Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles

Karita Haapasalo; Kok van Kessel; Eija Nissilä; Jari Metso; Tiira Johansson; Sini Miettinen; Markku Varjosalo; Juha Kirveskari; Pentti Kuusela; Angelika Chroni; Matti Jauhiainen; Jos van Strijp; T. Sakari Jokiranta

doi:10.1074/jbc.M115.669226

Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles

Karita Haapasalo, Kok van Kessel, Eija Nissilä, Jari Metso, Tiira Johansson, Sini Miettinen, Markku Varjosalo, Juha Kirveskari, Pentti Kuusela, Angelika Chroni, Matti Jauhiainen, Jos van Strijp, T. Sakari Jokiranta

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Journal of Biological Chemistry
Volume	290
Issue number	48
Pages (from-to)	28977-28987
Number of pages	11
ISSN	0021-9258
DOIs	https://doi.org/10.1074/jbc.M115.669226
Publication status	Published - 27 Nov 2015
MoE publication type	A1 Journal article-refereed

Fields of Science

apolipoprotein E (ApoE)
complement
complement system
high density lipoprotein (HDL)
inflammation
factor H
HEMOLYTIC-UREMIC SYNDROME
MACULAR DEGENERATION
MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS
STREPTOCOCCUS-PYOGENES
ALZHEIMERS-DISEASE
PROTEIN BETA-1H
DEPOSIT DISEASE
HUMAN PLASMA
ASSOCIATION
ACTIVATION
3111 Biomedicine

Access to Document

10.1074/jbc.M115.669226

Cite this

Haapasalo, K., van Kessel, K., Nissilä, E., Metso, J., Johansson, T., Miettinen, S., Varjosalo, M., Kirveskari, J., Kuusela, P., Chroni, A., Jauhiainen, M., van Strijp, J., & Jokiranta, T. S. (2015). Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles. Journal of Biological Chemistry, 290(48), 28977-28987. https://doi.org/10.1074/jbc.M115.669226

@article{c117812f76c645cfaeb84885abb685c7,

title = "Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles",

keywords = "apolipoprotein E (ApoE), complement, complement system, high density lipoprotein (HDL), inflammation, factor H, HEMOLYTIC-UREMIC SYNDROME, MACULAR DEGENERATION, MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS, STREPTOCOCCUS-PYOGENES, ALZHEIMERS-DISEASE, PROTEIN BETA-1H, DEPOSIT DISEASE, HUMAN PLASMA, ASSOCIATION, ACTIVATION, 3111 Biomedicine",

author = "Karita Haapasalo and {van Kessel}, Kok and Eija Nissil{\"a} and Jari Metso and Tiira Johansson and Sini Miettinen and Markku Varjosalo and Juha Kirveskari and Pentti Kuusela and Angelika Chroni and Matti Jauhiainen and {van Strijp}, Jos and Jokiranta, {T. Sakari}",

year = "2015",

month = nov,

day = "27",

doi = "10.1074/jbc.M115.669226",

language = "English",

volume = "290",

pages = "28977--28987",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology",

number = "48",

}

Haapasalo, K, van Kessel, K, Nissilä, E, Metso, J, Johansson, T, Miettinen, S, Varjosalo, M, Kirveskari, J, Kuusela, P, Chroni, A, Jauhiainen, M, van Strijp, J & Jokiranta, TS 2015, 'Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles', Journal of Biological Chemistry, vol. 290, no. 48, pp. 28977-28987. https://doi.org/10.1074/jbc.M115.669226

TY - JOUR

T1 - Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles

AU - Haapasalo, Karita

AU - van Kessel, Kok

AU - Nissilä, Eija

AU - Metso, Jari

AU - Johansson, Tiira

AU - Miettinen, Sini

AU - Varjosalo, Markku

AU - Kirveskari, Juha

AU - Kuusela, Pentti

AU - Chroni, Angelika

AU - Jauhiainen, Matti

AU - van Strijp, Jos

AU - Jokiranta, T. Sakari

PY - 2015/11/27

Y1 - 2015/11/27

KW - apolipoprotein E (ApoE)

KW - complement

KW - complement system

KW - high density lipoprotein (HDL)

KW - inflammation

KW - factor H

KW - HEMOLYTIC-UREMIC SYNDROME

KW - MACULAR DEGENERATION

KW - MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS

KW - STREPTOCOCCUS-PYOGENES

KW - ALZHEIMERS-DISEASE

KW - PROTEIN BETA-1H

KW - DEPOSIT DISEASE

KW - HUMAN PLASMA

KW - ASSOCIATION

KW - ACTIVATION

KW - 3111 Biomedicine

U2 - 10.1074/jbc.M115.669226

DO - 10.1074/jbc.M115.669226

M3 - Article

SN - 0021-9258

VL - 290

SP - 28977

EP - 28987

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 48

ER -