Combination Therapy of Killing Diseases by Injectable Hydrogels: From Concept to Medical Applications

Fatemeh Poustchi, Hamed Amani, Zainab Ahmadian, Seyyed Vahid Niknezhad, Soraya Mehrabi, Hélder A. Santos, Mohammad-Ali Shahbazi

Research output: Contribution to journalReview Articlepeer-review

Abstract

The complexity of hard‐to‐treat diseases strongly undermines the therapeutic potential of available treatment options. Therefore, a paradigm shift from monotherapy toward combination therapy has been observed in clinical research to improve the efficiency of available treatment options. The advantages of combination therapy include the possibility of synchronous alteration of different biological pathways, reducing the required effective therapeutic dose, reducing drug resistance, and lowering the overall costs of treatment. The tunable physical properties, excellent biocompatibility, facile preparation, and ease of administration with minimal invasiveness of injectable hydrogels (IHs) have made them excellent candidates to solve the clinical and pharmacological limitations of present systems for multitherapy by direct delivery of therapeutic payloads and improving therapeutic responses through the formation of depots containing drugs, genes, cells, or a combination of them in the body after a single injection. In this review, currently available methods for the design and fabrication of IHs are systematically discussed in the first section. Next, as a step toward establishing IHs for future multimodal synergistic therapies, recent advances in cancer combination therapy, wound healing, and tissue engineering are addressed in detail in the following sections. Finally, opportunities and challenges associated with IHs for multitherapy are listed and further discussed.
Original languageEnglish
Article number2001571
JournalAdvanced Healthcare Materials
Volume10
Issue number3
Number of pages30
ISSN2192-2640
DOIs
Publication statusPublished - 3 Feb 2021
MoE publication typeA2 Review article in a scientific journal

Fields of Science

  • BIOMIMETIC SCAFFOLDS
  • CLICK CROSS-LINKING
  • DRUG-DELIVERY
  • GLYCOL CHITOSAN
  • IN-SITU FORMATION
  • MESENCHYMAL STEM-CELLS
  • PEG HYDROGELS
  • POLYMERIC HYDROGELS
  • SELF-HEALING HYDROGEL
  • STIMULI-RESPONSIVE HYDROGELS
  • cancer eradication
  • injectable hydrogels
  • multiple therapy
  • tissue engineering
  • wound dressing
  • 317 Pharmacy
  • 318 Medical biotechnology

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