Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8

Helinä Kahma, Anne M. Filppula, Terhi Launiainen, Jenni Viinamäki, Mikko Neuvonen, Eric A. Evangelista, Rheem A. Totah, Janne T. Backman

Research output: Contribution to journal › Article › Scientific › peer-review

Original languageEnglish
JournalDrug Metabolism and Disposition
Volume47
Issue number4
Pages (from-to)436-443
Number of pages8
ISSN0090-9556
DOIs
Publication statusPublished - 1 Apr 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • HUMAN LIVER-MICROSOMES
  • INCREASES PLASMA-CONCENTRATIONS
  • CYTOCHROME-P450 ENZYMES
  • MARKEDLY INCREASES
  • MASS-SPECTROMETRY
  • GEMFIBROZIL
  • GLUCURONIDATION
  • INHIBITION
  • CLOPIDOGREL
  • METABOLISM
  • 317 Pharmacy
  • 3111 Biomedicine

Cite this

Kahma, Helinä ; Filppula, Anne M. ; Launiainen, Terhi ; Viinamäki, Jenni ; Neuvonen, Mikko ; Evangelista, Eric A. ; Totah, Rheem A. ; Backman, Janne T. / Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8. In: Drug Metabolism and Disposition. 2019 ; Vol. 47, No. 4. pp. 436-443.
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title = "Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8",
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author = "Helin{\"a} Kahma and Filppula, {Anne M.} and Terhi Launiainen and Jenni Viinam{\"a}ki and Mikko Neuvonen and Evangelista, {Eric A.} and Totah, {Rheem A.} and Backman, {Janne T.}",
year = "2019",
month = "4",
day = "1",
doi = "10.1124/dmd.118.085498",
language = "English",
volume = "47",
pages = "436--443",
journal = "Drug Metabolism and Disposition",
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publisher = "American Society for Pharmacology and Experimental Therapeutics",
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}

Kahma, H, Filppula, AM, Launiainen, T, Viinamäki, J, Neuvonen, M, Evangelista, EA, Totah, RA & Backman, JT 2019, 'Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8' Drug Metabolism and Disposition, vol. 47, no. 4, pp. 436-443. https://doi.org/10.1124/dmd.118.085498

Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8. / Kahma, Helinä; Filppula, Anne M.; Launiainen, Terhi; Viinamäki, Jenni; Neuvonen, Mikko; Evangelista, Eric A.; Totah, Rheem A.; Backman, Janne T.

In: Drug Metabolism and Disposition, Vol. 47, No. 4, 01.04.2019, p. 436-443.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8

AU - Kahma, Helinä

AU - Filppula, Anne M.

AU - Launiainen, Terhi

AU - Viinamäki, Jenni

AU - Neuvonen, Mikko

AU - Evangelista, Eric A.

AU - Totah, Rheem A.

AU - Backman, Janne T.

PY - 2019/4/1

Y1 - 2019/4/1

KW - HUMAN LIVER-MICROSOMES

KW - INCREASES PLASMA-CONCENTRATIONS

KW - CYTOCHROME-P450 ENZYMES

KW - MARKEDLY INCREASES

KW - MASS-SPECTROMETRY

KW - GEMFIBROZIL

KW - GLUCURONIDATION

KW - INHIBITION

KW - CLOPIDOGREL

KW - METABOLISM

KW - 317 Pharmacy

KW - 3111 Biomedicine

U2 - 10.1124/dmd.118.085498

DO - 10.1124/dmd.118.085498

M3 - Article

VL - 47

SP - 436

EP - 443

JO - Drug Metabolism and Disposition

JF - Drug Metabolism and Disposition

SN - 1521-009X

IS - 4

ER -

Kahma H, Filppula AM, Launiainen T, Viinamäki J, Neuvonen M, Evangelista EA et al. Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8. Drug Metabolism and Disposition. 2019 Apr 1;47(4):436-443. https://doi.org/10.1124/dmd.118.085498

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