Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Zehua Liu; Yunzhan  Li; Wei Li; Wenhua Lian; Marianna Kemell; Sami Hietala; Patricia Figueiredo; Li Li; Ermei Mäkilä; Ming  Ma; Jarno Salonen; Jouni T. Hirvonen; Dongfei Liu; Hongbo Zhang; Xianming  Deng; Helder A. Santos

doi:10.1039/c8mh01145a

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Zehua Liu, Yunzhan Li, Wei Li, Wenhua Lian, Marianna Kemell, Sami Hietala, Patricia Figueiredo, Li Li, Ermei Mäkilä, Ming Ma, Jarno Salonen, Jouni T. Hirvonen, Dongfei Liu, Hongbo Zhang, Xianming Deng, Helder A. Santos

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.

Original language	English
Journal	Materials Horizons
Volume	6
Issue number	2
Pages (from-to)	385-393
Number of pages	9
ISSN	2051-6347
DOIs	https://doi.org/10.1039/c8mh01145a
Publication status	Published - 1 Feb 2019
MoE publication type	A1 Journal article-refereed

Fields of Science

OXIDIZED DEXTRAN
NANOPARTICLES
ANGIOGENESIS
VEGF
DEFEROXAMINE
HYDROGEL
GEL
EXPRESSION
DELIVERY
RELEASE
116 Chemical sciences
317 Pharmacy

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Cite this

Liu, Z., Li, Y., Li, W., Lian, W., Kemell, M., Hietala, S., Figueiredo, P., Li, L., Mäkilä, E., Ma, M., Salonen, J., Hirvonen, J. T., Liu, D., Zhang, H., Deng, X., & Santos, H. A. (2019). Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing. Materials Horizons, 6(2), 385-393. https://doi.org/10.1039/c8mh01145a

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title = "Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing",

abstract = "Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.",

keywords = "OXIDIZED DEXTRAN, NANOPARTICLES, ANGIOGENESIS, VEGF, DEFEROXAMINE, HYDROGEL, GEL, EXPRESSION, DELIVERY, RELEASE, 116 Chemical sciences, 317 Pharmacy",

author = "Zehua Liu and Yunzhan Li and Wei Li and Wenhua Lian and Marianna Kemell and Sami Hietala and Patricia Figueiredo and Li Li and Ermei M{\"a}kil{\"a} and Ming Ma and Jarno Salonen and Hirvonen, {Jouni T.} and Dongfei Liu and Hongbo Zhang and Xianming Deng and Santos, {Helder A.}",

year = "2019",

month = feb,

day = "1",

doi = "10.1039/c8mh01145a",

language = "English",

volume = "6",

pages = "385--393",

journal = "Materials Horizons",

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publisher = "Royal Society of Chemistry",

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}

Liu, Z, Li, Y, Li, W, Lian, W, Kemell, M , Hietala, S , Figueiredo, P, Li, L, Mäkilä, E, Ma, M, Salonen, J, Hirvonen, JT , Liu, D, Zhang, H, Deng, X & Santos, HA 2019, 'Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing', Materials Horizons, vol. 6, no. 2, pp. 385-393. https://doi.org/10.1039/c8mh01145a

TY - JOUR

T1 - Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

AU - Liu, Zehua

AU - Li, Yunzhan

AU - Li, Wei

AU - Lian, Wenhua

AU - Kemell, Marianna

AU - Hietala, Sami

AU - Figueiredo, Patricia

AU - Li, Li

AU - Mäkilä, Ermei

AU - Ma, Ming

AU - Salonen, Jarno

AU - Hirvonen, Jouni T.

AU - Liu, Dongfei

AU - Zhang, Hongbo

AU - Deng, Xianming

AU - Santos, Helder A.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.

AB - Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.

KW - OXIDIZED DEXTRAN

KW - NANOPARTICLES

KW - ANGIOGENESIS

KW - VEGF

KW - DEFEROXAMINE

KW - HYDROGEL

KW - GEL

KW - EXPRESSION

KW - DELIVERY

KW - RELEASE

KW - 116 Chemical sciences

KW - 317 Pharmacy

U2 - 10.1039/c8mh01145a

DO - 10.1039/c8mh01145a

M3 - Article

VL - 6

SP - 385

EP - 393

JO - Materials Horizons

JF - Materials Horizons

SN - 2051-6347

IS - 2

ER -