Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform

Shishir M. Pant, Amanda Mukonoweshuro, Bimbisar Desai, Manoj K. Ramjee, Christopher N. Selway, Gary J. Tarver, Adrian G. Wright, Kristian Birchall, Timothy M. Chapman, Topi A. Tervonen, Juha Klefström

Research output: Contribution to journalArticleScientificpeer-review

Original languageEnglish
JournalJournal of Medicinal Chemistry
Volume61
Issue number10
Pages (from-to)4335-4347
Number of pages13
ISSN0022-2623
DOIs
Publication statusPublished - 24 May 2018
MoE publication typeA1 Journal article-refereed

Fields of Science

  • HEPATOCYTE GROWTH-FACTOR
  • PROTEASE ACTIVITY
  • PROSTATE-CANCER
  • KINASE INHIBITORS
  • OVARIAN-CANCER
  • TRYPSIN
  • METASTASIS
  • DISCOVERY
  • THROMBIN
  • MET
  • 3111 Biomedicine

Cite this

Pant, Shishir M. ; Mukonoweshuro, Amanda ; Desai, Bimbisar ; Ramjee, Manoj K. ; Selway, Christopher N. ; Tarver, Gary J. ; Wright, Adrian G. ; Birchall, Kristian ; Chapman, Timothy M. ; Tervonen, Topi A. ; Klefström, Juha. / Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform. In: Journal of Medicinal Chemistry. 2018 ; Vol. 61, No. 10. pp. 4335-4347.
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title = "Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform",
keywords = "HEPATOCYTE GROWTH-FACTOR, PROTEASE ACTIVITY, PROSTATE-CANCER, KINASE INHIBITORS, OVARIAN-CANCER, TRYPSIN, METASTASIS, DISCOVERY, THROMBIN, MET, 3111 Biomedicine",
author = "Pant, {Shishir M.} and Amanda Mukonoweshuro and Bimbisar Desai and Ramjee, {Manoj K.} and Selway, {Christopher N.} and Tarver, {Gary J.} and Wright, {Adrian G.} and Kristian Birchall and Chapman, {Timothy M.} and Tervonen, {Topi A.} and Juha Klefstr{\"o}m",
year = "2018",
month = "5",
day = "24",
doi = "10.1021/acs.jmedchem.7601698",
language = "English",
volume = "61",
pages = "4335--4347",
journal = "Journal of Medicinal Chemistry",
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publisher = "American Chemical Society",
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}

Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform. / Pant, Shishir M.; Mukonoweshuro, Amanda; Desai, Bimbisar; Ramjee, Manoj K.; Selway, Christopher N.; Tarver, Gary J.; Wright, Adrian G.; Birchall, Kristian; Chapman, Timothy M.; Tervonen, Topi A.; Klefström, Juha.

In: Journal of Medicinal Chemistry, Vol. 61, No. 10, 24.05.2018, p. 4335-4347.

Research output: Contribution to journalArticleScientificpeer-review

TY - JOUR

T1 - Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform

AU - Pant, Shishir M.

AU - Mukonoweshuro, Amanda

AU - Desai, Bimbisar

AU - Ramjee, Manoj K.

AU - Selway, Christopher N.

AU - Tarver, Gary J.

AU - Wright, Adrian G.

AU - Birchall, Kristian

AU - Chapman, Timothy M.

AU - Tervonen, Topi A.

AU - Klefström, Juha

PY - 2018/5/24

Y1 - 2018/5/24

KW - HEPATOCYTE GROWTH-FACTOR

KW - PROTEASE ACTIVITY

KW - PROSTATE-CANCER

KW - KINASE INHIBITORS

KW - OVARIAN-CANCER

KW - TRYPSIN

KW - METASTASIS

KW - DISCOVERY

KW - THROMBIN

KW - MET

KW - 3111 Biomedicine

U2 - 10.1021/acs.jmedchem.7601698

DO - 10.1021/acs.jmedchem.7601698

M3 - Article

VL - 61

SP - 4335

EP - 4347

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 10

ER -