Diatoms: a natural source of nanostructured silica for drug delivery

Monica Terracciano, Ilaria Rea, Luca De Stefano, Helder Almeida Santos

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Abstract

Diatoms, single-celled photosynthetic algae, are great source of intricate natural porous silica materials. The whole diatom cell is confined in 3-dimensional ordered nanopatterned silica cell wall, called frustule. The unique features of diatom frustules, such as great specific surface area, biocompatibility and non-toxicity due to the silica composition, easily modifiable surface, high mechanical resistance, thermal stability, make them suitable for drug delivery applications. Moreover, the easy cultivation of diatoms in artificial environment, the huge availability of diatom frustules as fossil material (diatomite) in several areas of the world and the peculiar propertiess, further confirm the advantage of using diatoms porous silica as alternative to synthetic materials for biomedical applications. In this chapter, the possible use of diatoms as microfrustules or reduced to nanoparticlesas drug vectors are described. The processing of diatom frustules for drug delivery carriers preparation, biocompatibility tests, surface chemical modifications, cellular uptake and capability to transport therapeutic molecules inside cells are also discussed.
Original languageEnglish
Title of host publicationDiatom Nanotechnology Progress and Emerging Applications
EditorsDusan Losic
Number of pages18
PublisherThe Royal Society of Chemistry
Publication date2018
Pages201–218
ISBN (Print)978-1-78262-932-0
ISBN (Electronic)978-1-78801-016-0, 978-1-78801-248-5
DOIs
Publication statusPublished - 2018
MoE publication typeA3 Book chapter

Fields of Science

  • 317 Pharmacy

Cite this

Terracciano, M., Rea, I., De Stefano, L., & Almeida Santos, H. (2018). Diatoms: a natural source of nanostructured silica for drug delivery. In D. Losic (Ed.), Diatom Nanotechnology Progress and Emerging Applications (pp. 201–218). The Royal Society of Chemistry. https://doi.org/10.1039/9781788010160-00201
Terracciano, Monica ; Rea, Ilaria ; De Stefano, Luca ; Almeida Santos, Helder. / Diatoms: a natural source of nanostructured silica for drug delivery. Diatom Nanotechnology Progress and Emerging Applications. editor / Dusan Losic. The Royal Society of Chemistry, 2018. pp. 201–218
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Terracciano, M, Rea, I, De Stefano, L & Almeida Santos, H 2018, Diatoms: a natural source of nanostructured silica for drug delivery. in D Losic (ed.), Diatom Nanotechnology Progress and Emerging Applications. The Royal Society of Chemistry, pp. 201–218. https://doi.org/10.1039/9781788010160-00201

Diatoms: a natural source of nanostructured silica for drug delivery. / Terracciano, Monica ; Rea, Ilaria ; De Stefano, Luca ; Almeida Santos, Helder.

Diatom Nanotechnology Progress and Emerging Applications. ed. / Dusan Losic. The Royal Society of Chemistry, 2018. p. 201–218.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

TY - CHAP

T1 - Diatoms: a natural source of nanostructured silica for drug delivery

AU - Terracciano, Monica

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AU - De Stefano, Luca

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PY - 2018

Y1 - 2018

N2 - Diatoms, single-celled photosynthetic algae, are great source of intricate natural porous silica materials. The whole diatom cell is confined in 3-dimensional ordered nanopatterned silica cell wall, called frustule. The unique features of diatom frustules, such as great specific surface area, biocompatibility and non-toxicity due to the silica composition, easily modifiable surface, high mechanical resistance, thermal stability, make them suitable for drug delivery applications. Moreover, the easy cultivation of diatoms in artificial environment, the huge availability of diatom frustules as fossil material (diatomite) in several areas of the world and the peculiar propertiess, further confirm the advantage of using diatoms porous silica as alternative to synthetic materials for biomedical applications. In this chapter, the possible use of diatoms as microfrustules or reduced to nanoparticlesas drug vectors are described. The processing of diatom frustules for drug delivery carriers preparation, biocompatibility tests, surface chemical modifications, cellular uptake and capability to transport therapeutic molecules inside cells are also discussed.

AB - Diatoms, single-celled photosynthetic algae, are great source of intricate natural porous silica materials. The whole diatom cell is confined in 3-dimensional ordered nanopatterned silica cell wall, called frustule. The unique features of diatom frustules, such as great specific surface area, biocompatibility and non-toxicity due to the silica composition, easily modifiable surface, high mechanical resistance, thermal stability, make them suitable for drug delivery applications. Moreover, the easy cultivation of diatoms in artificial environment, the huge availability of diatom frustules as fossil material (diatomite) in several areas of the world and the peculiar propertiess, further confirm the advantage of using diatoms porous silica as alternative to synthetic materials for biomedical applications. In this chapter, the possible use of diatoms as microfrustules or reduced to nanoparticlesas drug vectors are described. The processing of diatom frustules for drug delivery carriers preparation, biocompatibility tests, surface chemical modifications, cellular uptake and capability to transport therapeutic molecules inside cells are also discussed.

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BT - Diatom Nanotechnology Progress and Emerging Applications

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Terracciano M, Rea I, De Stefano L, Almeida Santos H. Diatoms: a natural source of nanostructured silica for drug delivery. In Losic D, editor, Diatom Nanotechnology Progress and Emerging Applications. The Royal Society of Chemistry. 2018. p. 201–218 https://doi.org/10.1039/9781788010160-00201