Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalDrug Metabolism and Disposition
Volume43
Issue number11
Pages (from-to)1655-1660
Number of pages6
ISSN0090-9556
DOIs
Publication statusPublished - Nov 2015
MoE publication typeA1 Journal article-refereed

Fields of Science

  • POLYMORPHISM MARKEDLY AFFECTS
  • DRUG-DRUG INTERACTIONS
  • HMG-COA REDUCTASE
  • GRAPEFRUIT JUICE
  • INDUCED MYOPATHY
  • SLCO1B1 POLYMORPHISM
  • HEPATIC-UPTAKE
  • HEART-DISEASE
  • HYDROXY ACID
  • IN-VITRO
  • 3111 Biomedicine

Cite this

@article{70b196ae210341289ba92d51ef77346a,
title = "Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin",
keywords = "POLYMORPHISM MARKEDLY AFFECTS, DRUG-DRUG INTERACTIONS, HMG-COA REDUCTASE, GRAPEFRUIT JUICE, INDUCED MYOPATHY, SLCO1B1 POLYMORPHISM, HEPATIC-UPTAKE, HEART-DISEASE, HYDROXY ACID, IN-VITRO, 3111 Biomedicine",
author = "Itkonen, {Matti K.} and Aleksi Tornio and Mikko Neuvonen and Neuvonen, {Pertti J.} and Mikko Niemi and Backman, {Janne T.}",
year = "2015",
month = "11",
doi = "10.1124/dmd.115.065938",
language = "English",
volume = "43",
pages = "1655--1660",
journal = "Drug Metabolism and Disposition",
issn = "1521-009X",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "11",

}

TY - JOUR

T1 - Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin

AU - Itkonen, Matti K.

AU - Tornio, Aleksi

AU - Neuvonen, Mikko

AU - Neuvonen, Pertti J.

AU - Niemi, Mikko

AU - Backman, Janne T.

PY - 2015/11

Y1 - 2015/11

KW - POLYMORPHISM MARKEDLY AFFECTS

KW - DRUG-DRUG INTERACTIONS

KW - HMG-COA REDUCTASE

KW - GRAPEFRUIT JUICE

KW - INDUCED MYOPATHY

KW - SLCO1B1 POLYMORPHISM

KW - HEPATIC-UPTAKE

KW - HEART-DISEASE

KW - HYDROXY ACID

KW - IN-VITRO

KW - 3111 Biomedicine

U2 - 10.1124/dmd.115.065938

DO - 10.1124/dmd.115.065938

M3 - Article

VL - 43

SP - 1655

EP - 1660

JO - Drug Metabolism and Disposition

JF - Drug Metabolism and Disposition

SN - 1521-009X

IS - 11

ER -