CYP3A4*22 Impairs the Elimination of Ticagrelor, But Has No Significant Effect on the Bioactivation of Clopidogrel or Prasugrel

Mikko T. Holmberg, Aleksi Tornio, Maria Paile-Hyvärinen, E. Katriina Tarkiainen, Mikko Neuvonen, Pertti J. Neuvonen, Janne T. Backman, Mikko Niemi

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalClinical Pharmacology and Therapeutics
Volume105
Issue number2
Pages (from-to)448-457
Number of pages10
ISSN0009-9236
DOIs
Publication statusPublished - Feb 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • SINGLE NUCLEOTIDE POLYMORPHISM
  • GRAPEFRUIT JUICE
  • GENETIC POLYMORPHISMS
  • PHARMACOKINETICS
  • CYP3A4
  • PHARMACODYNAMICS
  • INHIBITORS
  • OUTCOMES
  • CYP2C19
  • DETERMINANTS
  • 317 Pharmacy
  • 3111 Biomedicine

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