Depression-executive dysfunction syndrome in stroke patients

    Research output: Contribution to journalArticleScientificpeer-review

    Abstract

    Objective: It has been suggested that executive dysfunction could be the core defect in patients with geriatric or vascular depression, and that this depression-dysexecutive syndrome (DES) might be related to frontal-subcortical circuit dysfunction. The authors tested this hypothesis in 158 poststroke patients, of whom 21 had both depression and executive dysfunction. Methods: In this cross-sectional cohort study, a neurological, psychiatric, and neuropsychological examination was carried out 3 months after ischemic stroke, and brain infarcts, white-matter changes, and brain atrophy were recorded by MRI. Results: The 21 patients with DES had significantly more brain infarcts affecting their frontal-subcortical circuit structures than the 137 patients without DES, or the 41 patients with depression but without executive dysfunction. Patients with DES also had more severe depressive symptoms and worse psychosocial functioning, and they coped less well in complex activities of daily living. Conclusions: DES is a valid concept and may define a subgroup of poststroke patients with frontal-subcortical pathology and with distinct prognosis and treatment options.
    Original languageEnglish
    JournalAmerican Journal of Geriatric Psychiatry
    Volume13
    Issue number2
    Pages (from-to)99-107
    Number of pages9
    ISSN1064-7481
    Publication statusPublished - 2005
    MoE publication typeA1 Journal article-refereed

    Fields of Science

    • 515 Psychology
    • 312 Clinical medicine

    Cite this

    @article{c39318fd40134bf2920b2ab884cabb72,
    title = "Depression-executive dysfunction syndrome in stroke patients",
    abstract = "Objective: It has been suggested that executive dysfunction could be the core defect in patients with geriatric or vascular depression, and that this depression-dysexecutive syndrome (DES) might be related to frontal-subcortical circuit dysfunction. The authors tested this hypothesis in 158 poststroke patients, of whom 21 had both depression and executive dysfunction. Methods: In this cross-sectional cohort study, a neurological, psychiatric, and neuropsychological examination was carried out 3 months after ischemic stroke, and brain infarcts, white-matter changes, and brain atrophy were recorded by MRI. Results: The 21 patients with DES had significantly more brain infarcts affecting their frontal-subcortical circuit structures than the 137 patients without DES, or the 41 patients with depression but without executive dysfunction. Patients with DES also had more severe depressive symptoms and worse psychosocial functioning, and they coped less well in complex activities of daily living. Conclusions: DES is a valid concept and may define a subgroup of poststroke patients with frontal-subcortical pathology and with distinct prognosis and treatment options.",
    keywords = "515 Psychology, 312 Clinical medicine",
    author = "Risto Vataja and Tarja Pohjasvaara and Riitta M{\"a}ntyl{\"a} and Raija Ylikoski and Maarit Leskel{\"a} and Hely Kalska and Marja Hietanen and Aronen, {Hannu J} and Oili Salonen and Markku Kaste and Antero Lepp{\"a}vuori and Timo Erkinjuntti",
    year = "2005",
    language = "English",
    volume = "13",
    pages = "99--107",
    journal = "American Journal of Geriatric Psychiatry",
    issn = "1064-7481",
    publisher = "LIPPINCOTT WILLIAMS & WILKINS",
    number = "2",

    }

    Depression-executive dysfunction syndrome in stroke patients. / Vataja, Risto; Pohjasvaara, Tarja; Mäntylä, Riitta; Ylikoski, Raija; Leskelä, Maarit; Kalska, Hely; Hietanen, Marja; Aronen, Hannu J; Salonen, Oili; Kaste, Markku; Leppävuori, Antero; Erkinjuntti, Timo.

    In: American Journal of Geriatric Psychiatry, Vol. 13, No. 2, 2005, p. 99-107.

    Research output: Contribution to journalArticleScientificpeer-review

    TY - JOUR

    T1 - Depression-executive dysfunction syndrome in stroke patients

    AU - Vataja, Risto

    AU - Pohjasvaara, Tarja

    AU - Mäntylä, Riitta

    AU - Ylikoski, Raija

    AU - Leskelä, Maarit

    AU - Kalska, Hely

    AU - Hietanen, Marja

    AU - Aronen, Hannu J

    AU - Salonen, Oili

    AU - Kaste, Markku

    AU - Leppävuori, Antero

    AU - Erkinjuntti, Timo

    PY - 2005

    Y1 - 2005

    N2 - Objective: It has been suggested that executive dysfunction could be the core defect in patients with geriatric or vascular depression, and that this depression-dysexecutive syndrome (DES) might be related to frontal-subcortical circuit dysfunction. The authors tested this hypothesis in 158 poststroke patients, of whom 21 had both depression and executive dysfunction. Methods: In this cross-sectional cohort study, a neurological, psychiatric, and neuropsychological examination was carried out 3 months after ischemic stroke, and brain infarcts, white-matter changes, and brain atrophy were recorded by MRI. Results: The 21 patients with DES had significantly more brain infarcts affecting their frontal-subcortical circuit structures than the 137 patients without DES, or the 41 patients with depression but without executive dysfunction. Patients with DES also had more severe depressive symptoms and worse psychosocial functioning, and they coped less well in complex activities of daily living. Conclusions: DES is a valid concept and may define a subgroup of poststroke patients with frontal-subcortical pathology and with distinct prognosis and treatment options.

    AB - Objective: It has been suggested that executive dysfunction could be the core defect in patients with geriatric or vascular depression, and that this depression-dysexecutive syndrome (DES) might be related to frontal-subcortical circuit dysfunction. The authors tested this hypothesis in 158 poststroke patients, of whom 21 had both depression and executive dysfunction. Methods: In this cross-sectional cohort study, a neurological, psychiatric, and neuropsychological examination was carried out 3 months after ischemic stroke, and brain infarcts, white-matter changes, and brain atrophy were recorded by MRI. Results: The 21 patients with DES had significantly more brain infarcts affecting their frontal-subcortical circuit structures than the 137 patients without DES, or the 41 patients with depression but without executive dysfunction. Patients with DES also had more severe depressive symptoms and worse psychosocial functioning, and they coped less well in complex activities of daily living. Conclusions: DES is a valid concept and may define a subgroup of poststroke patients with frontal-subcortical pathology and with distinct prognosis and treatment options.

    KW - 515 Psychology

    KW - 312 Clinical medicine

    M3 - Article

    VL - 13

    SP - 99

    EP - 107

    JO - American Journal of Geriatric Psychiatry

    JF - American Journal of Geriatric Psychiatry

    SN - 1064-7481

    IS - 2

    ER -