPORTING POLYPEPTIDE 1B1, PLASMA-CONCENTRATIONS, DEPENDENT INHIBITOR, MARKEDLY INCREASES, UGT2B10 GENOTYPE, CYP2C8, PHARMACOKINETICS, GLUCURONIDATION, METABOLISM, 317 Pharmacy, 3111 Biomedicine",
author = "Itkonen, {Matti K.} and Aleksi Tornio and Mikko Neuvonen and Neuvonen, {Pertti J.} and Mikko Niemi and Backman, {Janne T.}",
year = "2019",
month = "4",
day = "1",
doi = "10.1124/dmd.118.084665",
language = "English",
volume = "47",
pages = "377--385",
journal = "Drug Metabolism and Disposition",
issn = "1521-009X",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "4",

}

TY - JOUR

T1 - Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans

AU - Itkonen, Matti K.

AU - Tornio, Aleksi

AU - Neuvonen, Mikko

AU - Neuvonen, Pertti J.

AU - Niemi, Mikko

AU - Backman, Janne T.

PY - 2019/4/1

Y1 - 2019/4/1

KW - DRUG-DRUG INTERACTION

KW - TRANSPORTING POLYPEPTIDE 1B1

KW - PLASMA-CONCENTRATIONS

KW - DEPENDENT INHIBITOR

KW - MARKEDLY INCREASES

KW - UGT2B10 GENOTYPE

KW - CYP2C8

KW - PHARMACOKINETICS

KW - GLUCURONIDATION

KW - METABOLISM

KW - 317 Pharmacy

KW - 3111 Biomedicine

U2 - 10.1124/dmd.118.084665

DO - 10.1124/dmd.118.084665

M3 - Article

VL - 47

SP - 377

EP - 385

JO - Drug Metabolism and Disposition

JF - Drug Metabolism and Disposition

SN - 1521-009X

IS - 4

ER -