Dedifferentiation of Primary Hepatocytes is Accompanied with Reorganization of Lipid Metabolism Indicated by Altered Molecular Lipid and miRNA Profiles

Mostafa Kiamehr, Laura Heiskanen, Thomas Laufer, Aneta Duesterloh, Mustafa Kahraman, Reijo Kakela, Reijo Laaksonen, Katriina Aalto-Setala

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
Article number2910
JournalInternational Journal of Molecular Sciences
Volume20
Issue number12
Number of pages20
ISSN1422-0067
DOIs
Publication statusPublished - 2 Jun 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • primary human hepatocytes (PHHs)
  • dedifferentiation
  • lipidomics
  • mass spectrometry
  • sphingolipids (SLs)
  • phospholipids (PLs)
  • saturated fatty acids (SFAs)
  • monounsaturated fatty acids (MUFAs)
  • polyunsaturated fatty acids (PUFAs)
  • microRNAs (miRNAs)
  • CERAMIDE SYNTHASES
  • SPHINGOLIPID METABOLISM
  • GLUCOSE-METABOLISM
  • HIGH-THROUGHPUT
  • RECEPTOR-ALPHA
  • HEPG2 CELLS
  • IN-VITRO
  • LIVER
  • EXPRESSION
  • MICRORNAS
  • 1182 Biochemistry, cell and molecular biology

Cite this

@article{3307491f80954d379f51cdbd1f4d7afd,
title = "Dedifferentiation of Primary Hepatocytes is Accompanied with Reorganization of Lipid Metabolism Indicated by Altered Molecular Lipid and miRNA Profiles",
keywords = "primary human hepatocytes (PHHs), dedifferentiation, lipidomics, mass spectrometry, sphingolipids (SLs), phospholipids (PLs), saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), microRNAs (miRNAs), CERAMIDE SYNTHASES, SPHINGOLIPID METABOLISM, GLUCOSE-METABOLISM, HIGH-THROUGHPUT, RECEPTOR-ALPHA, HEPG2 CELLS, IN-VITRO, LIVER, EXPRESSION, MICRORNAS, 1182 Biochemistry, cell and molecular biology",
author = "Mostafa Kiamehr and Laura Heiskanen and Thomas Laufer and Aneta Duesterloh and Mustafa Kahraman and Reijo Kakela and Reijo Laaksonen and Katriina Aalto-Setala",
year = "2019",
month = "6",
day = "2",
doi = "10.3390/ijms20122910",
language = "English",
volume = "20",
journal = "International Journal of Molecular Sciences",
issn = "1422-0067",
publisher = "MDPI",
number = "12",

}

Dedifferentiation of Primary Hepatocytes is Accompanied with Reorganization of Lipid Metabolism Indicated by Altered Molecular Lipid and miRNA Profiles. / Kiamehr, Mostafa; Heiskanen, Laura; Laufer, Thomas; Duesterloh, Aneta; Kahraman, Mustafa; Kakela, Reijo; Laaksonen, Reijo; Aalto-Setala, Katriina.

In: International Journal of Molecular Sciences, Vol. 20, No. 12, 2910, 02.06.2019.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Dedifferentiation of Primary Hepatocytes is Accompanied with Reorganization of Lipid Metabolism Indicated by Altered Molecular Lipid and miRNA Profiles

AU - Kiamehr, Mostafa

AU - Heiskanen, Laura

AU - Laufer, Thomas

AU - Duesterloh, Aneta

AU - Kahraman, Mustafa

AU - Kakela, Reijo

AU - Laaksonen, Reijo

AU - Aalto-Setala, Katriina

PY - 2019/6/2

Y1 - 2019/6/2

KW - primary human hepatocytes (PHHs)

KW - dedifferentiation

KW - lipidomics

KW - mass spectrometry

KW - sphingolipids (SLs)

KW - phospholipids (PLs)

KW - saturated fatty acids (SFAs)

KW - monounsaturated fatty acids (MUFAs)

KW - polyunsaturated fatty acids (PUFAs)

KW - microRNAs (miRNAs)

KW - CERAMIDE SYNTHASES

KW - SPHINGOLIPID METABOLISM

KW - GLUCOSE-METABOLISM

KW - HIGH-THROUGHPUT

KW - RECEPTOR-ALPHA

KW - HEPG2 CELLS

KW - IN-VITRO

KW - LIVER

KW - EXPRESSION

KW - MICRORNAS

KW - 1182 Biochemistry, cell and molecular biology

U2 - 10.3390/ijms20122910

DO - 10.3390/ijms20122910

M3 - Article

VL - 20

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 12

M1 - 2910

ER -