Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Zehua Liu, Yunzhan Li, Wei Li, Wenhua Lian, Marianna Kemell, Sami Hietala, Patricia Figueiredo, Li Li, Ermei Mäkilä, Ming Ma, Jarno Salonen, Jouni T. Hirvonen, Dongfei Liu, Hongbo Zhang, Xianming Deng, Helder A. Santos

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.

Original languageEnglish
JournalMaterials Horizons
Volume6
Issue number2
Pages (from-to)385-393
Number of pages9
ISSN2051-6347
DOIs
Publication statusPublished - 1 Feb 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • OXIDIZED DEXTRAN
  • NANOPARTICLES
  • ANGIOGENESIS
  • VEGF
  • DEFEROXAMINE
  • HYDROGEL
  • GEL
  • EXPRESSION
  • DELIVERY
  • RELEASE
  • 116 Chemical sciences
  • 317 Pharmacy

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