Contribution of lymphatic‐like vessels to severe neovascularization following stent‐assisted coiling of an unruptured carotid artery aneurysm

Ani M. Korhonen; Edwina A. Brown; Tommi Parkkinen; Sirpa Loukovaara

doi:10.1111/aos.17343

Contribution of lymphatic‐like vessels to severe neovascularization following stent‐assisted coiling of an unruptured carotid artery aneurysm

Ani M. Korhonen, Edwina A. Brown, Tommi Parkkinen, Sirpa Loukovaara

Research output: Conference materials › Abstract › peer-review

Abstract

Aims/Purpose: Intracranial aneurysms (IAs) are a leading cause of hemorrhagic stroke. One method of treatment for unruptured IAs is stent-assisted coil embolization, which can result in complications affecting the eye. These complications can involve severe ischemia of the eyeball, accompanied by neovascularization in both the anterior and posterior segments of the eye, conditions with poorly characterized underlying pathological processes.

We aim to characterize a case where severe neovascular glaucoma (NVG) developed as a complication of a neurosurgical stent-assisted coiling of an internal carotid artery aneurysm. In particular, we investigate potential lymphatic and immune involvement in the vasculature in NVG resulting from complications following neurosurgical coiling of unruptured brain aneurysm.

Methods: Case study of 59-year-old Caucasian female who underwent evisceration of the right eye after complications of elective neurosurgery for coiling of an unruptured anterior communicating artery aneurysm left the eye painful and blind. Patient had developed end-stage neovascular glaucoma, fibrotic retinal detachment, and optic disc neovessel formation in the eye.

We subjected tissues from both the anterior segment (cornea, iris, limbus, lens) and posterior segment (optic nerve head, retinal/detached pathological tissue) of the eviscerated eye to immunohistochemistry.

Results: We identified various cell types and structures in both anterior and posterior segment samples, including immune cells and vascular structures with positivity for lymphatic markers.

Conclusions: There is potential lymphatic and immune involvement in the neovasculature resulting from complications following neurosurgical coiling of unruptured brain aneurysm. The mechanisms governing lymphatic-like differentiation in severe vitreoretinal ischemic eye disorders remain a potential area for further in-depth research.

Volume103, IssueS284

Abstracts from the 2024 European Association for Vision and Eye Research Congress, 3‐5 November 2024, Valencia

January 2025

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Original language	English
DOIs	https://doi.org/10.1111/aos.17343
Publication status	Published - 19 Jan 2025
MoE publication type	Not Eligible
Event	2024 European Association for Vision and Eye Research Congress - Valencia, Spain Duration: 3 Nov 2024 → 5 Nov 2024

Conference

Conference	2024 European Association for Vision and Eye Research Congress
Country/Territory	Spain
City	Valencia
Period	03/11/2024 → 05/11/2024

Fields of Science

Intracranial Aneurysms

Access to Document

10.1111/aos.17343

Cite this

@conference{a7eeecb34f5847168a836d8d16e8162a,

title = "Contribution of lymphatic‐like vessels to severe neovascularization following stent‐assisted coiling of an unruptured carotid artery aneurysm",

abstract = " Aims/Purpose: Intracranial aneurysms (IAs) are a leading cause of hemorrhagic stroke. One method of treatment for unruptured IAs is stent-assisted coil embolization, which can result in complications affecting the eye. These complications can involve severe ischemia of the eyeball, accompanied by neovascularization in both the anterior and posterior segments of the eye, conditions with poorly characterized underlying pathological processes. We aim to characterize a case where severe neovascular glaucoma (NVG) developed as a complication of a neurosurgical stent-assisted coiling of an internal carotid artery aneurysm. In particular, we investigate potential lymphatic and immune involvement in the vasculature in NVG resulting from complications following neurosurgical coiling of unruptured brain aneurysm. Methods: Case study of 59-year-old Caucasian female who underwent evisceration of the right eye after complications of elective neurosurgery for coiling of an unruptured anterior communicating artery aneurysm left the eye painful and blind. Patient had developed end-stage neovascular glaucoma, fibrotic retinal detachment, and optic disc neovessel formation in the eye. We subjected tissues from both the anterior segment (cornea, iris, limbus, lens) and posterior segment (optic nerve head, retinal/detached pathological tissue) of the eviscerated eye to immunohistochemistry. Results: We identified various cell types and structures in both anterior and posterior segment samples, including immune cells and vascular structures with positivity for lymphatic markers. Conclusions: There is potential lymphatic and immune involvement in the neovasculature resulting from complications following neurosurgical coiling of unruptured brain aneurysm. The mechanisms governing lymphatic-like differentiation in severe vitreoretinal ischemic eye disorders remain a potential area for further in-depth research. Volume103, IssueS284 Abstracts from the 2024 European Association for Vision and Eye Research Congress, 3‐5 November 2024, Valencia January 2025 Related Information Recommended Glaucoma after ipsilateral carotid artery stent placement Sang-Mi Noh Geriatrics \& Gerontology International NEOVASCULAR GLAUCOMA ASSOCIATED WITH OCULAR HYPOPERFUSION SECONDARY TO CAROTID ARTERY DISEASE RALPH A. HIGGINS FRACO FRACS Australian Journal of Opthalmology Antegrade Internal Carotid Artery Collateral Flow and Cerebral Blood Flow in Patients With Common Carotid Artery Occlusion Asako Nakamura MD, Yoshiyuki Wakugawa MD, Masahiro Yasaka MD, Toshiyasu Ogata MD, Kotaro Yasumori MD, Takanari Kitazono MD, Yasushi Okada MD Journal of Ultrasound in Medicine Preliminary clinical analysis of neovascular glaucoma secondary to carotid artery disease Biye Zhou MD, Ping Ye MD, Shihui Wei MD Clinical and Experimental Optometry ",

keywords = "Intracranial Aneurysms, Intracranial Aneurysms, Intracranial Aneurysms",

author = "Korhonen, \{Ani M.\} and Brown, \{Edwina A.\} and Tommi Parkkinen and Sirpa Loukovaara",

year = "2025",

month = jan,

day = "19",

doi = "10.1111/aos.17343",

language = "English",

note = "2024 European Association for Vision and Eye Research Congress ; Conference date: 03-11-2024 Through 05-11-2024",

}

Contribution of lymphatic‐like vessels to severe neovascularization following stent‐assisted coiling of an unruptured carotid artery aneurysm. / Korhonen, Ani M.; Brown, Edwina A.; Parkkinen, Tommi et al.
2025. Abstract from 2024 European Association for Vision and Eye Research Congress, Valencia, Spain.

Research output: Conference materials › Abstract › peer-review

TY - CONF

T1 - Contribution of lymphatic‐like vessels to severe neovascularization following stent‐assisted coiling of an unruptured carotid artery aneurysm

AU - Korhonen, Ani M.

AU - Brown, Edwina A.

AU - Parkkinen, Tommi

AU - Loukovaara, Sirpa

PY - 2025/1/19

Y1 - 2025/1/19

N2 - Aims/Purpose: Intracranial aneurysms (IAs) are a leading cause of hemorrhagic stroke. One method of treatment for unruptured IAs is stent-assisted coil embolization, which can result in complications affecting the eye. These complications can involve severe ischemia of the eyeball, accompanied by neovascularization in both the anterior and posterior segments of the eye, conditions with poorly characterized underlying pathological processes. We aim to characterize a case where severe neovascular glaucoma (NVG) developed as a complication of a neurosurgical stent-assisted coiling of an internal carotid artery aneurysm. In particular, we investigate potential lymphatic and immune involvement in the vasculature in NVG resulting from complications following neurosurgical coiling of unruptured brain aneurysm. Methods: Case study of 59-year-old Caucasian female who underwent evisceration of the right eye after complications of elective neurosurgery for coiling of an unruptured anterior communicating artery aneurysm left the eye painful and blind. Patient had developed end-stage neovascular glaucoma, fibrotic retinal detachment, and optic disc neovessel formation in the eye. We subjected tissues from both the anterior segment (cornea, iris, limbus, lens) and posterior segment (optic nerve head, retinal/detached pathological tissue) of the eviscerated eye to immunohistochemistry. Results: We identified various cell types and structures in both anterior and posterior segment samples, including immune cells and vascular structures with positivity for lymphatic markers. Conclusions: There is potential lymphatic and immune involvement in the neovasculature resulting from complications following neurosurgical coiling of unruptured brain aneurysm. The mechanisms governing lymphatic-like differentiation in severe vitreoretinal ischemic eye disorders remain a potential area for further in-depth research. Volume103, IssueS284 Abstracts from the 2024 European Association for Vision and Eye Research Congress, 3‐5 November 2024, Valencia January 2025 Related Information Recommended Glaucoma after ipsilateral carotid artery stent placement Sang-Mi Noh Geriatrics & Gerontology International NEOVASCULAR GLAUCOMA ASSOCIATED WITH OCULAR HYPOPERFUSION SECONDARY TO CAROTID ARTERY DISEASE RALPH A. HIGGINS FRACO FRACS Australian Journal of Opthalmology Antegrade Internal Carotid Artery Collateral Flow and Cerebral Blood Flow in Patients With Common Carotid Artery Occlusion Asako Nakamura MD, Yoshiyuki Wakugawa MD, Masahiro Yasaka MD, Toshiyasu Ogata MD, Kotaro Yasumori MD, Takanari Kitazono MD, Yasushi Okada MD Journal of Ultrasound in Medicine Preliminary clinical analysis of neovascular glaucoma secondary to carotid artery disease Biye Zhou MD, Ping Ye MD, Shihui Wei MD Clinical and Experimental Optometry

AB - Aims/Purpose: Intracranial aneurysms (IAs) are a leading cause of hemorrhagic stroke. One method of treatment for unruptured IAs is stent-assisted coil embolization, which can result in complications affecting the eye. These complications can involve severe ischemia of the eyeball, accompanied by neovascularization in both the anterior and posterior segments of the eye, conditions with poorly characterized underlying pathological processes. We aim to characterize a case where severe neovascular glaucoma (NVG) developed as a complication of a neurosurgical stent-assisted coiling of an internal carotid artery aneurysm. In particular, we investigate potential lymphatic and immune involvement in the vasculature in NVG resulting from complications following neurosurgical coiling of unruptured brain aneurysm. Methods: Case study of 59-year-old Caucasian female who underwent evisceration of the right eye after complications of elective neurosurgery for coiling of an unruptured anterior communicating artery aneurysm left the eye painful and blind. Patient had developed end-stage neovascular glaucoma, fibrotic retinal detachment, and optic disc neovessel formation in the eye. We subjected tissues from both the anterior segment (cornea, iris, limbus, lens) and posterior segment (optic nerve head, retinal/detached pathological tissue) of the eviscerated eye to immunohistochemistry. Results: We identified various cell types and structures in both anterior and posterior segment samples, including immune cells and vascular structures with positivity for lymphatic markers. Conclusions: There is potential lymphatic and immune involvement in the neovasculature resulting from complications following neurosurgical coiling of unruptured brain aneurysm. The mechanisms governing lymphatic-like differentiation in severe vitreoretinal ischemic eye disorders remain a potential area for further in-depth research. Volume103, IssueS284 Abstracts from the 2024 European Association for Vision and Eye Research Congress, 3‐5 November 2024, Valencia January 2025 Related Information Recommended Glaucoma after ipsilateral carotid artery stent placement Sang-Mi Noh Geriatrics & Gerontology International NEOVASCULAR GLAUCOMA ASSOCIATED WITH OCULAR HYPOPERFUSION SECONDARY TO CAROTID ARTERY DISEASE RALPH A. HIGGINS FRACO FRACS Australian Journal of Opthalmology Antegrade Internal Carotid Artery Collateral Flow and Cerebral Blood Flow in Patients With Common Carotid Artery Occlusion Asako Nakamura MD, Yoshiyuki Wakugawa MD, Masahiro Yasaka MD, Toshiyasu Ogata MD, Kotaro Yasumori MD, Takanari Kitazono MD, Yasushi Okada MD Journal of Ultrasound in Medicine Preliminary clinical analysis of neovascular glaucoma secondary to carotid artery disease Biye Zhou MD, Ping Ye MD, Shihui Wei MD Clinical and Experimental Optometry

KW - Intracranial Aneurysms

U2 - 10.1111/aos.17343

DO - 10.1111/aos.17343

M3 - Abstract

T2 - 2024 European Association for Vision and Eye Research Congress

Y2 - 3 November 2024 through 5 November 2024

ER -