Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias

Riikka H. Hämäläinen, Juan C. Landoni, Kati J. Ahlqvist, Steffi Goffart, Sanna Ryytty, M. Obaidur Rahman, Virginia Brilhante, Katherine Icay, Sampsa Hautaniemi, Liya Wang, Marikki Laiho, Anu Suomalainen

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalNature metabolism
Volume1
Issue number10
Pages (from-to)958-+
Number of pages13
DOIs
Publication statusPublished - Oct 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • MITOCHONDRIAL-DNA MUTATIONS
  • OXIDATIVE STRESS
  • COPY NUMBER
  • PHENOTYPES
  • MICE
  • HALLMARKS
  • IMPACT
  • DAMAGE
  • ATM
  • 3111 Biomedicine
  • 3121 Internal medicine

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