Concentrations of medetomidine enantiomers and vatinoxan, an α2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs

Juhana M. Honkavaara; Marja R. Raekallio; Pernilla M. Syrja; Bruno H. Pypendop; Heather K. Knych; Ira J. Kallio-Kujala; Outi M. Vainio

doi:10.1016/j.vaa.2019.07.004

Concentrations of medetomidine enantiomers and vatinoxan, an α₂-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs

Juhana M. Honkavaara, Marja R. Raekallio, Pernilla M. Syrja, Bruno H. Pypendop, Heather K. Knych, Ira J. Kallio-Kujala, Outi M. Vainio

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Veterinary Anaesthesia and Analgesia
Volume	47
Issue number	1
Pages (from-to)	47-52
Number of pages	6
ISSN	1467-2987
DOIs	https://doi.org/10.1016/j.vaa.2019.07.004 https://doi.org/10.1016/j.vaa.2019.07.004
Publication status	Published - Jan 2020
MoE publication type	A1 Journal article-refereed

Fields of Science

413 Veterinary science
central nervous system
distribution
dog
medetomidine
MK-467
vatinoxan
L-659,066
CARDIOPULMONARY
PERIPHERAL ALPHA-2-ADRENOCEPTOR ANTAGONIST
DEXMEDETOMIDINE-INDUCED SEDATION
BRADYCARDIA
RECEPTOR ANTAGONIST
PHARMACOKINETICS
INFUSIONS

Access to Document

1-s2.0-S1467298719302004-mainAccepted author manuscript, 435 KBLicence: CC BY-NC-ND

Cite this

Honkavaara, J. M., Raekallio, M. R., Syrja, P. M., Pypendop, B. H., Knych, H. K., Kallio-Kujala, I. J., & Vainio, O. M. (2020). Concentrations of medetomidine enantiomers and vatinoxan, an α₂-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs. Veterinary Anaesthesia and Analgesia, 47(1), 47-52. https://doi.org/10.1016/j.vaa.2019.07.004, https://doi.org/10.1016/j.vaa.2019.07.004

@article{4942d2b398a64cbbb73456c7f7b3ec33,

title = "Concentrations of medetomidine enantiomers and vatinoxan, an α2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs",

keywords = "413 Veterinary science, central nervous system, distribution, dog, medetomidine, MK-467, vatinoxan, L-659,066, CARDIOPULMONARY, PERIPHERAL ALPHA-2-ADRENOCEPTOR ANTAGONIST, DEXMEDETOMIDINE-INDUCED SEDATION, BRADYCARDIA, RECEPTOR ANTAGONIST, PHARMACOKINETICS, INFUSIONS",

author = "Honkavaara, {Juhana M.} and Raekallio, {Marja R.} and Syrja, {Pernilla M.} and Pypendop, {Bruno H.} and Knych, {Heather K.} and Kallio-Kujala, {Ira J.} and Vainio, {Outi M.}",

year = "2020",

month = jan,

doi = "10.1016/j.vaa.2019.07.004",

language = "English",

volume = "47",

pages = "47--52",

journal = "Veterinary Anaesthesia and Analgesia",

issn = "1467-2987",

publisher = "Elsevier B.V.",

number = "1",

}

Honkavaara, JM , Raekallio, MR , Syrja, PM, Pypendop, BH, Knych, HK, Kallio-Kujala, IJ & Vainio, OM 2020, 'Concentrations of medetomidine enantiomers and vatinoxan, an α₂-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs', Veterinary Anaesthesia and Analgesia, vol. 47, no. 1, pp. 47-52. https://doi.org/10.1016/j.vaa.2019.07.004, https://doi.org/10.1016/j.vaa.2019.07.004

Concentrations of medetomidine enantiomers and vatinoxan, an α₂-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs. / Honkavaara, Juhana M.; Raekallio, Marja R.; Syrja, Pernilla M. et al.
In: Veterinary Anaesthesia and Analgesia, Vol. 47, No. 1, 01.2020, p. 47-52.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Concentrations of medetomidine enantiomers and vatinoxan, an α2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs

AU - Honkavaara, Juhana M.

AU - Raekallio, Marja R.

AU - Syrja, Pernilla M.

AU - Pypendop, Bruno H.

AU - Knych, Heather K.

AU - Kallio-Kujala, Ira J.

AU - Vainio, Outi M.

PY - 2020/1

Y1 - 2020/1

KW - 413 Veterinary science

KW - central nervous system

KW - distribution

KW - dog

KW - medetomidine

KW - MK-467

KW - vatinoxan

KW - L-659,066

KW - CARDIOPULMONARY

KW - PERIPHERAL ALPHA-2-ADRENOCEPTOR ANTAGONIST

KW - DEXMEDETOMIDINE-INDUCED SEDATION

KW - BRADYCARDIA

KW - RECEPTOR ANTAGONIST

KW - PHARMACOKINETICS

KW - INFUSIONS

U2 - 10.1016/j.vaa.2019.07.004

DO - 10.1016/j.vaa.2019.07.004

M3 - Article

SN - 1467-2987

VL - 47

SP - 47

EP - 52

JO - Veterinary Anaesthesia and Analgesia

JF - Veterinary Anaesthesia and Analgesia

IS - 1

ER -

Honkavaara JM , Raekallio MR , Syrja PM, Pypendop BH, Knych HK, Kallio-Kujala IJ et al. Concentrations of medetomidine enantiomers and vatinoxan, an α₂-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs. Veterinary Anaesthesia and Analgesia. 2020 Jan;47(1):47-52. Epub 2019 Aug 29. doi: 10.1016/j.vaa.2019.07.004, 10.1016/j.vaa.2019.07.004