Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalDrug Metabolism and Disposition
Volume47
Issue number4
Pages (from-to)377-385
Number of pages9
ISSN0090-9556
DOIs
Publication statusPublished - 1 Apr 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • DRUG-DRUG INTERACTION
  • TRANSPORTING POLYPEPTIDE 1B1
  • PLASMA-CONCENTRATIONS
  • DEPENDENT INHIBITOR
  • MARKEDLY INCREASES
  • UGT2B10 GENOTYPE
  • CYP2C8
  • PHARMACOKINETICS
  • GLUCURONIDATION
  • METABOLISM
  • 317 Pharmacy
  • 3111 Biomedicine

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