Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8

Helinä Kahma; Anne M. Filppula; Terhi Launiainen; Jenni Viinamäki; Mikko Neuvonen; Eric A. Evangelista; Rheem A. Totah; Janne T. Backman

doi:10.1124/dmd.118.085498

Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8

Helinä Kahma, Anne M. Filppula, Terhi Launiainen, Jenni Viinamäki, Mikko Neuvonen, Eric A. Evangelista, Rheem A. Totah, Janne T. Backman

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Drug Metabolism and Disposition
Volume	47
Issue number	4
Pages (from-to)	436-443
Number of pages	8
ISSN	0090-9556
DOIs	https://doi.org/10.1124/dmd.118.085498
Publication status	Published - 1 Apr 2019
MoE publication type	A1 Journal article-refereed

Fields of Science

HUMAN LIVER-MICROSOMES
INCREASES PLASMA-CONCENTRATIONS
CYTOCHROME-P450 ENZYMES
MARKEDLY INCREASES
MASS-SPECTROMETRY
GEMFIBROZIL
GLUCURONIDATION
INHIBITION
CLOPIDOGREL
METABOLISM
317 Pharmacy
3111 Biomedicine

Access to Document

10.1124/dmd.118.085498

Cite this

@article{f89e7818086e46fc9606c89928c852ce,

title = "Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8",

keywords = "HUMAN LIVER-MICROSOMES, INCREASES PLASMA-CONCENTRATIONS, CYTOCHROME-P450 ENZYMES, MARKEDLY INCREASES, MASS-SPECTROMETRY, GEMFIBROZIL, GLUCURONIDATION, INHIBITION, CLOPIDOGREL, METABOLISM, 317 Pharmacy, 3111 Biomedicine",

author = "Helin{\"a} Kahma and Filppula, {Anne M.} and Terhi Launiainen and Jenni Viinam{\"a}ki and Mikko Neuvonen and Evangelista, {Eric A.} and Totah, {Rheem A.} and Backman, {Janne T.}",

year = "2019",

month = apr,

day = "1",

doi = "10.1124/dmd.118.085498",

language = "English",

volume = "47",

pages = "436--443",

journal = "Drug Metabolism and Disposition",

issn = "1521-009X",

publisher = "American Society for Pharmacology and Experimental Therapeutics",

number = "4",

}

Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8. / Kahma, Helinä ; Filppula, Anne M.; Launiainen, Terhi; Viinamäki, Jenni; Neuvonen, Mikko; Evangelista, Eric A.; Totah, Rheem A.; Backman, Janne T.

In: Drug Metabolism and Disposition, Vol. 47, No. 4, 01.04.2019, p. 436-443.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8

AU - Kahma, Helinä

AU - Filppula, Anne M.

AU - Launiainen, Terhi

AU - Viinamäki, Jenni

AU - Neuvonen, Mikko

AU - Evangelista, Eric A.

AU - Totah, Rheem A.

AU - Backman, Janne T.

PY - 2019/4/1

Y1 - 2019/4/1

KW - HUMAN LIVER-MICROSOMES

KW - INCREASES PLASMA-CONCENTRATIONS

KW - CYTOCHROME-P450 ENZYMES

KW - MARKEDLY INCREASES

KW - MASS-SPECTROMETRY

KW - GEMFIBROZIL

KW - GLUCURONIDATION

KW - INHIBITION

KW - CLOPIDOGREL

KW - METABOLISM

KW - 317 Pharmacy

KW - 3111 Biomedicine

U2 - 10.1124/dmd.118.085498

DO - 10.1124/dmd.118.085498

M3 - Article

VL - 47

SP - 436

EP - 443

JO - Drug Metabolism and Disposition

JF - Drug Metabolism and Disposition

SN - 1521-009X

IS - 4

ER -