Copolymers: Drug Delivery (Book Chapter)

Kobra Rostamizadeh, Mohammad-Ali Shahbazi, Mehrdad Hamidi, Hélder A. Santos

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Abstract

Advances in the pharmaceutical field to develop novel drug delivery systems are increasing rapidly and contributing to improved drug safety and efficacy via modifications in the physicochemical properties of the drug of interest, which eventually leads to improved pharmacokinetic profiles. One important class of materials that has opened new avenues to overcome some of the limitations of the conventional drug dosage forms are copolymers. Copolymer materials comprise at least two structurally different monomers linked together in different arrangements via covalent bonds. As a consequence of the inherent variations in hydrophilicity, solubility, and other physicochemical properties of different polymeric blocks, copolymers are able to form several types of structures, mainly including micelles, polymersomes, and hydrogels. In this entry, we highlight some of the basic principles and developments of copolymers applications as therapeutic delivery systems, particularly the most common methods of synthesis of copolymers, the micellar-shaped copolymers, polymersomes, and hydrogels, while pointing out the most relevant references in the field. Finally, we will conclude with an overview of the potential of copolymers in the future of drug delivery.
Original languageEnglish
Title of host publicationEncyclopedia of Biomedical Polymers and Polymeric Biomaterials
EditorsM. Mishra
Number of pages11
PublisherCRC Press, Taylor & Francis Group
Publication date4 Dec 2015
Edition1st
Pages2192-2202
ISBN (Electronic)1-4398-9879-0
Publication statusPublished - 4 Dec 2015
MoE publication typeA3 Book chapter

Fields of Science

  • 317 Pharmacy

Cite this

Rostamizadeh, K., Shahbazi, M-A., Hamidi, M., & Santos, H. A. (2015). Copolymers: Drug Delivery (Book Chapter). In M. Mishra (Ed.), Encyclopedia of Biomedical Polymers and Polymeric Biomaterials (1st ed., pp. 2192-2202). CRC Press, Taylor & Francis Group.
Rostamizadeh, Kobra ; Shahbazi, Mohammad-Ali ; Hamidi, Mehrdad ; Santos, Hélder A. / Copolymers: Drug Delivery (Book Chapter). Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. editor / M. Mishra. 1st. ed. CRC Press, Taylor & Francis Group, 2015. pp. 2192-2202
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Rostamizadeh, K, Shahbazi, M-A, Hamidi, M & Santos, HA 2015, Copolymers: Drug Delivery (Book Chapter). in M Mishra (ed.), Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. 1st edn, CRC Press, Taylor & Francis Group, pp. 2192-2202.

Copolymers: Drug Delivery (Book Chapter). / Rostamizadeh, Kobra ; Shahbazi, Mohammad-Ali; Hamidi, Mehrdad ; Santos, Hélder A.

Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. ed. / M. Mishra. 1st. ed. CRC Press, Taylor & Francis Group, 2015. p. 2192-2202.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

TY - CHAP

T1 - Copolymers: Drug Delivery (Book Chapter)

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AU - Shahbazi, Mohammad-Ali

AU - Hamidi, Mehrdad

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Y1 - 2015/12/4

N2 - Advances in the pharmaceutical field to develop novel drug delivery systems are increasing rapidly and contributing to improved drug safety and efficacy via modifications in the physicochemical properties of the drug of interest, which eventually leads to improved pharmacokinetic profiles. One important class of materials that has opened new avenues to overcome some of the limitations of the conventional drug dosage forms are copolymers. Copolymer materials comprise at least two structurally different monomers linked together in different arrangements via covalent bonds. As a consequence of the inherent variations in hydrophilicity, solubility, and other physicochemical properties of different polymeric blocks, copolymers are able to form several types of structures, mainly including micelles, polymersomes, and hydrogels. In this entry, we highlight some of the basic principles and developments of copolymers applications as therapeutic delivery systems, particularly the most common methods of synthesis of copolymers, the micellar-shaped copolymers, polymersomes, and hydrogels, while pointing out the most relevant references in the field. Finally, we will conclude with an overview of the potential of copolymers in the future of drug delivery.

AB - Advances in the pharmaceutical field to develop novel drug delivery systems are increasing rapidly and contributing to improved drug safety and efficacy via modifications in the physicochemical properties of the drug of interest, which eventually leads to improved pharmacokinetic profiles. One important class of materials that has opened new avenues to overcome some of the limitations of the conventional drug dosage forms are copolymers. Copolymer materials comprise at least two structurally different monomers linked together in different arrangements via covalent bonds. As a consequence of the inherent variations in hydrophilicity, solubility, and other physicochemical properties of different polymeric blocks, copolymers are able to form several types of structures, mainly including micelles, polymersomes, and hydrogels. In this entry, we highlight some of the basic principles and developments of copolymers applications as therapeutic delivery systems, particularly the most common methods of synthesis of copolymers, the micellar-shaped copolymers, polymersomes, and hydrogels, while pointing out the most relevant references in the field. Finally, we will conclude with an overview of the potential of copolymers in the future of drug delivery.

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M3 - Chapter

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EP - 2202

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Rostamizadeh K, Shahbazi M-A, Hamidi M, Santos HA. Copolymers: Drug Delivery (Book Chapter). In Mishra M, editor, Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. 1st ed. CRC Press, Taylor & Francis Group. 2015. p. 2192-2202