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Comorbidity and functional trajectories from midlife to old age: the Health and Retirement Study

  • S. Stenholm
  • , H. Westerlund
  • , J. Head
  • , M. Hyde
  • , I. Kawachi
  • , J. Pentti
  • , Mika Kivimäki
  • , J. Vahtera

Research output: Contribution to journalArticleScientificpeer-review

Abstract

BACKGROUND:

The number of diseases and physical functioning difficulties tend to increase with age. The aim of this study was to examine the trajectories of physical functioning across age groups and whether the trajectories differ according to disease status in different population subgroups.

METHODS:

Repeat data from a nationally representative population sample, the Health and Retirement Study, was used. Participants were 10,709 men and 13,477 women aged 60-107 years at baseline with biennial surveys from 1992 to 2010. Average length of follow-up was 10.3 years ranging from 0 to 18 years. Disease status and physical functioning was asked about at all study phases and 10 items were summed to obtain a physical functioning score (0-10).

RESULTS:

Age modified the relationship between number of chronic diseases and physical functioning with older participants having more physical functioning difficulties with increasing number of diseases. An average 70-year-old participant with no diseases had 0.89 (95% CI: 0.85-0.93) physical functioning difficulties, with one disease 1.72 (95% CI: 1.69-1.76) difficulties, with two diseases 2.57 (95% CI: 2.52-2.62) difficulties, and with three or more diseases 3.82 (95% CI: 3.76-3.88) difficulties. Of the individual diseases memory-related diseases, stroke, pulmonary diseases, and arthritis were associated with significantly higher physical functioning difficulties compared with other diseases.

CONCLUSIONS:

Comorbidity is associated with greater burden of physical functioning difficulties. Of the studied diseases, memory-related diseases, stroke, pulmonary diseases, and arthritis alone or in combination limit most physical functioning.
Original languageEnglish
JournalJournals of Gerontology. Series A: Biological Sciences and Medical Sciences
Volume70
Issue number3
Pages (from-to)332-338
Number of pages7
ISSN1079-5006
DOIs
Publication statusPublished - Mar 2015
Externally publishedYes
MoE publication typeA1 Journal article-refereed

Fields of Science

  • 3142 Public health care science, environmental and occupational health
  • aging
  • comorbidity
  • disability
  • physical functioning

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