Comparison of different vitamin E forms is confounded by heterogeneity in vitamin E effects

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To determine whether RRR α-tocopherol and all-racemic α-tocopherol might differ in their effects on health outcomes, Ranard and Erdman reviewed studies about these 2 forms of vitamin E. They concluded from the published studies that α-tocopherol might be of benefit only to some restricted populations. However, they did not fully discuss the evidence indicating that vitamin E supplementation may also be harmful for certain population groups. In our analyses of the Alpha-Tocopherol, Beta-Carotene (ATBC) Study of Finnish male smokers, we found that vitamin E (dl-α-tocopheryl acetate) had no effect in the majority of subjects. However, vitamin E was beneficial in certain categories of participants and harmful in others. ... At this stage, it does not seem feasible to search for a universal ratio of efficacy of RRR α-tocopherol to all-racemic α-tocopherol. Instead, it would seem more useful first to characterize definitively the population groups for which vitamin E supplementation may be beneficial and only thereafter compare the efficacy of different vitamin E forms in those groups
Original languageEnglish
JournalNutrition Reviews
Issue number9
Pages (from-to)722-723
Number of pages2
Publication statusPublished - 13 Jul 2018
MoE publication typeB1 Journal article

Fields of Science

  • 3142 Public health care science, environmental and occupational health

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