Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1

Rajesh K. Harijan; Tiila-Riikka Kiema; Shahan M. Syed; Imran Qadir; Muriel Mazet; Frederic Bringaud; Paul A. M. Michels; Rik K. Wierenga

doi:10.1093/protein/gzw080

Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1

Rajesh K. Harijan, Tiila-Riikka Kiema, Shahan M. Syed, Imran Qadir, Muriel Mazet, Frederic Bringaud, Paul A. M. Michels, Rik K. Wierenga

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Protein Engineering, Design and Selection
Volume	30
Issue number	3
Pages (from-to)	227-235
Number of pages	9
ISSN	1741-0126
DOIs	https://doi.org/10.1093/protein/gzw080
Publication status	Published - Mar 2017
Externally published	Yes
MoE publication type	A1 Journal article-refereed

Fields of Science

Coenzyme A
crystal structure
Leishmania mexicana
leishmaniasis
ligand binding
lipid metabolism
SCP2-thiolase
sleeping sickness
Trypanosoma brucei
beta-oxidation
PEROXISOMAL 3-KETOACYL-COA THIOLASE
CRYSTAL-STRUCTURE
BIOCHEMICAL-CHARACTERIZATION
CLOSTRIDIUM-ACETOBUTYLICUM
SACCHAROMYCES-CEREVISIAE
SPECIFICITIES
SUPERFAMILY
MECHANISM
1182 Biochemistry, cell and molecular biology

Access to Document

10.1093/protein/gzw080

Cite this

@article{7cb09bec3f924b24affd4ef20b936ffc,

title = "Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1",

keywords = "Coenzyme A, crystal structure, Leishmania mexicana, leishmaniasis, ligand binding, lipid metabolism, SCP2-thiolase, sleeping sickness, Trypanosoma brucei, beta-oxidation, PEROXISOMAL 3-KETOACYL-COA THIOLASE, CRYSTAL-STRUCTURE, BIOCHEMICAL-CHARACTERIZATION, CLOSTRIDIUM-ACETOBUTYLICUM, SACCHAROMYCES-CEREVISIAE, SPECIFICITIES, SUPERFAMILY, MECHANISM, 1182 Biochemistry, cell and molecular biology",

author = "Harijan, {Rajesh K.} and Tiila-Riikka Kiema and Syed, {Shahan M.} and Imran Qadir and Muriel Mazet and Frederic Bringaud and Michels, {Paul A. M.} and Wierenga, {Rik K.}",

year = "2017",

month = mar,

doi = "10.1093/protein/gzw080",

language = "English",

volume = "30",

pages = "227--235",

journal = "Protein Engineering, Design and Selection",

issn = "1741-0126",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2)

T2 - unique features of oxyanion hole-1

AU - Harijan, Rajesh K.

AU - Kiema, Tiila-Riikka

AU - Syed, Shahan M.

AU - Qadir, Imran

AU - Mazet, Muriel

AU - Bringaud, Frederic

AU - Michels, Paul A. M.

AU - Wierenga, Rik K.

PY - 2017/3

Y1 - 2017/3

KW - Coenzyme A

KW - crystal structure

KW - Leishmania mexicana

KW - leishmaniasis

KW - ligand binding

KW - lipid metabolism

KW - SCP2-thiolase

KW - sleeping sickness

KW - Trypanosoma brucei

KW - beta-oxidation

KW - PEROXISOMAL 3-KETOACYL-COA THIOLASE

KW - CRYSTAL-STRUCTURE

KW - BIOCHEMICAL-CHARACTERIZATION

KW - CLOSTRIDIUM-ACETOBUTYLICUM

KW - SACCHAROMYCES-CEREVISIAE

KW - SPECIFICITIES

KW - SUPERFAMILY

KW - MECHANISM

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.1093/protein/gzw080

DO - 10.1093/protein/gzw080

M3 - Article

VL - 30

SP - 227

EP - 235

JO - Protein Engineering, Design and Selection

JF - Protein Engineering, Design and Selection

SN - 1741-0126

IS - 3

ER -