Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion

T. A. Tervonen; D. Belitskin; S. M. Pant; J. I. Englund; E. Marques; H. Ala-Hongisto; L. Nevalaita; H. Sihto; P. Heikkila; M. Leidenius; K. Hewitson; M. Ramachandra; A. Moilanen; H. Joensuu; P. E. Kovanen; A. Poso; J. Klefstrom

doi:10.1038/onc.2015.248

Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion

T. A. Tervonen, D. Belitskin, S. M. Pant, J. I. Englund, E. Marques, H. Ala-Hongisto, L. Nevalaita, H. Sihto, P. Heikkila, M. Leidenius, K. Hewitson, M. Ramachandra, A. Moilanen, H. Joensuu, P. E. Kovanen, A. Poso, J. Klefstrom

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Journal	Oncogene
Volume	35
Issue number	14
Pages (from-to)	1832-1846
Number of pages	15
ISSN	0950-9232
DOIs	https://doi.org/10.1038/onc.2015.248
Publication status	Published - 7 Apr 2016
MoE publication type	A1 Journal article-refereed

Fields of Science

HEPATOCYTE GROWTH-FACTOR
FACTOR ACTIVATOR INHIBITOR-1
PROSTATE-CANCER PROGRESSION
BREAST-CANCER
MATRIPTASE-ACTIVATION
MOUSE MODEL
IN-VITRO
IDENTIFICATION
SUBSTRATE
CELLS
3111 Biomedicine

Access to Document

10.1038/onc.2015.248

Cite this

Tervonen, T. A., Belitskin, D., Pant, S. M., Englund, J. I., Marques, E., Ala-Hongisto, H., Nevalaita, L., Sihto, H., Heikkila, P., Leidenius, M., Hewitson, K., Ramachandra, M., Moilanen, A., Joensuu, H., Kovanen, P. E., Poso, A., & Klefstrom, J. (2016). Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion. Oncogene, 35(14), 1832-1846. https://doi.org/10.1038/onc.2015.248

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author = "Tervonen, {T. A.} and D. Belitskin and Pant, {S. M.} and Englund, {J. I.} and E. Marques and H. Ala-Hongisto and L. Nevalaita and H. Sihto and P. Heikkila and M. Leidenius and K. Hewitson and M. Ramachandra and A. Moilanen and H. Joensuu and Kovanen, {P. E.} and A. Poso and J. Klefstrom",

year = "2016",

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Tervonen, TA, Belitskin, D, Pant, SM, Englund, JI, Marques, E, Ala-Hongisto, H, Nevalaita, L, Sihto, H , Heikkila, P , Leidenius, M, Hewitson, K, Ramachandra, M, Moilanen, A, Joensuu, H , Kovanen, PE, Poso, A & Klefstrom, J 2016, 'Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion', Oncogene, vol. 35, no. 14, pp. 1832-1846. https://doi.org/10.1038/onc.2015.248

TY - JOUR

T1 - Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion

AU - Tervonen, T. A.

AU - Belitskin, D.

AU - Pant, S. M.

AU - Englund, J. I.

AU - Marques, E.

AU - Ala-Hongisto, H.

AU - Nevalaita, L.

AU - Sihto, H.

AU - Heikkila, P.

AU - Leidenius, M.

AU - Hewitson, K.

AU - Ramachandra, M.

AU - Moilanen, A.

AU - Joensuu, H.

AU - Kovanen, P. E.

AU - Poso, A.

AU - Klefstrom, J.

PY - 2016/4/7

Y1 - 2016/4/7

KW - HEPATOCYTE GROWTH-FACTOR

KW - FACTOR ACTIVATOR INHIBITOR-1

KW - PROSTATE-CANCER PROGRESSION

KW - BREAST-CANCER

KW - MATRIPTASE-ACTIVATION

KW - MOUSE MODEL

KW - IN-VITRO

KW - IDENTIFICATION

KW - SUBSTRATE

KW - CELLS

KW - 3111 Biomedicine

U2 - 10.1038/onc.2015.248

DO - 10.1038/onc.2015.248

M3 - Article

VL - 35

SP - 1832

EP - 1846

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 14

ER -