Copper-Free Click Chemistry Modification of Nanovectors For Integrin Targeted Cancer Therapy (Book Chapter)

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Abstract

Strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry is the chemical reaction between azide and cyclooctyne groups. This reaction can conjugate biological molecules, such as peptides, in a highly selective way under mild conditions without cross-reaction with the most widely existing reactive groups, such as amine, carboxylic acid, and hydroxide. Thus, the SPAAC reaction is very versatile for biomolecules conjugation. In this book chapter, we provide detailed protocols of conjugation of integrin targeting peptides to either amine or carboxylic acid terminated porous silicon nanovectors by SPAAC, which can be used to enhance the cellular uptake for intracellular cancer drug delivery and for in vivo cancer theranostics.
Original languageEnglish
Title of host publicationIntegrin Targeting Systems for Tumor Diagnosis and Therapy
EditorsEleonora Patsenker
Number of pages15
Place of PublicationNew York
PublisherSpringer Science+Business Media
Publication date2018
Pages35-49
ISBN (Print)978-1-4939-7443-6
ISBN (Electronic)978-1-4939-7445-0
DOIs
Publication statusPublished - 2018
MoE publication typeA3 Book chapter

Publication series

Name Methods in Pharmacology and Toxicology
ISSN (Print)1557-2153
ISSN (Electronic)1940-6053

Fields of Science

  • 317 Pharmacy
  • Multiple organ diseases
  • Structural analysis
  • Biomarkers
  • Drug delivery
  • Cancer research
  • Integrin imaging

Cite this

Wang, C-F., & Santos, H. A. (2018). Copper-Free Click Chemistry Modification of Nanovectors For Integrin Targeted Cancer Therapy (Book Chapter). In E. Patsenker (Ed.), Integrin Targeting Systems for Tumor Diagnosis and Therapy (pp. 35-49). ( Methods in Pharmacology and Toxicology). New York: Springer Science+Business Media. https://doi.org/10.1007/7653_2015_44
Wang, Chang-Fang ; Santos, Hélder A. / Copper-Free Click Chemistry Modification of Nanovectors For Integrin Targeted Cancer Therapy (Book Chapter). Integrin Targeting Systems for Tumor Diagnosis and Therapy. editor / Eleonora Patsenker. New York : Springer Science+Business Media, 2018. pp. 35-49 ( Methods in Pharmacology and Toxicology).
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abstract = "Strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry is the chemical reaction between azide and cyclooctyne groups. This reaction can conjugate biological molecules, such as peptides, in a highly selective way under mild conditions without cross-reaction with the most widely existing reactive groups, such as amine, carboxylic acid, and hydroxide. Thus, the SPAAC reaction is very versatile for biomolecules conjugation. In this book chapter, we provide detailed protocols of conjugation of integrin targeting peptides to either amine or carboxylic acid terminated porous silicon nanovectors by SPAAC, which can be used to enhance the cellular uptake for intracellular cancer drug delivery and for in vivo cancer theranostics.",
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Wang, C-F & Santos, HA 2018, Copper-Free Click Chemistry Modification of Nanovectors For Integrin Targeted Cancer Therapy (Book Chapter). in E Patsenker (ed.), Integrin Targeting Systems for Tumor Diagnosis and Therapy. Methods in Pharmacology and Toxicology, Springer Science+Business Media, New York, pp. 35-49. https://doi.org/10.1007/7653_2015_44

Copper-Free Click Chemistry Modification of Nanovectors For Integrin Targeted Cancer Therapy (Book Chapter). / Wang, Chang-Fang; Santos, Hélder A.

Integrin Targeting Systems for Tumor Diagnosis and Therapy. ed. / Eleonora Patsenker. New York : Springer Science+Business Media, 2018. p. 35-49 ( Methods in Pharmacology and Toxicology).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

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AB - Strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry is the chemical reaction between azide and cyclooctyne groups. This reaction can conjugate biological molecules, such as peptides, in a highly selective way under mild conditions without cross-reaction with the most widely existing reactive groups, such as amine, carboxylic acid, and hydroxide. Thus, the SPAAC reaction is very versatile for biomolecules conjugation. In this book chapter, we provide detailed protocols of conjugation of integrin targeting peptides to either amine or carboxylic acid terminated porous silicon nanovectors by SPAAC, which can be used to enhance the cellular uptake for intracellular cancer drug delivery and for in vivo cancer theranostics.

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KW - Multiple organ diseases

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Wang C-F, Santos HA. Copper-Free Click Chemistry Modification of Nanovectors For Integrin Targeted Cancer Therapy (Book Chapter). In Patsenker E, editor, Integrin Targeting Systems for Tumor Diagnosis and Therapy. New York: Springer Science+Business Media. 2018. p. 35-49. ( Methods in Pharmacology and Toxicology). https://doi.org/10.1007/7653_2015_44