Dehydroabietylamine-Based Cellulose Nanofibril Films: A New Class of Sustainable Biomaterials for Highly Efficient, Broad-Spectrum Antimicrobial Effects

Ghada Ali Mohamed Saber Hassan, Nina Forsman, Xing Wan, Leena Keurulainen, Luis M. Bimbo, Leena-Sisko Johansson, Nina Sipari, Jari Tapani Yli-Kauhaluoma, Ralf Zimmermann, Susanne Stehl, Carsten Werner, Per E. J. Saris, Monika Österberg, Vânia M. Moreira

Research output: Contribution to journalArticleScientificpeer-review

Abstract

The design of antimicrobial surfaces as integral parts of advanced biomaterials is nowadays a high research priority, as the accumulation of microorganisms on surfaces inflicts substantial costs on the health and industry sectors. At present, there is a growing interest in designing functional materials from polymers abundant in nature, such as cellulose, that combine sustainability with outstanding mechanical properties and economic production. There is also the need to find suitable replacements for antimicrobial silver-based agents due to environmental toxicity and spread of resistance to metal antimicrobials. Herein we report the unprecedented decoration of cellulose nanofibril (CNF) films with dehydroabietylamine 1 (CNF-CMC-1), to give an innovative contact-active surface active against Gram-positive and Gram-negative bacteria including the methicillin-resistant S. aureus MRSA14TK301, with low potential to spread resistance and good biocompatibility, all achieved with low surface coverage. CNF-CMC-1 was particularly effective against S. aureus ATCC12528, causing virtually complete reduction of the total cells from 10(5) colony forming units (CFU)/mL bacterial suspensions, after 24 h of contact. This gentle chemical modification of the surface of CNF fully retained the beneficial properties of the original film, including moisture buffering and strength, relevant in many potential applications. Our originally designed surface represents a new class of ecofriendly biomaterials that optimizes the performance of CNF by adding antimicrobial properties without the need for environmentally toxic silver.

Original languageEnglish
JournalACS Sustainable Chemistry & Engineering
Volume7
Issue number5
Pages (from-to)5002-5009
Number of pages8
ISSN2168-0485
DOIs
Publication statusPublished - 4 Mar 2019
MoE publication typeA1 Journal article-refereed

Fields of Science

  • Antimicrobial
  • BACTERIA
  • Biomaterials
  • CARBOXYMETHYL CELLULOSE
  • COATINGS
  • Dehydroabietylamine
  • Drug-resistant
  • NANOCELLULOSE
  • Nanocellulose
  • SILVER NANOPARTICLES
  • SURFACES
  • Silver
  • 116 Chemical sciences
  • 317 Pharmacy

Cite this

@article{1cd163c7e17149a9a22a10b09dabd858,
title = "Dehydroabietylamine-Based Cellulose Nanofibril Films: A New Class of Sustainable Biomaterials for Highly Efficient, Broad-Spectrum Antimicrobial Effects",
abstract = "The design of antimicrobial surfaces as integral parts of advanced biomaterials is nowadays a high research priority, as the accumulation of microorganisms on surfaces inflicts substantial costs on the health and industry sectors. At present, there is a growing interest in designing functional materials from polymers abundant in nature, such as cellulose, that combine sustainability with outstanding mechanical properties and economic production. There is also the need to find suitable replacements for antimicrobial silver-based agents due to environmental toxicity and spread of resistance to metal antimicrobials. Herein we report the unprecedented decoration of cellulose nanofibril (CNF) films with dehydroabietylamine 1 (CNF-CMC-1), to give an innovative contact-active surface active against Gram-positive and Gram-negative bacteria including the methicillin-resistant S. aureus MRSA14TK301, with low potential to spread resistance and good biocompatibility, all achieved with low surface coverage. CNF-CMC-1 was particularly effective against S. aureus ATCC12528, causing virtually complete reduction of the total cells from 10(5) colony forming units (CFU)/mL bacterial suspensions, after 24 h of contact. This gentle chemical modification of the surface of CNF fully retained the beneficial properties of the original film, including moisture buffering and strength, relevant in many potential applications. Our originally designed surface represents a new class of ecofriendly biomaterials that optimizes the performance of CNF by adding antimicrobial properties without the need for environmentally toxic silver.",
keywords = "Antimicrobial, BACTERIA, Biomaterials, CARBOXYMETHYL CELLULOSE, COATINGS, Dehydroabietylamine, Drug-resistant, NANOCELLULOSE, Nanocellulose, SILVER NANOPARTICLES, SURFACES, Silver, 116 Chemical sciences, 317 Pharmacy",
author = "Hassan, {Ghada Ali Mohamed Saber} and Nina Forsman and Xing Wan and Leena Keurulainen and Bimbo, {Luis M.} and Leena-Sisko Johansson and Nina Sipari and Yli-Kauhaluoma, {Jari Tapani} and Ralf Zimmermann and Susanne Stehl and Carsten Werner and Saris, {Per E. J.} and Monika {\"O}sterberg and Moreira, {V{\^a}nia M.}",
year = "2019",
month = "3",
day = "4",
doi = "10.1021/acssuschemeng.8b05658",
language = "English",
volume = "7",
pages = "5002--5009",
journal = "ACS Sustainable Chemistry & Engineering",
issn = "2168-0485",
publisher = "American Chemical Society",
number = "5",

}

Dehydroabietylamine-Based Cellulose Nanofibril Films : A New Class of Sustainable Biomaterials for Highly Efficient, Broad-Spectrum Antimicrobial Effects. / Hassan, Ghada Ali Mohamed Saber; Forsman, Nina ; Wan, Xing; Keurulainen, Leena ; Bimbo, Luis M.; Johansson, Leena-Sisko; Sipari, Nina ; Yli-Kauhaluoma, Jari Tapani; Zimmermann, Ralf; Stehl, Susanne; Werner, Carsten; Saris, Per E. J.; Österberg, Monika; Moreira, Vânia M.

In: ACS Sustainable Chemistry & Engineering, Vol. 7, No. 5, 04.03.2019, p. 5002-5009.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Dehydroabietylamine-Based Cellulose Nanofibril Films

T2 - A New Class of Sustainable Biomaterials for Highly Efficient, Broad-Spectrum Antimicrobial Effects

AU - Hassan, Ghada Ali Mohamed Saber

AU - Forsman, Nina

AU - Wan, Xing

AU - Keurulainen, Leena

AU - Bimbo, Luis M.

AU - Johansson, Leena-Sisko

AU - Sipari, Nina

AU - Yli-Kauhaluoma, Jari Tapani

AU - Zimmermann, Ralf

AU - Stehl, Susanne

AU - Werner, Carsten

AU - Saris, Per E. J.

AU - Österberg, Monika

AU - Moreira, Vânia M.

PY - 2019/3/4

Y1 - 2019/3/4

N2 - The design of antimicrobial surfaces as integral parts of advanced biomaterials is nowadays a high research priority, as the accumulation of microorganisms on surfaces inflicts substantial costs on the health and industry sectors. At present, there is a growing interest in designing functional materials from polymers abundant in nature, such as cellulose, that combine sustainability with outstanding mechanical properties and economic production. There is also the need to find suitable replacements for antimicrobial silver-based agents due to environmental toxicity and spread of resistance to metal antimicrobials. Herein we report the unprecedented decoration of cellulose nanofibril (CNF) films with dehydroabietylamine 1 (CNF-CMC-1), to give an innovative contact-active surface active against Gram-positive and Gram-negative bacteria including the methicillin-resistant S. aureus MRSA14TK301, with low potential to spread resistance and good biocompatibility, all achieved with low surface coverage. CNF-CMC-1 was particularly effective against S. aureus ATCC12528, causing virtually complete reduction of the total cells from 10(5) colony forming units (CFU)/mL bacterial suspensions, after 24 h of contact. This gentle chemical modification of the surface of CNF fully retained the beneficial properties of the original film, including moisture buffering and strength, relevant in many potential applications. Our originally designed surface represents a new class of ecofriendly biomaterials that optimizes the performance of CNF by adding antimicrobial properties without the need for environmentally toxic silver.

AB - The design of antimicrobial surfaces as integral parts of advanced biomaterials is nowadays a high research priority, as the accumulation of microorganisms on surfaces inflicts substantial costs on the health and industry sectors. At present, there is a growing interest in designing functional materials from polymers abundant in nature, such as cellulose, that combine sustainability with outstanding mechanical properties and economic production. There is also the need to find suitable replacements for antimicrobial silver-based agents due to environmental toxicity and spread of resistance to metal antimicrobials. Herein we report the unprecedented decoration of cellulose nanofibril (CNF) films with dehydroabietylamine 1 (CNF-CMC-1), to give an innovative contact-active surface active against Gram-positive and Gram-negative bacteria including the methicillin-resistant S. aureus MRSA14TK301, with low potential to spread resistance and good biocompatibility, all achieved with low surface coverage. CNF-CMC-1 was particularly effective against S. aureus ATCC12528, causing virtually complete reduction of the total cells from 10(5) colony forming units (CFU)/mL bacterial suspensions, after 24 h of contact. This gentle chemical modification of the surface of CNF fully retained the beneficial properties of the original film, including moisture buffering and strength, relevant in many potential applications. Our originally designed surface represents a new class of ecofriendly biomaterials that optimizes the performance of CNF by adding antimicrobial properties without the need for environmentally toxic silver.

KW - Antimicrobial

KW - BACTERIA

KW - Biomaterials

KW - CARBOXYMETHYL CELLULOSE

KW - COATINGS

KW - Dehydroabietylamine

KW - Drug-resistant

KW - NANOCELLULOSE

KW - Nanocellulose

KW - SILVER NANOPARTICLES

KW - SURFACES

KW - Silver

KW - 116 Chemical sciences

KW - 317 Pharmacy

U2 - 10.1021/acssuschemeng.8b05658

DO - 10.1021/acssuschemeng.8b05658

M3 - Article

VL - 7

SP - 5002

EP - 5009

JO - ACS Sustainable Chemistry & Engineering

JF - ACS Sustainable Chemistry & Engineering

SN - 2168-0485

IS - 5

ER -