Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke

Thomas Jaworek; Huichun Xu; Brady J. Gaynor; John W. Cole; Kristiina Rannikmae; Tara M. Stanne; Liisa Tomppo; Vida Abedi; Philippe Amouyel; Nicole D. Armstrong; John Attia; Steven Bell; Oscar R. Benavente; Giorgio B. Boncoraglio; Adam Butterworth; Jara Carcel-Marquez; Zhengming Chen; Michael Chong; Carlos Cruchaga; Mary Cushman; John Danesh; Stephanie Debette; David J. Duggan; Jon Peter Durda; Gunnar Engstrom; Chris Enzinger; Jessica D. Faul; Natalie S. Fecteau; Israel Fernandez-Cadenas; Christian Gieger; Anne-Katrin Giese; Raji P. Grewal; Ulrike Grittner; Aki S. Havulinna; Laura Heitsch; Marc C. Hochberg; Elizabeth Holliday; Jie Hu; Andreea Ilinca; Marguerite R. Irvin; Rebecca D. Jackson; Mina A. Jacob; Raquel Rabionet; Jordi Jimenez-Conde; Julie A. Johnson; Yoichiro Kamatani; Sharon L. R. Kardia; Masaru Koido; Michiaki Kubo; Leslie Lange; Jin-Moo Lee; Robin Lemmens; Christopher R. Levi; Jiang Li; Liming Li; Kuang Lin; Haley Lopez; Sothear Luke; Jane Maguire; Patrick F. McArdle; Caitrin W. McDonough; James F. Meschia; Tiina Metso; Martina Mueller-Nurasyid; Timothy D. O'Connor; Martin O'Donnell; Leema R. Peddareddygari; Joanna Pera; James A. Perry; Annette Peters; Jukka Putaala; Debashree Ray; Kathryn Rexrode; Marta Ribases; Jonathan Rosand; Peter M. Rothwell; Tatjana Rundek; Kathleen A. Ryan; Ralph L. Sacco; Veikko Salomaa; Cristina Sanchez-Mora; Reinhold Schmidt; Pankaj Sharma; Agnieszka Slowik; Jennifer A. Smith; Nicholas L. Smith; Sylvia Wassertheil-Smoller; Martin Soderholm; O. Colin Stine; Daniel Strbian; Cathie L. M. Sudlow; Turgut Tatlisumak; Chikashi Terao; Vincent Thijs; Nuria P. Torres-Aguila; David-Alexandre Tregouet; Anil M. Tuladhar; Jan H. Veldink; Robin G. Walters; David R. Weir; Daniel Woo; Bradford B. Worrall; Charles C. Hong; Owen A. Ross; Ramin Zand; Frank-Erik de Leeuw; Arne G. Lindgren; Guillaume Pare; Christopher D. Anderson; Hugh S. Markus; Christina Jern; Rainer Malik; Martin Dichgans; Braxton D. Mitchell; Steven J. Kittner

doi:10.1212/WNL.0000000000201006

Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke

Thomas Jaworek, Huichun Xu, Brady J. Gaynor, John W. Cole, Kristiina Rannikmae, Tara M. Stanne, Liisa Tomppo, Vida Abedi, Philippe Amouyel, Nicole D. Armstrong, John Attia, Steven Bell, Oscar R. Benavente, Giorgio B. Boncoraglio, Adam Butterworth, Jara Carcel-Marquez, Zhengming Chen, Michael Chong, Carlos Cruchaga, Mary CushmanJohn Danesh, Stephanie Debette, David J. Duggan, Jon Peter Durda, Gunnar Engstrom, Chris Enzinger, Jessica D. Faul, Natalie S. Fecteau, Israel Fernandez-Cadenas, Christian Gieger, Anne-Katrin Giese, Raji P. Grewal, Ulrike Grittner, Aki S. Havulinna, Laura Heitsch, Marc C. Hochberg, Elizabeth Holliday, Jie Hu, Andreea Ilinca, Marguerite R. Irvin, Rebecca D. Jackson, Mina A. Jacob, Raquel Rabionet, Jordi Jimenez-Conde, Julie A. Johnson, Yoichiro Kamatani, Sharon L. R. Kardia, Masaru Koido, Michiaki Kubo, Leslie Lange, Jin-Moo Lee, Robin Lemmens, Christopher R. Levi, Jiang Li, Liming Li, Kuang Lin, Haley Lopez, Sothear Luke, Jane Maguire, Patrick F. McArdle, Caitrin W. McDonough, James F. Meschia, Tiina Metso, Martina Mueller-Nurasyid, Timothy D. O'Connor, Martin O'Donnell, Leema R. Peddareddygari, Joanna Pera, James A. Perry, Annette Peters, Jukka Putaala, Debashree Ray, Kathryn Rexrode, Marta Ribases, Jonathan Rosand, Peter M. Rothwell, Tatjana Rundek, Kathleen A. Ryan, Ralph L. Sacco, Veikko Salomaa, Cristina Sanchez-Mora, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Jennifer A. Smith, Nicholas L. Smith, Sylvia Wassertheil-Smoller, Martin Soderholm, O. Colin Stine, Daniel Strbian, Cathie L. M. Sudlow, Turgut Tatlisumak, Chikashi Terao, Vincent Thijs, Nuria P. Torres-Aguila, David-Alexandre Tregouet, Anil M. Tuladhar, Jan H. Veldink, Robin G. Walters, David R. Weir, Daniel Woo, Bradford B. Worrall, Charles C. Hong, Owen A. Ross, Ramin Zand, Frank-Erik de Leeuw, Arne G. Lindgren, Guillaume Pare, Christopher D. Anderson, Hugh S. Markus, Christina Jern, Rainer Malik, Martin Dichgans, Braxton D. Mitchell, Steven J. Kittner

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Neurology
Volume	99
Issue number	16
Pages (from-to)	E1738-E1754
Number of pages	17
ISSN	0028-3878
DOIs	https://doi.org/10.1212/WNL.0000000000201006
Publication status	Published - 18 Oct 2022
MoE publication type	A1 Journal article-refereed

Fields of Science

3112 Neurosciences
3124 Neurology and psychiatry

Access to Document

10.1212/WNL.0000000000201006

BPH_Neurology_2022_JaworekFinal published version, 754 KBLicence: CC BY

Cite this

Jaworek, T., Xu, H., Gaynor, B. J., Cole, J. W., Rannikmae, K., Stanne, T. M., Tomppo, L., Abedi, V., Amouyel, P., Armstrong, N. D., Attia, J., Bell, S., Benavente, O. R., Boncoraglio, G. B., Butterworth, A., Carcel-Marquez, J., Chen, Z., Chong, M., Cruchaga, C., ... Kittner, S. J. (2022). Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke. Neurology, 99(16), E1738-E1754. https://doi.org/10.1212/WNL.0000000000201006

@article{a8d01feca1c940de8be86fec06c876b6,

title = "Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke",

keywords = "Abo blood-group, Genome-wide association, Cardiovascular-disease, Locus, Genotype, 3112 Neurosciences, 3124 Neurology and psychiatry",

author = "Thomas Jaworek and Huichun Xu and Gaynor, {Brady J.} and Cole, {John W.} and Kristiina Rannikmae and Stanne, {Tara M.} and Liisa Tomppo and Vida Abedi and Philippe Amouyel and Armstrong, {Nicole D.} and John Attia and Steven Bell and Benavente, {Oscar R.} and Boncoraglio, {Giorgio B.} and Adam Butterworth and Jara Carcel-Marquez and Zhengming Chen and Michael Chong and Carlos Cruchaga and Mary Cushman and John Danesh and Stephanie Debette and Duggan, {David J.} and Durda, {Jon Peter} and Gunnar Engstrom and Chris Enzinger and Faul, {Jessica D.} and Fecteau, {Natalie S.} and Israel Fernandez-Cadenas and Christian Gieger and Anne-Katrin Giese and Grewal, {Raji P.} and Ulrike Grittner and Havulinna, {Aki S.} and Laura Heitsch and Hochberg, {Marc C.} and Elizabeth Holliday and Jie Hu and Andreea Ilinca and Irvin, {Marguerite R.} and Jackson, {Rebecca D.} and Jacob, {Mina A.} and Raquel Rabionet and Jordi Jimenez-Conde and Johnson, {Julie A.} and Yoichiro Kamatani and Kardia, {Sharon L. R.} and Masaru Koido and Michiaki Kubo and Leslie Lange and Jin-Moo Lee and Robin Lemmens and Levi, {Christopher R.} and Jiang Li and Liming Li and Kuang Lin and Haley Lopez and Sothear Luke and Jane Maguire and McArdle, {Patrick F.} and McDonough, {Caitrin W.} and Meschia, {James F.} and Tiina Metso and Martina Mueller-Nurasyid and O'Connor, {Timothy D.} and Martin O'Donnell and Peddareddygari, {Leema R.} and Joanna Pera and Perry, {James A.} and Annette Peters and Jukka Putaala and Debashree Ray and Kathryn Rexrode and Marta Ribases and Jonathan Rosand and Rothwell, {Peter M.} and Tatjana Rundek and Ryan, {Kathleen A.} and Sacco, {Ralph L.} and Veikko Salomaa and Cristina Sanchez-Mora and Reinhold Schmidt and Pankaj Sharma and Agnieszka Slowik and Smith, {Jennifer A.} and Smith, {Nicholas L.} and Sylvia Wassertheil-Smoller and Martin Soderholm and Stine, {O. Colin} and Daniel Strbian and Sudlow, {Cathie L. M.} and Turgut Tatlisumak and Chikashi Terao and Vincent Thijs and Torres-Aguila, {Nuria P.} and David-Alexandre Tregouet and Tuladhar, {Anil M.} and Veldink, {Jan H.} and Walters, {Robin G.} and Weir, {David R.} and Daniel Woo and Worrall, {Bradford B.} and Hong, {Charles C.} and Ross, {Owen A.} and Ramin Zand and {de Leeuw}, Frank-Erik and Lindgren, {Arne G.} and Guillaume Pare and Anderson, {Christopher D.} and Markus, {Hugh S.} and Christina Jern and Rainer Malik and Martin Dichgans and Mitchell, {Braxton D.} and Kittner, {Steven J.}",

year = "2022",

month = oct,

day = "18",

doi = "10.1212/WNL.0000000000201006",

language = "English",

volume = "99",

pages = "E1738--E1754",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "16",

}

Jaworek, T, Xu, H, Gaynor, BJ, Cole, JW, Rannikmae, K, Stanne, TM, Tomppo, L, Abedi, V, Amouyel, P, Armstrong, ND, Attia, J, Bell, S, Benavente, OR, Boncoraglio, GB, Butterworth, A, Carcel-Marquez, J, Chen, Z, Chong, M, Cruchaga, C, Cushman, M, Danesh, J, Debette, S, Duggan, DJ, Durda, JP, Engstrom, G, Enzinger, C, Faul, JD, Fecteau, NS, Fernandez-Cadenas, I, Gieger, C, Giese, A-K, Grewal, RP, Grittner, U, Havulinna, AS, Heitsch, L, Hochberg, MC, Holliday, E, Hu, J, Ilinca, A, Irvin, MR, Jackson, RD, Jacob, MA, Rabionet, R, Jimenez-Conde, J, Johnson, JA, Kamatani, Y, Kardia, SLR, Koido, M, Kubo, M, Lange, L, Lee, J-M, Lemmens, R, Levi, CR, Li, J, Li, L, Lin, K, Lopez, H, Luke, S, Maguire, J, McArdle, PF, McDonough, CW, Meschia, JF, Metso, T, Mueller-Nurasyid, M, O'Connor, TD, O'Donnell, M, Peddareddygari, LR, Pera, J, Perry, JA, Peters, A, Putaala, J, Ray, D, Rexrode, K, Ribases, M, Rosand, J, Rothwell, PM, Rundek, T, Ryan, KA, Sacco, RL, Salomaa, V, Sanchez-Mora, C, Schmidt, R, Sharma, P, Slowik, A, Smith, JA, Smith, NL, Wassertheil-Smoller, S, Soderholm, M, Stine, OC, Strbian, D, Sudlow, CLM, Tatlisumak, T, Terao, C, Thijs, V, Torres-Aguila, NP, Tregouet, D-A, Tuladhar, AM, Veldink, JH, Walters, RG, Weir, DR, Woo, D, Worrall, BB, Hong, CC, Ross, OA, Zand, R, de Leeuw, F-E, Lindgren, AG, Pare, G, Anderson, CD, Markus, HS, Jern, C, Malik, R, Dichgans, M, Mitchell, BD & Kittner, SJ 2022, 'Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke', Neurology, vol. 99, no. 16, pp. E1738-E1754. https://doi.org/10.1212/WNL.0000000000201006

TY - JOUR

T1 - Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke

AU - Jaworek, Thomas

AU - Xu, Huichun

AU - Gaynor, Brady J.

AU - Cole, John W.

AU - Rannikmae, Kristiina

AU - Stanne, Tara M.

AU - Tomppo, Liisa

AU - Abedi, Vida

AU - Amouyel, Philippe

AU - Armstrong, Nicole D.

AU - Attia, John

AU - Bell, Steven

AU - Benavente, Oscar R.

AU - Boncoraglio, Giorgio B.

AU - Butterworth, Adam

AU - Carcel-Marquez, Jara

AU - Chen, Zhengming

AU - Chong, Michael

AU - Cruchaga, Carlos

AU - Cushman, Mary

AU - Danesh, John

AU - Debette, Stephanie

AU - Duggan, David J.

AU - Durda, Jon Peter

AU - Engstrom, Gunnar

AU - Enzinger, Chris

AU - Faul, Jessica D.

AU - Fecteau, Natalie S.

AU - Fernandez-Cadenas, Israel

AU - Gieger, Christian

AU - Giese, Anne-Katrin

AU - Grewal, Raji P.

AU - Grittner, Ulrike

AU - Havulinna, Aki S.

AU - Heitsch, Laura

AU - Hochberg, Marc C.

AU - Holliday, Elizabeth

AU - Hu, Jie

AU - Ilinca, Andreea

AU - Irvin, Marguerite R.

AU - Jackson, Rebecca D.

AU - Jacob, Mina A.

AU - Rabionet, Raquel

AU - Jimenez-Conde, Jordi

AU - Johnson, Julie A.

AU - Kamatani, Yoichiro

AU - Kardia, Sharon L. R.

AU - Koido, Masaru

AU - Kubo, Michiaki

AU - Lange, Leslie

AU - Lee, Jin-Moo

AU - Lemmens, Robin

AU - Levi, Christopher R.

AU - Li, Jiang

AU - Li, Liming

AU - Lin, Kuang

AU - Lopez, Haley

AU - Luke, Sothear

AU - Maguire, Jane

AU - McArdle, Patrick F.

AU - McDonough, Caitrin W.

AU - Meschia, James F.

AU - Metso, Tiina

AU - Mueller-Nurasyid, Martina

AU - O'Connor, Timothy D.

AU - O'Donnell, Martin

AU - Peddareddygari, Leema R.

AU - Pera, Joanna

AU - Perry, James A.

AU - Peters, Annette

AU - Putaala, Jukka

AU - Ray, Debashree

AU - Rexrode, Kathryn

AU - Ribases, Marta

AU - Rosand, Jonathan

AU - Rothwell, Peter M.

AU - Rundek, Tatjana

AU - Ryan, Kathleen A.

AU - Sacco, Ralph L.

AU - Salomaa, Veikko

AU - Sanchez-Mora, Cristina

AU - Schmidt, Reinhold

AU - Sharma, Pankaj

AU - Slowik, Agnieszka

AU - Smith, Jennifer A.

AU - Smith, Nicholas L.

AU - Wassertheil-Smoller, Sylvia

AU - Soderholm, Martin

AU - Stine, O. Colin

AU - Strbian, Daniel

AU - Sudlow, Cathie L. M.

AU - Tatlisumak, Turgut

AU - Terao, Chikashi

AU - Thijs, Vincent

AU - Torres-Aguila, Nuria P.

AU - Tregouet, David-Alexandre

AU - Tuladhar, Anil M.

AU - Veldink, Jan H.

AU - Walters, Robin G.

AU - Weir, David R.

AU - Woo, Daniel

AU - Worrall, Bradford B.

AU - Hong, Charles C.

AU - Ross, Owen A.

AU - Zand, Ramin

AU - de Leeuw, Frank-Erik

AU - Lindgren, Arne G.

AU - Pare, Guillaume

AU - Anderson, Christopher D.

AU - Markus, Hugh S.

AU - Jern, Christina

AU - Malik, Rainer

AU - Dichgans, Martin

AU - Mitchell, Braxton D.

AU - Kittner, Steven J.

PY - 2022/10/18

Y1 - 2022/10/18

KW - Abo blood-group

KW - Genome-wide association

KW - Cardiovascular-disease

KW - Locus

KW - Genotype

KW - 3112 Neurosciences

KW - 3124 Neurology and psychiatry

U2 - 10.1212/WNL.0000000000201006

DO - 10.1212/WNL.0000000000201006

M3 - Article

C2 - 36240095

SN - 0028-3878

VL - 99

SP - E1738-E1754

JO - Neurology

JF - Neurology

IS - 16

ER -