Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting

James H. A. Clubb; Tatiana V. Kudling; Mykhailo Girych; Lyna Haybout; Santeri Pakola; Firas Hamdan; Victor Cervera-Carrascon; Annabrita Hemmes; Susanna Grönberg-Vähä-Koskela; Joao Manuel Santos; Dafne C. A. Quixabeira; Saru Basnet; Camilla Heiniö; Victor Arias; Elise Jirovec; Shreyas Kaptan; Riikka Havunen; Suvi Sorsa; Abdullah Erikat; Joel Schwartz; Marjukka Anttila; Katri Aro; Tapani Viitala; Ilpo Vattulainen; Vincenzo Cerullo; Anna Kanerva; Akseli Hemminki

doi:10.3389/fimmu.2023.1060540

Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting

James H. A. Clubb, Tatiana V. Kudling, Mykhailo Girych, Lyna Haybout, Santeri Pakola, Firas Hamdan, Victor Cervera-Carrascon, Annabrita Hemmes, Susanna Grönberg-Vähä-Koskela, Joao Manuel Santos, Dafne C. A. Quixabeira, Saru Basnet, Camilla Heiniö, Victor Arias, Elise Jirovec, Shreyas Kaptan, Riikka Havunen, Suvi Sorsa, Abdullah Erikat, Joel SchwartzMarjukka Anttila, Katri Aro, Tapani Viitala, Ilpo Vattulainen, Vincenzo Cerullo, Anna Kanerva, Akseli Hemminki

Research output: Contribution to journal › Article › Scientific › peer-review

Original language	English
Article number	1060540
Journal	Frontiers in Immunology
Volume	14
Number of pages	20
ISSN	1664-3224
DOIs	https://doi.org/10.3389/fimmu.2023.1060540
Publication status	Published - 3 Feb 2023
MoE publication type	A1 Journal article-refereed

Fields of Science

3121 General medicine, internal medicine and other clinical medicine

Access to Document

10.3389/fimmu.2023.1060540

fimmu-14-1060540 (2)Final published version, 12.2 MBLicence: CC BY

Cite this

Clubb, J. H. A., Kudling, T. V., Girych, M., Haybout, L., Pakola, S., Hamdan, F., Cervera-Carrascon, V., Hemmes, A., Grönberg-Vähä-Koskela, S., Santos, J. M., Quixabeira, D. C. A., Basnet, S., Heiniö, C., Arias, V., Jirovec, E., Kaptan, S., Havunen, R., Sorsa, S., Erikat, A., ... Hemminki, A. (2023). Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting. Frontiers in Immunology, 14, [1060540]. https://doi.org/10.3389/fimmu.2023.1060540

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title = "Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting",

keywords = "Pdac, Syrian hamster, Adenovirus, Artificial intelligence, Immune checkpoint inhibitor, Immunotherapy, Molecular simulations, Oncolytic virus, 3121 General medicine, internal medicine and other clinical medicine",

author = "Clubb, {James H. A.} and Kudling, {Tatiana V.} and Mykhailo Girych and Lyna Haybout and Santeri Pakola and Firas Hamdan and Victor Cervera-Carrascon and Annabrita Hemmes and Susanna Gr{\"o}nberg-V{\"a}h{\"a}-Koskela and Santos, {Joao Manuel} and Quixabeira, {Dafne C. A.} and Saru Basnet and Camilla Heini{\"o} and Victor Arias and Elise Jirovec and Shreyas Kaptan and Riikka Havunen and Suvi Sorsa and Abdullah Erikat and Joel Schwartz and Marjukka Anttila and Katri Aro and Tapani Viitala and Ilpo Vattulainen and Vincenzo Cerullo and Anna Kanerva and Akseli Hemminki",

year = "2023",

month = feb,

day = "3",

doi = "10.3389/fimmu.2023.1060540",

language = "English",

volume = "14",

journal = "Frontiers in Immunology",

issn = "1664-3224",

publisher = "Frontiers Media",

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Clubb, JHA, Kudling, TV , Girych, M, Haybout, L, Pakola, S , Hamdan, F, Cervera-Carrascon, V, Hemmes, A, Grönberg-Vähä-Koskela, S, Santos, JM, Quixabeira, DCA, Basnet, S, Heiniö, C, Arias, V , Jirovec, E, Kaptan, S, Havunen, R, Sorsa, S, Erikat, A, Schwartz, J, Anttila, M, Aro, K , Viitala, T , Vattulainen, I , Cerullo, V , Kanerva, A & Hemminki, A 2023, 'Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting', Frontiers in Immunology, vol. 14, 1060540. https://doi.org/10.3389/fimmu.2023.1060540

Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting. / Clubb, James H. A.; Kudling, Tatiana V.; Girych, Mykhailo et al.

In: Frontiers in Immunology, Vol. 14, 1060540, 03.02.2023.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting

AU - Clubb, James H. A.

AU - Kudling, Tatiana V.

AU - Girych, Mykhailo

AU - Haybout, Lyna

AU - Pakola, Santeri

AU - Hamdan, Firas

AU - Cervera-Carrascon, Victor

AU - Hemmes, Annabrita

AU - Grönberg-Vähä-Koskela, Susanna

AU - Santos, Joao Manuel

AU - Quixabeira, Dafne C. A.

AU - Basnet, Saru

AU - Heiniö, Camilla

AU - Arias, Victor

AU - Jirovec, Elise

AU - Kaptan, Shreyas

AU - Havunen, Riikka

AU - Sorsa, Suvi

AU - Erikat, Abdullah

AU - Schwartz, Joel

AU - Anttila, Marjukka

AU - Aro, Katri

AU - Viitala, Tapani

AU - Vattulainen, Ilpo

AU - Cerullo, Vincenzo

AU - Kanerva, Anna

AU - Hemminki, Akseli

PY - 2023/2/3

Y1 - 2023/2/3

KW - Pdac

KW - Syrian hamster

KW - Adenovirus

KW - Artificial intelligence

KW - Immune checkpoint inhibitor

KW - Immunotherapy

KW - Molecular simulations

KW - Oncolytic virus

KW - 3121 General medicine, internal medicine and other clinical medicine

U2 - 10.3389/fimmu.2023.1060540

DO - 10.3389/fimmu.2023.1060540

M3 - Article

C2 - 36817448

VL - 14

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 1060540

ER -