Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes

Jèssica Latorre; Francisco J. Ortega; Laura Liñares-Pose; José M. Moreno-Navarrete; Aina Lluch; Ferran Comas; Núria Oliveras-Cañellas; Wifredo Ricart; Marcus Höring; You Zhou; Gerhard Liebisch; P.A. Nidhina Haridas; Vesa M. Olkkonen; Miguel López; José M. Fernández-Real

doi:10.1016/j.ebiom.2020.102697

Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes

Jèssica Latorre, Francisco J. Ortega, Laura Liñares-Pose, José M. Moreno-Navarrete, Aina Lluch, Ferran Comas, Núria Oliveras-Cañellas, Wifredo Ricart, Marcus Höring, You Zhou, Gerhard Liebisch, P.A. Nidhina Haridas, Vesa M. Olkkonen, Miguel López, José M. Fernández-Real

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	102697
Journal	EBioMedicine
Volume	53
Number of pages	16
ISSN	2352-3964
DOIs	https://doi.org/10.1016/j.ebiom.2020.102697
Publication status	Published - Mar 2020
MoE publication type	A1 Journal article-refereed

Fields of Science

3111 Biomedicine
MicroRNAs
AMPK
Hepatocytes
Fatty acid homeostasis
Steatosis
METFORMIN
NAFLD
CHOLESTEROL
DE-NOVO LIPOGENESIS
FATTY LIVER-DISEASE
TRANSCRIPTION
ATHEROSCLEROSIS
METABOLISM
HIGH-THROUGHPUT QUANTIFICATION
MOLECULAR-MECHANISMS

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10.1016/j.ebiom.2020.102697

1-s2.0-S2352396420300724-mainFinal published version, 6.88 MBLicence: CC BY-NC-ND

Cite this

Latorre, J., Ortega, F. J., Liñares-Pose, L., Moreno-Navarrete, J. M., Lluch, A., Comas, F., Oliveras-Cañellas, N., Ricart, W., Höring, M., Zhou, Y., Liebisch, G., Nidhina Haridas, P. A., Olkkonen, V. M., López, M., & Fernández-Real, J. M. (2020). Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes. EBioMedicine, 53, [102697]. https://doi.org/10.1016/j.ebiom.2020.102697

@article{22c1912d3faa487ab115b4c98b0a9712,

title = "Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes",

keywords = "3111 Biomedicine, MicroRNAs, AMPK, Hepatocytes, Fatty acid homeostasis, Steatosis, METFORMIN, NAFLD, CHOLESTEROL, DE-NOVO LIPOGENESIS, FATTY LIVER-DISEASE, TRANSCRIPTION, ATHEROSCLEROSIS, METABOLISM, HIGH-THROUGHPUT QUANTIFICATION, MOLECULAR-MECHANISMS",

author = "J{\`e}ssica Latorre and Ortega, {Francisco J.} and Laura Li{\~n}ares-Pose and Moreno-Navarrete, {Jos{\'e} M.} and Aina Lluch and Ferran Comas and N{\'u}ria Oliveras-Ca{\~n}ellas and Wifredo Ricart and Marcus H{\"o}ring and You Zhou and Gerhard Liebisch and {Nidhina Haridas}, P.A. and Olkkonen, {Vesa M.} and Miguel L{\'o}pez and Fern{\'a}ndez-Real, {Jos{\'e} M.}",

year = "2020",

month = mar,

doi = "10.1016/j.ebiom.2020.102697",

language = "English",

volume = "53",

journal = "EBioMedicine",

issn = "2352-3964",

publisher = "Elsevier Scientific Publ. Co",

}

Latorre, J, Ortega, FJ, Liñares-Pose, L, Moreno-Navarrete, JM, Lluch, A, Comas, F, Oliveras-Cañellas, N, Ricart, W, Höring, M, Zhou, Y, Liebisch, G, Nidhina Haridas, PA, Olkkonen, VM, López, M & Fernández-Real, JM 2020, 'Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes', EBioMedicine, vol. 53, 102697. https://doi.org/10.1016/j.ebiom.2020.102697

TY - JOUR

T1 - Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes

AU - Latorre, Jèssica

AU - Ortega, Francisco J.

AU - Liñares-Pose, Laura

AU - Moreno-Navarrete, José M.

AU - Lluch, Aina

AU - Comas, Ferran

AU - Oliveras-Cañellas, Núria

AU - Ricart, Wifredo

AU - Höring, Marcus

AU - Zhou, You

AU - Liebisch, Gerhard

AU - Nidhina Haridas, P.A.

AU - Olkkonen, Vesa M.

AU - López, Miguel

AU - Fernández-Real, José M.

PY - 2020/3

Y1 - 2020/3

KW - 3111 Biomedicine

KW - MicroRNAs

KW - AMPK

KW - Hepatocytes

KW - Fatty acid homeostasis

KW - Steatosis

KW - METFORMIN

KW - NAFLD

KW - CHOLESTEROL

KW - DE-NOVO LIPOGENESIS

KW - FATTY LIVER-DISEASE

KW - TRANSCRIPTION

KW - ATHEROSCLEROSIS

KW - METABOLISM

KW - HIGH-THROUGHPUT QUANTIFICATION

KW - MOLECULAR-MECHANISMS

U2 - 10.1016/j.ebiom.2020.102697

DO - 10.1016/j.ebiom.2020.102697

M3 - Article

VL - 53

JO - EBioMedicine

JF - EBioMedicine

SN - 2352-3964

M1 - 102697

ER -