Cycle changing the medium results in increased nisin productivity per cell in Lactococcus lactis

Oemer Simsek, Per E. J. Saris

Research output: Contribution to journalArticleScientificpeer-review

Abstract

High specific cellular nisin production was aimed by cycle changing the medium of Lactococcus lactis N8 and LAC48. The highest level of nisin production was reached with the 120 min cycles but maximal production was unstable. In shorter cycles (30 and 60 min) cells could be maintained in a high production state up to the end of the fermentation (28 and 14 cycles). N8 produced 19-fold and LAC48 15-fold more nisin with cycle changing the medium than without cycle incubation.
Original languageEnglish
JournalBiotechnology Letters
Volume31
Issue number3
Pages (from-to)415-421
Number of pages7
ISSN0141-5492
DOIs
Publication statusPublished - 2009
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Cycle changing medium
  • Feedback inhibition
  • Lactococcus lactis
  • Nisin production
  • SUPPLEMENTED WHEY PERMEATE
  • CULTURES
  • BATCH
  • UL719
  • AERATION
  • 118 Biological sciences

Cite this

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keywords = "Cycle changing medium, Feedback inhibition, Lactococcus lactis, Nisin production, SUPPLEMENTED WHEY PERMEATE, CULTURES, BATCH, UL719, AERATION, 118 Biological sciences",
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Cycle changing the medium results in increased nisin productivity per cell in Lactococcus lactis. / Simsek, Oemer; Saris, Per E. J.

In: Biotechnology Letters, Vol. 31, No. 3, 2009, p. 415-421.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Cycle changing the medium results in increased nisin productivity per cell in Lactococcus lactis

AU - Simsek, Oemer

AU - Saris, Per E. J.

PY - 2009

Y1 - 2009

N2 - High specific cellular nisin production was aimed by cycle changing the medium of Lactococcus lactis N8 and LAC48. The highest level of nisin production was reached with the 120 min cycles but maximal production was unstable. In shorter cycles (30 and 60 min) cells could be maintained in a high production state up to the end of the fermentation (28 and 14 cycles). N8 produced 19-fold and LAC48 15-fold more nisin with cycle changing the medium than without cycle incubation.

AB - High specific cellular nisin production was aimed by cycle changing the medium of Lactococcus lactis N8 and LAC48. The highest level of nisin production was reached with the 120 min cycles but maximal production was unstable. In shorter cycles (30 and 60 min) cells could be maintained in a high production state up to the end of the fermentation (28 and 14 cycles). N8 produced 19-fold and LAC48 15-fold more nisin with cycle changing the medium than without cycle incubation.

KW - Cycle changing medium

KW - Feedback inhibition

KW - Lactococcus lactis

KW - Nisin production

KW - SUPPLEMENTED WHEY PERMEATE

KW - CULTURES

KW - BATCH

KW - UL719

KW - AERATION

KW - 118 Biological sciences

U2 - 10.1007/s10529-008-9891-2

DO - 10.1007/s10529-008-9891-2

M3 - Article

VL - 31

SP - 415

EP - 421

JO - Biotechnology Letters

JF - Biotechnology Letters

SN - 0141-5492

IS - 3

ER -